Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Ondrej, Soukup"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S426-S427 (2023)
Externí odkaz:
https://doaj.org/article/f32fd60a04004897ba8b70b1e52c5744
Autor:
Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Fabova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2605-2620 (2022)
Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti-monoamine oxidase activities. Propargyltacrine 23 (IC50 = 21 nM) was the mo
Externí odkaz:
https://doaj.org/article/1b4b604d4ed2463eadfec515d42a5564
Autor:
Chrysostomi Christina Tsianou, Jaroslav Kvetina, Vera Radochova, Darina Kohoutova, Stanislav Rejchrt, Martin Valis, Jana Zdarova Karasova, Ilja Tacheci, Veronika Knoblochova, Ondrej Soukup, Jan Bures
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286386 (2023)
BackgroundRivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer's disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clin
Externí odkaz:
https://doaj.org/article/18153c20d6b24bac911c694b74ac254a
Autor:
Jana Janockova, Jan Korabecny, Jana Plsikova, Katerina Babkova, Eva Konkolova, Dana Kucerova, Jana Vargova, Jan Koval, Rastislav Jendzelovsky, Peter Fedorocko, Jana Kasparkova, Viktor Brabec, Jan Rosocha, Ondrej Soukup, Slavka Hamulakova, Kamil Kuca, Maria Kozurkova
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 877-897 (2019)
A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea heterodimers 18–22, and to measure interference with type I and II to
Externí odkaz:
https://doaj.org/article/6487d4fed0064893867020e3dda083eb
Autor:
Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M. Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 163-170 (2019)
In view of the multifactorial nature of Alzheimer’s disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer’s disease therapy. The new MTSM KojoTacrines (KTs
Externí odkaz:
https://doaj.org/article/e3c0e08c463645d08a8cc7dd58a4bda9
Autor:
Ondrej Soukup, Jan Korabecny
Publikováno v:
Toxics, Vol 10, Iss 8, p 444 (2022)
The scope of this Special Issue is to pay attention to various aspects of toxicology specifically focused on the chemical and biological threats, which may accidentally, or on purpose, endanger human health [...]
Externí odkaz:
https://doaj.org/article/d60a4afa040a4b63ac733eee4805680a
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Igor V. Serkov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Jan Korabecny, Ondrej Soukup, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 27, Iss 3, p 1060 (2022)
Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-N-acyl-alkylene (3) and bis-N-thiourea-
Externí odkaz:
https://doaj.org/article/90ae90fd4e9f4057a738309e4978db2b
Autor:
Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho
Publikováno v:
BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes. Methods To det
Externí odkaz:
https://doaj.org/article/ba8425cd990247f4bd02fb26adefa794
Autor:
Eva Mezeiova, Katarina Spilovska, Eugenie Nepovimova, Lukas Gorecki, Ondrej Soukup, Rafael Dolezal, David Malinak, Jana Janockova, Daniel Jun, Kamil Kuca, Jan Korabecny
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 583-606 (2018)
Alzheimer’s disease is debilitating neurodegenerative disorder in the elderly. Current therapy relies on administration of acetylcholinesterase inhibitors (AChEIs) -donepezil, rivastigmine, galantamine, and N-methyl-d-aspartate receptor antagonist
Externí odkaz:
https://doaj.org/article/f4d7abc278ba4229b488013ba972aa08
Autor:
Annachiara Gandini, Ana Elisa Gonçalves, Silvia Strocchi, Claudia Albertini, Jana Janočková, Anna Tramarin, Daniela Grifoni, Eleonora Poeta, Ondrej Soukup, Diego Muñoz-Torrero, Barbara Monti, Raimon Sabaté, Manuela Bartolini, Giuseppe Legname, Maria Laura Bolognesi
Publikováno v:
ACS Chemical Neuroscience. 13:3314-3329
Alzheimer's disease (AD), the most common type of dementia, currently represents an extremely challenging and unmet medical need worldwide. Amyloid-β (Aβ) and Tau proteins are prototypical AD hallmarks, as well as validated drug targets. Accumulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120f6def0a91bcbe6be2b2a3c0aece78
https://doi.org/10.1021/acschemneuro.2c00357
https://doi.org/10.1021/acschemneuro.2c00357