Zobrazeno 1 - 10 of 69 pro vyhledávání: '"Oncolytic and Local Immunotherapy"'
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CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model
Autor: Ruikun Wang, Jingru Chen, Wei Wang, Zhuoqian Zhao, Haoran Wang, Shiyu Liu, Fan Li, Yajuan Wan, Jie Yin, Rui Wang, Yuanke Li, Cuizhu Zhang, Hongkai Zhang, Youjia Cao
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Journal for Immunotherapy of Cancer
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide. Despite the promising outcome of immune checkpoint inhibitors and agonist antibody therapies in different malignancies, PDAC exhibits high resistance du
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac520690c09f182c64832d87290906cc
https://jitc.bmj.com/content/10/1/e003809.full
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3
Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8
Autor: Monika, Semmrich, Jean-Baptiste, Marchand, Laetitia, Fend, Matilda, Rehn, Christelle, Remy, Petra, Holmkvist, Nathalie, Silvestre, Carolin, Svensson, Patricia, Kleinpeter, Jules, Deforges, Fred, Junghus, Kirstie L, Cleary, Mimoza, Bodén, Linda, Mårtensson, Johann, Foloppe, Ingrid, Teige, Eric, Quéméneur, Björn, Frendéus
Publikováno v: Journal for Immunotherapy of Cancer
Background Immune checkpoint blockade (ICB) is a clinically proven concept to treat cancer. Still, a majority of patients with cancer including those with poorly immune infiltrated ‘cold’ tumors are resistant to currently available ICB therapies.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09bd94ed6325ee24b261cd0627e28c52
https://pubmed.ncbi.nlm.nih.gov/35058324
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4
An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade
Autor: Shuguang Zuo, Min Wei, Tiancheng Xu, Lingkai Kong, Bohao He, Shiqun Wang, Shibing Wang, Junhua Wu, Jie Dong, Jiwu Wei
Publikováno v: Journal for Immunotherapy of Cancer
BackgroundIn addition to directly lysing tumors, oncolytic viruses also induce antitumor immunity by recruiting and activating immune cells in the local tumor microenvironment. However, the activation of the immune cells induced by oncolytic viruses
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae50ebe75b2f4b2018620ee0511c4d1
http://europepmc.org/articles/PMC8705214
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5
Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models
Autor: Marilin S Koch, Mykola Zdioruk, Michal O Nowicki, Alec M Griffith, Estuardo Aguilar, Laura K Aguilar, Brian W Guzik, Francesca Barone, Paul P Tak, Ghazaleh Tabatabai, James A Lederer, E Antonio Chiocca, Sean Lawler
Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
BackgroundIntratumoral viral oncolytic immunotherapy is a promising new approach for the treatment of a variety of solid cancers. CAN-2409 is a replication-deficient adenovirus that delivers herpes simplex virus thymidine kinase to cancer cells, resu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b8be09b80beec58beda1af9d511f57
https://pubmed.ncbi.nlm.nih.gov/35017150
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6
Leveraging immune memory against measles virus as an antitumor strategy in a preclinical model of aggressive squamous cell carcinoma
Autor: Richard Greil, Lisa Trattner, Nadja Zaborsky, Sophie Kitzmueller, Dirk Strunk, Gabriele Brachtl, Markus Steiner, Angelika Stoecklinger, Melanie Kienzl, Iris K. Gratz, Christian Reinsch, B. Tockner, Patrick Kreideweiss, Josefina Piñón Hofbauer, Johann W. Bauer, Anna Kaufmann, Steffen Panzner, Christina Guttmann-Gruber, V. Leb-Reichl
Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Viral antigens are among the strongest elicitors of immune responses. A significant proportion of the human population already carries pre-existing immunity against several childhood viruses, which could potentially be leveraged to fight cancer. We s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6feaa7bf6dddcb241dfcabe0396c21ac
http://europepmc.org/articles/PMC8532558
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7
Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments
Autor: Meghana V. Bapardekar, Gautam N Shenoy, Leonard D. Shultz, Gerald P. Linette, Koon Y. Pak, Sathy V. Balu-Iyer, Richard B. Bankert, Maulasri Bhatta, Hans Minderman, Jenni L Loyall, Brian D. Gray, Alexis Conway, Beatriz M. Carreno, Kunle Odunsi, Raymond J. Kelleher
Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
BackgroundThe human tumor microenvironment (TME) is a complex and dynamic milieu of diverse acellular and cellular components, creating an immunosuppressive environment, which contributes to tumor progression. We have previously shown that phosphatid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f6494627bca4c177e390be57e894cd
http://europepmc.org/articles/PMC8488709
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8
Synergy between
Autor: Yu-Chao, Zhu, Hany M, Elsheikha, Jian-Hua, Wang, Shuai, Fang, Jun-Jun, He, Xing-Quan, Zhu, Jia, Chen
Publikováno v: Journal for Immunotherapy of Cancer
Background In this study, we hypothesize that the ability of the protozoan Toxoplasma gondii to modulate immune response within the tumor might improve the therapeutic effect of immune checkpoint blockade. We examined the synergetic therapeutic activ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ad309228639c97c29dc2cb2daec5047
https://pubmed.ncbi.nlm.nih.gov/34725213
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9
Correction: Real-life use of talimogene laherparepvec (T-VEC) in melanoma patients in centers in Austria, Switzerland and Germany
Publikováno v: Journal for Immunotherapy of Cancer
Background Talimogene laherparepvec (T-VEC) is a licensed therapy for use in melanoma patients of stage IIIB-IVM1a with injectable, unresectable metastatic lesions in Europe. Approval was based on the Oncovex Pivotal Trial in Melanoma study, which al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4d34473195497216581ddce3191c1651
http://europepmc.org/articles/PMC8515457
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10
VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects
Autor: Joan B. Gornals, Manuel Hidalgo, Sofia Perea, Maria Victoria Maliandi, Susana Prados, Alba Rodriguez-Garcia, Ramon Alemany, Rafael Álvarez, Mercedes Pérez-Carreras, Mireia M. Ginestà, Ana Mato-Berciano, Carmen Blasco, Rocio Garcia-Carbonero, Sara Morgado, Berta Laquente, M Carmen Riesco, Manel Cascallo, Marta Gimenez-Alejandre, Rafael Moreno, Emma Blasi, Gabriel Capellá, Ramon Salazar, Miriam Bazan-Peregrino
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)
Journal for Immunotherapy of Cancer
BackgroundPancreatic ductal adenocarcinoma (PDAC) is characterized by dense desmoplastic stroma that limits the delivery of anticancer agents. VCN-01 is an oncolytic adenovirus designed to replicate in cancer cells with a dysfunctional RB1 pathway an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716b45869decdb02201ba51c64063fd1
https://pubmed.ncbi.nlm.nih.gov/35149591
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