Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Oncology/Sarcomas"'
Autor:
Janine Senz, Malachi Griffith, Sohrab P. Shah, Alireza Heravi Moussavi, David G. Huntsman, Torsten O. Nielsen, Marina Pacheco, Gavin Ha, Martin Hirst, Marco A. Marra, Nataliya Melnyk, Mark G. F. Sun, S. Cenk Sahinalp, Ryan Giuliany, Fereydoun Hormozdiari, Abdalnasser Zayed, Andrew McPherson
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 5, p e1001138 (2011)
PLoS Computational Biology
PLoS Computational Biology
Gene fusions created by somatic genomic rearrangements are known to play an important role in the onset and development of some cancers, such as lymphomas and sarcomas. RNA-Seq (whole transcriptome shotgun sequencing) is proving to be a useful tool f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54bfa6c8a8abd670bc8ddc4900713674
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21625565/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21625565/?tool=EBI
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14648 (2011)
PLoS ONE
PLoS ONE
Background BMI-1 is a member of the polycomb group of genes (PcGs), and it has been implicated in the development and progression of several malignancies, but its role in osteosarcoma remains to be elucidated. Methodology/Principal Findings In the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb4b5f11e01b5ae5066eb132bf7f364
http://europepmc.org/articles/PMC3032734?pdf=render
http://europepmc.org/articles/PMC3032734?pdf=render
Autor:
Jolanta Lissowska, Jun S. Wei, Jacob Calcei, Mark E. Sherman, Stephen M. Hewitt, Stephen J. Chanock, Hannah P. Yang, Jesus Gonzalez-Bosquet, Montserrat Garcia-Closas, Joseph Vockley, Javed Khan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e14522 (2011)
PLoS ONE, Vol 6, Iss 1, p e14522 (2011)
Identification of somatic mutations in cancer is a major goal for understanding and monitoring the events related to cancer initiation and progression. High resolution melting (HRM) curve analysis represents a fast, post-PCR high-throughput method fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebcec81ab9d0b1789d51d8f9cc019ea
http://europepmc.org/articles/PMC3022009
http://europepmc.org/articles/PMC3022009
Autor:
Roy M. Bremnes, Tom Donnem, Thomas Karsten Kilvær, Andrey Yurjevich Valkov, Lill-Tove Busund, Khalid Al-Shibli, Eivind Smeland, Sveinung Wergeland Sørbye
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e14611 (2011)
PLoS ONE, Vol 6, Iss 1, p e14611 (2011)
This paper is part of Sveinung Sørbye's doctoral thesis, available in Munin at http://hdl.handle.net/10037/5478 The purpose of this study was to clarify the prognostic significance of lymphocyte infiltration in soft tissue sarcomas (STS). Prognostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a88df6f858d22840d1d010a467fa73
https://hdl.handle.net/10037/3928
https://hdl.handle.net/10037/3928
Autor:
Yang Bi, Jikun Shen, Bai-Cheng He, Xiaoji Luo, Jian-Li Gao, Stephanie H. Kim, Xing Liu, Gaurav Luther, Tong-Chuan He, Linyuan Wang, Qing Luo, Qiong Shi, Farbod Rastegar, Ning Hu, Deana S. Shenaq, Enyi Huang, Yanhong Gao, Eric R. Wagner, Mi Li, Liang Chen, Wei Jiang, Jinyong Luo, Guo-Wei Zuo, Hue H. Luu, Ke Yang, Rex C. Haydon
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14182 (2010)
PLoS ONE
PLoS ONE
Background: Osteosarcoma is the most common primary malignancy of bone with poorly characterized molecular pathways important in its pathogenesis. Increasing evidence indicates that elevated lipid biosynthesis is a characteristic feature of cancer. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4548729247ec4c958e3d65d02e330dba
http://europepmc.org/articles/PMC2995727?pdf=render
http://europepmc.org/articles/PMC2995727?pdf=render
Autor:
Naheed Gul, Alison O'Neill, Jason T. Yustein, Varalakshmi Katuri, Ola Awad, Preeti Shah, Jeffrey A. Toretsky, Milton L. Brown, Yali Kong, David M. Loeb
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 11, p e13943 (2010)
PLoS ONE, Vol 5, Iss 11, p e13943 (2010)
Background: Cancer stem cells are a chemotherapy-resistant population capable of self-renewal and of regenerating the bulk tumor, thereby causing relapse and patient death. Ewing’s sarcoma, the second most common form of bone tumor in adolescents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e8ca19d748d160160452d55eb84a1b
http://europepmc.org/articles/PMC2978678
http://europepmc.org/articles/PMC2978678
Autor:
Elizabeth Fox, Yunkai Yu, Melissa Paoloni, Christina Mazcko, Timothy M. Fan, Daniel L. Gustafson, Liang Cao, Tanasa S. Osborne, William C. Kisseberth, Kaylee Nuckolls, David M. Vail, Chand Khanna, Susan E. Lana, Samuel Yalkowsy
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 6, p e11013 (2010)
PLoS ONE, Vol 5, Iss 6, p e11013 (2010)
Background: Signaling through the mTOR pathway contributes to growth, progression and chemoresistance of several cancers. Accordingly, inhibitors have been developed as potentially valuable therapeutics. Their optimal development requires considerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ee6c2191449e8544354253cd49f03a
http://europepmc.org/articles/PMC2882366
http://europepmc.org/articles/PMC2882366
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 6, p e10995 (2010)
PLoS ONE, Vol 5, Iss 6, p e10995 (2010)
Background Cell proliferation in all rapidly renewing mammalian tissues follows a circadian rhythm that is often disrupted in advanced-stage tumors. Epidemiologic studies have revealed a clear link between disruption of circadian rhythms and cancer d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aea3c0cd3aa2c37f68dd52e9542e1be
http://europepmc.org/articles/PMC2881876
http://europepmc.org/articles/PMC2881876
Publikováno v:
PLoS ONE
PloS one, 6 (2
PLoS ONE, Vol 6, Iss 2, p e14710 (2011)
PloS one, 6 (2
PLoS ONE, Vol 6, Iss 2, p e14710 (2011)
Gastrointestinal stromal tumors (GIST) are thought to derive from the interstitial cells of Cajal (ICC) or an ICC precursor. Oncogenic mutations of the KIT or PDGFRA receptor tyrosine kinases are present in the majority of GIST, leading to ligand-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a1da06a0496ed4062120af71edaece
https://pubmed.ncbi.nlm.nih.gov/21364741
https://pubmed.ncbi.nlm.nih.gov/21364741
Autor:
Lara Milane, Mansoor M. Amiji, Keinosuke Ryu, Michiro Susa, Henry J. Mankin, Edwin Choy, Arun K. Iyer, Zhenfeng Duan, Francis J. Hornicek
Publikováno v:
PloS one, vol 5, iss 5
PLoS ONE
PLoS ONE, Vol 5, Iss 5, p e10764 (2010)
PLoS ONE
PLoS ONE, Vol 5, Iss 5, p e10764 (2010)
Background The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients' average 5 year survival rate from 20% to 70% in the past 30 years. However, for patients who progress after chemotherapy, its effectiveness diminishes due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d450bf1922598a2a0a7ec654740ba8b
https://escholarship.org/uc/item/2c8006k0
https://escholarship.org/uc/item/2c8006k0