Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ondrej Hrabina"'
Publikováno v:
Chemistry – A European Journal. 26:16554-16562
Bulges are essential structural elements in nucleic acids. The detection and targeting of bulged DNA sequences are highly important. Small molecules capable of targeting DNA bulges have attracted considerable attention because they cannot only be use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d00e59cc25321491b033cc2d267bbc23
https://doi.org/10.1002/chem.202004060
https://doi.org/10.1002/chem.202004060
Autor:
Jitka Pracharova, Ondrej Hrabina, Hana Kostrhunova, Jaroslav Malina, Viktor Brabec, Peter Scott, Vojtech Novohradsky, Daniel H. Simpson, Nicola J. Rogers
Publikováno v:
Inorganic Chemistry. 59:3304-3311
The water-compatible optically pure metallohelices made by self-assembly of simple nonpeptidic organic components around Fe(II) ions are now recognized as a distinct subclass of helicates that exhibit similar architecture to some natural cationic ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86387045e1c63fca0eb7b11f1c33c1b
https://doi.org/10.1021/acs.inorgchem.0c00092
https://doi.org/10.1021/acs.inorgchem.0c00092
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 26(69)
Bulges are essential structural elements in nucleic acids. The detection and targeting of bulged DNA sequences are highly important. Small molecules capable of targeting DNA bulges have attracted considerable attention because they cannot only be use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c41538085f96849519fb6a49be0446e9
https://pubmed.ncbi.nlm.nih.gov/33026666
https://pubmed.ncbi.nlm.nih.gov/33026666
Publikováno v:
Coordination Chemistry Reviews. 351:2-31
Despite the widespread use of antineoplastic platinum drugs, a number of accompanying disadvantages exist. In connection with attempts to circumvent these problems new platinum compounds have been prepared and mechanisms underlying their biological a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b504d8afb9e23a8b3a593c622d3abd5a
https://doi.org/10.1016/j.ccr.2017.04.013
https://doi.org/10.1016/j.ccr.2017.04.013
Autor:
Viktor Brabec, David I. Roper, Jaroslav Malina, Andrew D. Millard, Peter Scott, Nicola J. Rogers, Gemma L. Kay, Nicholas R. Waterfield, David J. Fox, Alexia Hapeshi, Ondrej Hrabina, Guy J. Clarkson, Hualong Song, John Moat, Andrew K. King, Daniel H. Simpson
Publikováno v:
Chemical Science
Iron-based self-assembled optically pure compounds mimic the mechanisms of small peptides, according to biophysical, genomic, transcriptomic and other analyses.
A range of new water-compatible optically pure metallohelices – made by self-assem
A range of new water-compatible optically pure metallohelices – made by self-assem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5411c9249665344aeb76da62abefce
https://pubmed.ncbi.nlm.nih.gov/32015803
https://pubmed.ncbi.nlm.nih.gov/32015803
Autor:
Ondrej Hrabina, Zijian Guo, Vojtech Novohradsky, Viktor Brabec, Jana Kasparkova, Tereza Suchankova
Publikováno v:
Metallomics. 9:494-500
The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH3)2Cl]2(4,4′-methylenedianiline)}2+ (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3′–3′ direction. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35ae3cbb9e31896f34a361063b840ba
https://doi.org/10.1039/c7mt00052a
https://doi.org/10.1039/c7mt00052a
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5012 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 20
International Journal of Molecular Sciences
Volume 20
Issue 20
Oxidative stress in cells can lead to the accumulation of reactive oxygen species and oxidation of DNA precursors. Oxidized nucleotides such as 2&rsquo
deoxyribo-5-hydroxyuridin (HdU) and 2&rsquo
deoxyribo-5-hydroxymethyluridin (HMdU) can b
deoxyribo-5-hydroxyuridin (HdU) and 2&rsquo
deoxyribo-5-hydroxymethyluridin (HMdU) can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f1f323728e777617c042cdacfaebc8
https://doi.org/10.3390/ijms20205012
https://doi.org/10.3390/ijms20205012
Autor:
Viktor Brabec, Tiziano Marzo, Mirko Severi, Alessandro Lunghi, Jana Kasparkova, Chiara Gabbiani, Luigi Messori, Annarosa Arcangeli, Adoración G. Quiroga, Serena Pillozzi, Gianluca Bartoli, Ondrej Hrabina, Federico Totti
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
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The investigation of cis-PtI2(NH3)2, the diiodido analogue of cisplatin (cisPtI2 hereafter), has been unjustly overlooked so far mainly because of old claims of pharmacological inactivity. Some recent - but still fragmentary - findings prompted us to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9c463176055e79384043c10f3e6bb7
https://pubmed.ncbi.nlm.nih.gov/26226326
https://pubmed.ncbi.nlm.nih.gov/26226326