Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Oncogene Proteins, Fusion/metabolism"'
2
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
Autor: Daan Dierickx, Philippe Gaulard, Carlos Graux, Koen Debackere, Laurence de Leval, Nicole Mentens, Jan Cools, Lucienne Michaux, Kris Jacobs, Thomas Tousseyn, Sofie Demeyer, Olga Gielen, Michaël Broux, Iwona Wlodarska, Marlies Vanden Bempt, Lukas Marcelis, Gregor Verhoef
Publikováno v: Nature communications, vol. 12, no. 1, pp. 3705
Nature communications, Vol. 12, no.1, p. 3705 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133ce4ef8eab96b32fc1be9ac3896731
https://doi.org/10.1038/s41467-021-24037-4
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3
Ewing's Sarcoma
Autor: Riggi, N., Suvà, M.L., Stamenkovic, I.
Publikováno v: The New England journal of medicine, vol. 384, no. 2, pp. 154-164
In 1920, during a meeting of the New York Pathological Society, James Ewing described an unusual tumor in a 14-year-old girl as a “diffuse endothelioma of bone.”1 The tumor had initially been diagnosed as an osteosarcoma, but its architecture, th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::4cf691af0fa211b0aa9a69856c713324
https://serval.unil.ch/resource/serval:BIB_D9FCD24578B0.P001/REF.pdf
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4
TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases
Autor: Rachel Deplus, Martine Duterque-Coquillaud, Anne Flourens, Edith Bonnelye, Nathalie Vanpouille, Tian V. Tian, Philippe Clézardin, Anais Fradet, Carine Delliaux, Xavier Leroy, Yvan de Launoit, Mathilde Bouchet, Arnauld Villers
Publikováno v: Cancer Letters
Cancer Letters, Elsevier, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
Cancer Letters, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
International audience; Abstract : Prostate cancers have a strong propensity to metastasize to bone and promote osteoblastic lesions. TMPRSS2:ERG is the most frequent gene rearrangement identified in prostate cancer, but whether it is involved in pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2efdc0696479c6db9b921256206c223
https://doi.org/10.1016/j.canlet.2018.08.027
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5
Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies
Autor: Ivan Stamenkovic, Miguel Rivera, Angela Volorio, Sowmya Iyer, Liliane C. Broye, Nicolo Riggi, Gaylor Boulay
Publikováno v: Genes & development, vol. 32, no. 15-16, pp. 1008-1019
Various types of repetitive sequences are dysregulated in cancer. In Ewing sarcoma, the oncogenic fusion protein EWS-FLI1 induces chromatin features typical of active enhancers at GGAA microsatellite repeats, but the function of these sites has not b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5970a5a72d1ba8518ad231ed454cdb0
https://pubmed.ncbi.nlm.nih.gov/30068701
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6
JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells
Autor: David Olmos, Zoë S. Walters, Edoardo Missiaglia, Bissan Al-Lazikani, Julian Blagg, Thomas Ws Buist, Michelle D. Garrett, Rebecca Allen, Janet Shipley, Barbara Villarejo-Balcells
Publikováno v: Oncogene
Oncogene, vol. 33, no. 9, pp. 1148-1157
Rhabdomyosarcomas (RMS) are the most frequent soft-tissue sarcoma in children and\ud characteristically show features of developing skeletal muscle. The alveolar subtype is frequently\ud associated with a PAX3-FOXO1 fusion protein that is known to co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6de3048cd3fbce55d8e97a5eabd4072
http://europepmc.org/articles/PMC3982124
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7
The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma
Autor: Victor Fernandes Vieira, Sandrine Cornaz, Luisa Cironi, Carlo Fusco, Paolo Provero, Giulia Fregni, Ivan Stamenkovic, Igor Letovanec, Michel Aguet, Tanja Petricevic
Publikováno v: Scientific Reports
Scientific reports, vol. 6, pp. 22113
Expression of the SS18/SYT-SSX fusion protein is believed to underlie the pathogenesis of synovial sarcoma (SS). Recent evidence suggests that deregulation of the Wnt pathway may play an important role in SS but the mechanisms whereby SS18-SSX might
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60efadcc1928d9d1f484ba21cc89d788
https://doi.org/10.1038/srep22113
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8
Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2
Autor: Tian V. Tian, Y. De Launoit, Xavier Leroy, Ludovic Huot, Nathalie Tomavo, Martine Duterque-Coquillaud, Anne Flourens, Sébastien Flajollet, Edith Bonnelye, David Hot
Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2014, 33 (17), pp.2204-2214. ⟨10.1038/onc.2013.176⟩
Oncogene, 2014, 33 (17), pp.2204-2214. ⟨10.1038/onc.2013.176⟩
International audience; Prostate cancer (PCa) is one of the major public health problems in Western countries. Recently, the TMPRSS2:ERG gene fusion, which results in the aberrant expression of the transcription factor ERG, has been shown to be the m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d576f6a8be17c3a0773fdc727480c1
https://hal.archives-ouvertes.fr/hal-02353391
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9
IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells
Autor: Nicolo Riggi, Luisa Cironi, Domizio Suva, Paolo Provero, Natalie Wolf, Mario-Luca Suvà, Vincent Kindler, Ivan Stamenkovic
Publikováno v: PLoS ONE, Vol 3, Iss 7, p e2634 (2008)
PLoS ONE
PloS one, vol. 3, no. 7, pp. e2634
BACKGROUND: The EWS-FLI-1 fusion protein is associated with 85-90% of Ewing's sarcoma family tumors (ESFT), the remaining 10-15% of cases expressing chimeric genes encoding EWS or FUS fused to one of several ets transcription factor family members, i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589b3b4f9bcc223671260e924488d061
http://europepmc.org/articles/PMC2481291?pdf=render
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