Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Oncogene RET"'
IMPLICAÇÕES CLÍNICAS DO DIAGNÓSTICO MOLECULAR NO MANEJO DO CARCINOMA MEDULAR DE TIREÓIDE HEREDITÁRIO
Publikováno v:
Clinical and Biomedical Research, Vol 23, Iss 1 - 2 (2022)
O carcinoma medular de tireóide (CMT) hereditário pode apresentar-se como componente das síndromes de Neoplasia Endócrina Múltipla (NEM 2A e 2B) ou Carcinoma Medular de Tireóide Familiar (CMTF). Diferentes mutações no RET foram identificadas
Externí odkaz:
https://doaj.org/article/38b3d9acc66b46dab905ba0691917be7
Akademický článek
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Publikováno v:
Alʹmanah Kliničeskoj Mediciny, Vol 44, Iss 4, Pp 535-539 (2016)
This article provides our own clinical observation of the patient with multiple endocrine neoplasia type 2B (MEN2B) associated with a germinal mutation in the RET proto-oncogene. Although there are highly informative laboratory methods available, in
Externí odkaz:
https://doaj.org/article/e32fa037f0a4481bae88bda500114e2d
IMPLICAÇÕES CLÍNICAS DO DIAGNÓSTICO MOLECULAR NO MANEJO DO CARCINOMA MEDULAR DE TIREÓIDE HEREDITÁRIO
Publikováno v:
Clinical & Biomedical Research; Vol. 23 No. 1-2 (2003): Revista HCPA
Clinical and Biomedical Research; v. 23 n. 1-2 (2003): Revista HCPA
Clinical and Biomedical Research
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Clinical and Biomedical Research; v. 23 n. 1-2 (2003): Revista HCPA
Clinical and Biomedical Research
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Hereditary MTC can occur either alone – familial MTC (FMTC) – or as the thyroid manifestation of multiple endocrine neoplasia type 2 (MEN 2) syndromes (MEN 2A and MEN 2B) or others. Three phenotypic subtypes have been reported. MEN 2A(1), MEN 2A(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0ac237dab880b802f8277d4824b8d4f6
https://seer.ufrgs.br/index.php/hcpa/article/view/126198
https://seer.ufrgs.br/index.php/hcpa/article/view/126198
Publikováno v:
Chinese Journal of Chemistry. 38:1656-1662
Autor:
Satomi Noguchi, Kei Yamamoto, Yumi Soejima, Shinichi Suzuki, Seiichi Takenoshita, Izumi Nakamura, Mizuki Goto, Ken Ishioka, Noriko Ohtsuki, Takumi Era, Yokouchi Yuji, Satoru Suzuki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Many human diseases ranging from cancer to hereditary disorders are caused by single-nucleotide mutations in critical genes. Repairing these mutations would significantly improve the quality of life for patients with hereditary diseases. However, cur
Autor:
Chunxi Wang, Chunyang Cao, Renxiao Wang, Shaohua Huang, Wenxian Lan, Fei Wang, Yaping Liu, Hao Han
Publikováno v:
Chemical communications (Cambridge, England). 56(14)
G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is ext
Publikováno v:
Drugs of Today. 57:621
Aberrations in oncogene RET (rearranged during transfection) have been found to be the cause of different kinds of malignancies, especially in lung and thyroid cancers. Targeted therapy of RET-altered cancers using multi-kinase inhibitors (MKIs) has
Autor:
Silvana Pilotti, Angela Greco, Katia Todoerti, Loris De Cecco, Matteo Dugo, Maria Grazia Borrello, Paola Romeo, Ettore Seregni, Federica Perrone, Emanuela Minna, Luca Agnelli, Antonino Neri
Publikováno v:
Oncotarget
// Emanuela Minna 1 , Paola Romeo 1 , Matteo Dugo 2 , Loris De Cecco 2 , Katia Todoerti 3 , Silvana Pilotti 4 , Federica Perrone 4 , Ettore Seregni 5 , Luca Agnelli 6 , Antonino Neri 6, 7 , Angela Greco 1 , Maria Grazia Borrello 1 1 Department of Exp
Autor:
Ian S. Hagemann, Rebecca D. Chernock
Publikováno v:
American Journal of Clinical Pathology. 143:768-777
Objectives: Medullary thyroid carcinoma (MTC) is a relatively uncommon type of thyroid malignancy, with unique histologic features and molecular pathology. It is important to recognize, because its management, which is in part driven by the genetic b