Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ondřej Smolík"'
Autor:
Martin Knytl, Ondřej Smolík, Svatava Kubíčková, Tereza Tlapáková, Ben J Evans, Vladimír Krylov
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177087 (2017)
Whole genome duplication (WGD) generates new species and genomic redundancy. In African clawed frogs of the genus Xenopus, this phenomenon has been especially important in that (i) all but one extant species are polyploid and (ii) whole genome sequen
Externí odkaz:
https://doaj.org/article/855a55495a954077b46d83c5bb41e974
Autor:
Gabriela Pavlinkova, Ondrej Smolik
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Transcription factors belonging to the basic helix-loop-helix (bHLH) family are key regulators of cell fate specification and differentiation during development. Their dysregulation is implicated not only in developmental abnormalities but also in va
Externí odkaz:
https://doaj.org/article/71739581bd5c41e0bfdcf6b5939e0738
Autor:
Romana Bohuslavova, Valeria Fabriciova, Ondrej Smolik, Laura Lebrón-Mora, Pavel Abaffy, Sarka Benesova, Daniel Zucha, Lukas Valihrach, Zuzana Berkova, Frantisek Saudek, Gabriela Pavlinkova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic β cells. Disruption of Neurod1 during pancreatic development causes severe neonatal diabetes; however, the exact role of NEUROD1 in the differentiation p
Externí odkaz:
https://doaj.org/article/c45597d335e84dfdbb6ee6266b7d9794
Autor:
Romana Bohuslavova, Valeria Fabriciova, Laura Lebrón-Mora, Jessica Malfatti, Ondrej Smolik, Lukas Valihrach, Sarka Benesova, Daniel Zucha, Zuzana Berkova, Frantisek Saudek, Sylvia M Evans, Gabriela Pavlinkova
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-24 (2023)
Abstract Background Glucose homeostasis is dependent on functional pancreatic α and ß cells. The mechanisms underlying the generation and maturation of these endocrine cells remain unclear. Results We unravel the molecular mode of action of ISL1 in
Externí odkaz:
https://doaj.org/article/b82aec0be9b34ada9dbcc1271383d8de
Autor:
Ravindra Naraine, Pavel Abaffy, Monika Sidova, Silvie Tomankova, Kseniia Pocherniaieva, Ondrej Smolik, Mikael Kubista, Martin Psenicka, Radek Sindelka
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1173-1181 (2020)
The merit of RNASeq data relies heavily on correct normalization. However, most methods assume that the majority of transcripts show no differential expression between conditions. This assumption may not always be correct, especially when one conditi
Externí odkaz:
https://doaj.org/article/c82fb33bbbb742fda12a564e7edc6dcb
Autor:
Romana Bohuslavova, Ondrej Smolik, Jessica Malfatti, Zuzana Berkova, Zaneta Novakova, Frantisek Saudek, Gabriela Pavlinkova
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6713 (2021)
Diabetes is a metabolic disease that involves the death or dysfunction of the insulin-secreting β cells in the pancreas. Consequently, most diabetes research is aimed at understanding the molecular and cellular bases of pancreatic development, islet
Externí odkaz:
https://doaj.org/article/3e52ef94d2f446b481ce9baebcf90faa