Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility

Autor: Ondrej Mihola, Vladimir Landa, Florencia Pratto, Kevin Brick, Tatyana Kobets, Fitore Kusari, Srdjan Gasic, Fatima Smagulova, Corinne Grey, Petr Flachs, Vaclav Gergelits, Karel Tresnak, Jan Silhavy, Petr Mlejnek, R. Daniel Camerini-Otero, Michal Pravenec, Galina V. Petukhova, Zdenek Trachtulec

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)

Abstract Background Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of histone 3 (H3K4me3 and H3K36me3). Mouse and human PRDM9 proteins catal

Externí odkaz: https://doaj.org/article/03a0d82fd99840bf996152ad7bf19c03

Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots.

Autor: Christopher L Baker, Pavlina Petkova, Michael Walker, Petr Flachs, Ondrej Mihola, Zdenek Trachtulec, Petko M Petkov, Kenneth Paigen

Publikováno v: PLoS Genetics, Vol 11, Iss 9, p e1005512 (2015)

Genetic recombination during meiosis functions to increase genetic diversity, promotes elimination of deleterious alleles, and helps assure proper segregation of chromatids. Mammalian recombination events are concentrated at specialized sites, termed

Externí odkaz: https://doaj.org/article/9d4cabb3f38d426994cbdbc5144ef1d2

Copy-number variation introduced by long transgenes compromises mouse male fertility independently of pachytene checkpoints

Autor: Klara Krivankova, Tatyana Kobets, Srdjan Gasic, Zdenek Trachtulec, Ondrej Mihola, Eliska Linhartova, John C. Schimenti

Publikováno v: Chromosoma. 129:69-82

Long transgenes are often used in mammalian genetics, e.g., to rescue mutations in large genes. In the course of experiments addressing the genetic basis of hybrid sterility caused by meiotic defects in mice bearing different alleles of Prdm9, we dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0f636a07f2a85b5c8f26ea0dfc7477
https://doi.org/10.1007/s00412-019-00730-8

Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility

Autor: Vladimír Landa, Fatima Smagulova, Florencia Pratto, Ondrej Mihola, Michal Pravenec, Srdjan Gasic, R. Daniel Camerini-Otero, Petr Flachs, Corinne Grey, Fitore Kusari, Karel Tresnak, Vaclav Gergelits, Galina V. Petukhova, Petr Mlejnek, Zdenek Trachtulec, Tatyana Kobets, Kevin Brick, Jan Silhavy

Publikováno v: BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
BMC Biology, 2021, 19 (1), pp.86. ⟨10.1186/s12915-021-01017-0⟩
BMC Biology, BioMed Central, 2021, 19 (1), pp.86. ⟨10.1186/s12915-021-01017-0⟩

BackgroundVertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of histone 3 (H3K4me3 and H3K36me3). Mouse and human PRDM9 proteins catalyze H3K4me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970f33764fc5f3a889d99e6f80d17876
https://pubmed.ncbi.nlm.nih.gov/33910563

Fine Haplotype Structure of a Chromosome 17 Region in the Laboratory and Wild Mouse

Autor: Jiri Forejt, Zdenek Trachtulec, Sona Gregorova, Ondrej Mihola, Vladana Fotopulosova, Čestmír Vlček

Publikováno v: Genetics. 178:1777-1784

Extensive linkage disequilibrium among classical laboratory strains represents an obstacle in the high-resolution haplotype mapping of mouse quantitative trait loci (QTL). To determine the potential of wild-derived mouse strains for fine QTL mapping,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe11ed4962f80a43d3f605aa725f001b
https://doi.org/10.1534/genetics.107.082404