Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Ondrej Kuda"'
Autor:
Barbora Judita Kasperova, Milos Mraz, Petr Svoboda, Daniel Hlavacek, Helena Kratochvilova, Istvan Modos, Nikola Vrzackova, Peter Ivak, Petra Janovska, Tatyana Kobets, Jakub Mahrik, Martin Riecan, Lenka Steiner Mrazova, Viktor Stranecky, Ivan Netuka, Tomas Cajka, Ondrej Kuda, Vojtech Melenovsky, Sona Stemberkova Hubackova, Martin Haluzik
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are glucose-lowering agents used for the treatment of type 2 diabetes mellitus, which also improve heart failure and decrease the risk of cardiovascular complications. Epicardial
Externí odkaz:
https://doaj.org/article/f5b7b9bcaae44ad086f3948fb34547db
Autor:
Tomas Cajka, Jiri Hricko, Stanislava Rakusanova, Kristyna Brejchova, Michaela Novakova, Lucie Rudl Kulhava, Veronika Hola, Michaela Paucova, Oliver Fiehn, Ondrej Kuda
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2899 (2024)
Liquid chromatography with mass spectrometry (LC-MS)-based metabolomics detects thousands of molecular features (retention time–m/z pairs) in biological samples per analysis, yet the metabolite annotation rate remains low, with 90% of signals class
Externí odkaz:
https://doaj.org/article/327021b970794780b040224647bf32e0
Autor:
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Oliver Fiehn, Ondrej Kuda
Publikováno v:
Metabolites, Vol 13, Iss 9, p 966 (2023)
Liquid chromatography–mass spectrometry (LC-MS) is the key technique for analyzing complex lipids in biological samples. Various LC-MS modes are used for lipid separation, including different stationary phases, mobile-phase solvents, and modifiers.
Externí odkaz:
https://doaj.org/article/0912489f1bda48be88109c6c1777e162
Autor:
Miriam Jacome-Sosa, Zhi-Feng Miao, Vivek S. Peche, Edward F. Morris, Ramkumar Narendran, Kathryn M. Pietka, Dmitri Samovski, Hei-Yong G. Lo, Terri Pietka, Andrea Varro, Latisha Love-Gregory, James R. Goldenring, Ondrej Kuda, Eric R. Gamazon, Jason C. Mills, Nada A. Abumrad
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Jacome-Sosa et al. examine gastric function of CD36, reporting that CD36 knockout mice have altered gland organization and exhibit more fibronectin and inflammatory signaling. The authors find mucosal repair is abrogated due to defective epithelial c
Externí odkaz:
https://doaj.org/article/f9ec101e1f814b5fab8d34541185e8f0
Autor:
Vincenza Cifarelli, Ondrej Kuda, Kui Yang, Xinping Liu, Richard W. Gross, Terri A. Pietka, Gyu Seong Heo, Deborah Sultan, Hannah Luehmann, Josie Lesser, Morgan Ross, Ira J. Goldberg, Robert J. Gropler, Yongjian Liu, Nada A. Abumrad
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
CD36 mediates the uptake of long-chain fatty acids (FAs), a major energy substrate for the myocardium. Under excessive FA supply, CD36 can cause cardiac lipid accumulation and inflammation while its deletion reduces heart FA uptake and lipid content
Externí odkaz:
https://doaj.org/article/bfbdb0257f3749e7ad0b6d0009d78f34
Autor:
Josef Oeckl, Petra Janovska, Katerina Adamcova, Kristina Bardova, Sarah Brunner, Sebastian Dieckmann, Josef Ecker, Tobias Fromme, Jiri Funda, Thomas Gantert, Piero Giansanti, Maria Soledad Hidrobo, Ondrej Kuda, Bernhard Kuster, Yongguo Li, Radek Pohl, Sabine Schmitt, Sabine Schweizer, Hans Zischka, Petr Zouhar, Jan Kopecky, Martin Klingenspor
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101499- (2022)
Objective: Classical ATP-independent non-shivering thermogenesis enabled by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in the cold. It has long been suspected that futile ATP-consuming subs
Externí odkaz:
https://doaj.org/article/02a486b5a3c54c2cbc43e4898dd4d342
Autor:
Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Ondrej Kuda, Oliver Fiehn, Tomas Cajka
Publikováno v:
Antioxidants, Vol 12, Iss 5, p 986 (2023)
Thermal reactions can significantly alter the metabolomic and lipidomic content of biofluids and tissues during storage. In this study, we investigated the stability of polar metabolites and complex lipids in dry human serum and mouse liver extracts
Externí odkaz:
https://doaj.org/article/36125e8393484a0fbe1e4ababa388780
Autor:
Helena L Fisk, Caroline E Childs, Elizabeth A Miles, Robert Ayres, Paul S Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A Lillycrop, Philip C Calder
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103909- (2022)
Summary: Background: Obesity is associated with enhanced inflammation. However, investigation in human subcutaneous white adipose tissue (scWAT) is limited and the mechanisms by which inflammation occurs have not been well elucidated. Marine long cha
Externí odkaz:
https://doaj.org/article/eeea09af131447a1a9db2d2f8b6713f8
Autor:
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Ondrej Kuda
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1987 (2023)
Liquid chromatography-mass spectrometry (LC-MS) is the method of choice for the untargeted profiling of biological samples. A multiplatform LC-MS-based approach is needed to screen polar metabolites and lipids comprehensively. Different mobile phase
Externí odkaz:
https://doaj.org/article/bbc52854e5e4472db75394540c0a51ea
Autor:
Viktor Bugajev, Tomas Paulenda, Pavol Utekal, Michal Mrkacek, Ivana Halova, Ladislav Kuchar, Ondrej Kuda, Petra Vavrova, Björn Schuster, Sergio Fuentes-Liso, Lucie Potuckova, Daniel Smrz, Sara Cernohouzova, Lubica Draberova, Monika Bambouskova, Petr Draber
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100121- (2021)
Leukotrienes (LTs) and sphingolipids are critical lipid mediators participating in numerous cellular signal transduction events and developing various disorders, such as bronchial hyperactivity leading to asthma. Enzymatic reactions initiating produc
Externí odkaz:
https://doaj.org/article/058a630f0eee440cb9b82b31fbd5f3ff