Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Omozuanvbo Aisiku"'
Autor:
Robert Flaumenhaft, Monicah A. Otieno, Calvert Louden, A.D. van der Meer, Donald E. Ingber, Tadanori Mammoto, Omozuanvbo Aisiku, K. De Ceunynck, Geraldine A. Hamilton, Akiko Mammoto, Abhishek Jain, Riccardo Barrile
Publikováno v:
Clinical pharmacology & therapeutics, 103(2), 332-340. Wiley-Blackwell
Pulmonary thrombosis is a significant cause of patient mortality, however, there are no effective in vitro models of thrombi formation in human lung microvessels, that could also assess therapeutics and toxicology of antithrombotic drugs. Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0024a11e5ba3e3634e36f6ace233af
https://research.utwente.nl/en/publications/c7ea1dba-3262-4dcd-9821-f831145a2c11
https://research.utwente.nl/en/publications/c7ea1dba-3262-4dcd-9821-f831145a2c11
Autor:
Christian G. Peters, Sarah J. Higgins, Robert Flaumenhaft, Omozuanvbo Aisiku, Jennifer L. Fitch-Tewfik, Karen De Ceunynck, Donald E. Ingber, Sharjeel A. Chaudhry, Chris Dockendorff, Abhishek Jain, Samir M. Parikh
Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing. Clinical use of APC, however, is l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c14a22828d5f1ac2b94559e83eaaa7
https://europepmc.org/articles/PMC5798377/
https://europepmc.org/articles/PMC5798377/
Autor:
Christian G. Peters, Mingdong Huang, Samir M. Parikh, Robert Flaumenhaft, James R. Dilks, Chris Dockendorff, Chandra C. Ghosh, Karen De Ceunynck, Omozuanvbo Aisiku, S. F. Fustolo-Gunnink
Publikováno v:
Blood. 125:1976-1985
Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias. Its activation by thrombin stimu
Autor:
Robert Flaumenhaft, Jurandir J. Dalle Lucca, George C. Tsokos, Omozuanvbo Aisiku, Nathan I. Shapiro, Carl J. Hauser, Gelareh Atefi
Publikováno v:
Shock (Augusta, Ga.). 46(3 Suppl 1)
Trauma remains the main cause of death for both civilians and those in uniform. Trauma-associated coagulopathy is a complex process involving inflammation, coagulation, and platelet dysfunction. It is unknown whether activation of complement, which o
Autor:
Omozuanvbo Aisiku, Robert Flaumenhaft, Karen De Ceunynck, Abhishek Jain, Geraldine A. Hamilton, Andries D. van der Meer, Calvert Louden, Donald E. Ingber, Monicah A. Otieno, Riccardo Barrile
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
Pulmonary microvascular thrombosis is a catastrophic medical condition and yet, it is very difficult to predict response and study mechanism of action of potential drug candidates to humans. This is partly so because currently available in vitro assa
Autor:
Christian G. Peters, Robert Flaumenhaft, Thierry Galli, Lydia Danglot, Secil Koseoglu, Omozuanvbo Aisiku, Jennifer L. Fitch-Tewfik
Publikováno v:
Blood
Blood, American Society of Hematology, 2015, 126 (5), pp.651-60. ⟨10.1182/blood-2014-12-618744⟩
Blood, American Society of Hematology, 2015, 126 (5), pp.651-60. ⟨10.1182/blood-2014-12-618744⟩
International audience; Platelet activation results in profound morphologic changes accompanied by release of granule contents. Recent evidence indicates that fusion of granules with the plasma membrane during activation provides auxiliary membrane t
Autor:
Samir M. Parikh, Sarah J. Higgins, Omozuanvbo Aisiku, Chris Dockendorff, Jennifer L. Fitch-Tewfik, Christian G. Peters, Karen De Ceunynck, Abhishek Jain, Donald E. Ingber, Sharjeel A. Chaudhry, Robert Flaumenhaft
Publikováno v:
Blood. 128:3835-3835
Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in animal models of inflammation and APC has been used clinically in sepsis and wound healing. Clinical use of APC in sepsis, however, was t
Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor
Autor:
Chris Dockendorff, Lynn VerPlank, Joseph Negri, Daniel A. Smith, Robert Flaumenhaft, Stuart L. Schreiber, James R. Dilks, Louisa Dowal, Michelle Palmer, Lawrence MacPherson, Omozuanvbo Aisiku, Susanna F. Gunnink
Publikováno v:
ACS Medicinal Chemistry Letters
A high-throughput screen of the NIH-MLSMR compound collection, along with a series of secondary assays to identify potential targets of hit compounds, previously identified a 1,3-diaminobenzene scaffold that targets protease-activated receptor 1 (PAR
Activation of phospholipase Cβ (PLCβ) by G proteins leads to a chain of events that result in an increase in intracellular calcium and activation of protein kinase C (PKC). It has been found that PKC phosphorylates PLCβ1 on S887 in vitro without a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52415607b573f42209dc968b516d5ba
https://europepmc.org/articles/PMC3081424/
https://europepmc.org/articles/PMC3081424/
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15001 (2010)
PLoS ONE
PLoS ONE
Mammalian phospholipase Cβ1 (PLCβ1) is activated by the ubiquitous Gα(q) family of G proteins on the surface of the inner leaflet of plasma membrane where it catalyzes the hydrolysis of phosphatidylinositol 4,5 bisphosphate. In general, PLCβ1 is