Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ona L. McConnell"'
Autor:
Kaalak Reddy, Jana R. Jenquin, J. Andrew Berglund, Maja C Haerle, Eric T. Wang, Jared I Richardson, Belinda S. Pinto, Lori Planco, John D. Cleary, Ona L. McConnell, Masayuki Nakamori, Elizabeth Delgado
Publikováno v:
Proceedings of the National Academy of Sciences. 116:20991-21000
A CTG repeat expansion in the DMPK gene is the causative mutation of myotonic dystrophy type 1 (DM1). Transcription of the expanded CTG repeat produces toxic gain-of-function CUG RNA, leading to disease symptoms. A screening platform that targets pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90034b385d59f4be2d3161ceb530b19
https://doi.org/10.1073/pnas.1901893116
https://doi.org/10.1073/pnas.1901893116
Autor:
Melissa Hale, Berglund Ja, Ona L. McConnell, Ellis Ja, McDaniel S, Amy E. Mahady, Ryan Meng, Jared I Richardson, Stacey D. Wagner
Alternative splicing (AS) is controlled by cis-regulatory elements recognized by networks of trans-acting factors. Here we investigate modes and mechanisms of AS co-regulation by MBNL1 and RBFOX1, two RNA binding proteins (RBPs) critical for developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec9c088cba8de2d729d8d92e9ae42e28
https://doi.org/10.1101/2021.04.20.440659
https://doi.org/10.1101/2021.04.20.440659
Autor:
Ona L. McConnell, Mighten C Yip, Andrew Jenkins, Riley E. Perszyk, Craig R. Forest, Stephen F. Traynelis, Eric T. Wang
Publikováno v:
Mol Pharmacol
Communication between neuronal cells, which is central to brain function, is performed by several classes of ligand-gated ionotropic receptors. The gold-standard technique for measuring rapid receptor response to agonist is manual patch-clamp electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf5dcdaefd351cbcb348f76f1914a4b
https://pubmed.ncbi.nlm.nih.gov/33958481
https://pubmed.ncbi.nlm.nih.gov/33958481
Publikováno v:
Oxford University Press
Nucleic Acids Research
Nucleic Acids Research
The Muscleblind (MBL) protein family is a deeply conserved family of RNA binding proteins that regulate alternative splicing, alternative polyadenylation, RNA stability and RNA localization. Their inactivation due to sequestration by expanded CUG rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905f001853d625cc34dca6d5ab799f71
https://doi.org/10.1093/nar/gkw735
https://doi.org/10.1093/nar/gkw735
Autor:
Héctor R. Méndez-Gómez, Ona L. McConnell, Tanvi Saxena, Maurice S. Swanson, Lance T. Denes, Guangbin Xia, Ruan Oliveira, Eric T. Wang, Juan Arboleda, John D. Cleary, Belinda S. Pinto
Publikováno v:
Molecular cell. 68(3)
SummaryTranscription of expanded microsatellite repeats is associated with multiple human diseases, including myotonic dystrophy, Fuchs’ endothelial corneal dystrophy, andC9orf72-ALS/FTD. Eliminating or reducing production of RNA and proteins arisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4d7ff1256ac3896b63e289478ded64
https://pubmed.ncbi.nlm.nih.gov/29056323
https://pubmed.ncbi.nlm.nih.gov/29056323
Autor:
Ryan C Day, Melissa Hale, Jared I Richardson, Juan Arboleda, J. Andrew Berglund, Ona L. McConnell, Eric T. Wang
Publikováno v:
Nucleic Acids Research
The muscleblind-like (MBNL) family of proteins are key developmental regulators of alternative splicing. Sequestration of MBNL proteins by expanded CUG/CCUG repeat RNA transcripts is a major pathogenic mechanism in the neuromuscular disorder myotonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e8f4304e715056928a3598bacb8e0a
https://pubmed.ncbi.nlm.nih.gov/29309648
https://pubmed.ncbi.nlm.nih.gov/29309648
Autor:
Amanda A. H. Freeman, A. Jenkins, Eric T. Wang, David B. Rye, Prabhjyot Saini, Gary J. Bassell, Lynn Marie Trotti, O. Moody, Ona L. McConnell
Publikováno v:
Sleep Medicine. 40:e285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66bd27d22bc1831a8bd3297f08e6a66b
https://doi.org/10.1016/j.sleep.2017.11.836
https://doi.org/10.1016/j.sleep.2017.11.836