Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.

Autor: Chana CK; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Maisonneuve P; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Posternak G; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Grinberg NGA; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Poirson J; Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Ona SM; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Ceccarelli DF; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Mader P; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., St-Cyr DJ; X-Chem Inc., Montréal, Québec H4S 1Z9, Canada., Pau V; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, Illinois 60439, United States., Tang X; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Deng D; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Cui W; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Su W; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Kuai L; WuXi AppTec, 55 Cambridge Parkway, 8th Floor, Cambridge, Massachusetts 02142, United States., Soll R; WuXi AppTec, 55 Cambridge Parkway, 8th Floor, Cambridge, Massachusetts 02142, United States., Tyers M; Institute for Research in Immunology and Cancer, University of Montréal, Québec H3C 3J7, Canada., Röst HL; Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.; Department of Computer Science, University of Toronto, Toronto, Ontario M5S 2E4, Canada., Batey RA; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada., Taipale M; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Sicheri F; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Oct 13; Vol. 65 (19), pp. 12725-12746. Date of Electronic Publication: 2022 Sep 18.

A substrate binding model for the KEOPS tRNA modifying complex.

Autor: Beenstock J; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Ona SM; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Porat J; Department of Biology, York University, Toronto, ON, Canada., Orlicky S; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Wan LCK; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Ceccarelli DF; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Maisonneuve P; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Szilard RK; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Yin Z; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Setiaputra D; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Mao DYL; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Khan M; Department of Chemistry, University of Calgary, Calgary, AB, Canada., Raval S; Department of Chemistry, University of Calgary, Calgary, AB, Canada., Schriemer DC; Department of Chemistry, University of Calgary, Calgary, AB, Canada.; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada., Bayfield MA; Department of Biology, York University, Toronto, ON, Canada., Durocher D; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Sicheri F; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.

Publikováno v: Nature communications [Nat Commun] 2020 Dec 04; Vol. 11 (1), pp. 6233. Date of Electronic Publication: 2020 Dec 04.