In silico discovery of small molecules for efficient stem cell differentiation into definitive endoderm

Autor: Novakovsky, Gherman, Sasaki, Shugo, Fornes, Oriol, Omur, Meltem E., Huang, Helen, Bayly, Carmen L., Zhang, Dahai, Lim, Nathaniel, Cherkasov, Artem, Pavlidis, Paul, Mostafavi, Sara, Lynn, Francis C., Wasserman, Wyeth W.

Publikováno v: In Stem Cell Reports 14 March 2023 18(3):765-781

An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer.

Autor: Davies A; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Nouruzi S; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Ganguli D; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Namekawa T; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Thaper D; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Linder S; The Netherlands Cancer Institute, Oncode Institute, Amsterdam, The Netherlands., Karaoğlanoğlu F; Vancouver Prostate Centre, Vancouver, British Columbia, Canada.; School of Computing Science, Simon Fraser University, Burnaby, British Columbia, Canada., Omur ME; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Kim S; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Kobelev M; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Kumar S; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Sivak O; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Bostock C; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Bishop J; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Hoogstraat M; The Netherlands Cancer Institute, Oncode Institute, Amsterdam, The Netherlands., Talal A; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Stelloo S; The Netherlands Cancer Institute, Oncode Institute, Amsterdam, The Netherlands., van der Poel H; The Netherlands Cancer Institute, Oncode Institute, Amsterdam, The Netherlands., Bergman AM; The Netherlands Cancer Institute, Oncode Institute, Amsterdam, The Netherlands., Ahmed M; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Fazli L; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Huang H; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA., Tilley W; Dame Roma Mitchell Cancer Research Labs, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia., Goodrich D; Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA., Feng FY; Department of Urology, University of California San Francisco, San Francisco, CA, USA., Gleave M; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., He HH; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Hach F; Vancouver Prostate Centre, Vancouver, British Columbia, Canada.; School of Computing Science, Simon Fraser University, Burnaby, British Columbia, Canada., Zwart W; The Netherlands Cancer Institute, Oncode Institute, Amsterdam, The Netherlands., Beltran H; Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Selth L; Dame Roma Mitchell Cancer Research Labs, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.; Dame Roma Mitchell Cancer Research Labs and Freemasons Centre for Male Health and Wellbeing, Adelaide Medical School, University of Adelaide, Adelaide, Australia.; Flinders Health and Medical Research Institute, Flinders University, College of Medicine and Public Health, Bedford Park, Australia., Zoubeidi A; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada. azoubeidi@prostatecentre.com.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada. azoubeidi@prostatecentre.com.

Publikováno v: Nature cell biology [Nat Cell Biol] 2021 Sep; Vol. 23 (9), pp. 1023-1034. Date of Electronic Publication: 2021 Sep 06.