Výsledky vyhledávání

Abstract 2296: Validation of a novel one-step digital PCR platform with precision circulating cell-free DNA standards

Autor: Omo Clement, Andrew Zayac, Steve Gallagher, Megan E. Dueck, Andrew Anfora, Robert Lin, Dana Ruminsky-Lowe, Paul J. Hung

Publikováno v: Cancer Research. 79:2296-2296

In this study we demonstrate precision quantification of Seraseq ctDNA EGFR T790M mutation mix at AF0.1% (mutant/wild-type ratio) using a novel one-step digital PCR (dPCR) platform. This novel yet simple workflow has the potential to make cancer liqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9c77ee58d4fd7555193a0571769c8ba
https://doi.org/10.1158/1538-7445.am2019-2296

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Abstract 1364: A Non-Small Cell Lung Cancer Reference Material

Autor: Farol L. Tomson, Catherine Huang, Omo Clement, Russell Garlick, Bharathi Anekella

Publikováno v: Cancer Research. 79:1364-1364

Lung cancer is the leading cause of cancer death in the United States as well as globally. The major diagnosis (~85%) of lung cancer patients is non-small cell lung carcinoma (NSCLC). About 10-50% of NSCLCs have several activating EGFR driver mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dace98cd29669c7f3043e634b168da05
https://doi.org/10.1158/1538-7445.am2019-1364

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Abstract 3167: Improving and standardizing TMB assay performance

Autor: Matthew G. Butler, Yves Konigshofer, Lequan Nguyen, Shikha Kalotra, Omo Clement, Russell K. Garlick, Bharathi Anekella

Publikováno v: Cancer Research. 79:3167-3167

Determining and using the most effective and safest treatment is of great importance in cancer disease management. Checkpoint inhibitors that target immune regulatory molecules such as PD-1, PD-L1, and CTLA-4, have successfully improved PFS and OS -

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1043c98c2a9915edd328afb4098ab0d0
https://doi.org/10.1158/1538-7445.am2019-3167

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Following Nature's Lead: Generating Compounds for Stabilizing Biomolecules

Autor: Scott Whitney, Judy Muller-Cohn, Rolf Müller, Omo Clement

Publikováno v: Biopreservation and Biobanking. 10:395-402

We describe here a unique approach to identifying small molecules that are useful in stabilizing biomolecules in the dry and liquid states. Using biostability screens aided by in silico docking experiments and synthetic chemistry, libraries of biosta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c5161b76a35b0b07fc2c3c8960b142
https://doi.org/10.1089/bio.2012.0022

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Abstract 4894: Targeted sequencing of myeloid cancers using single-molecule enrichment in picodroplets

Autor: Michael L. Samuels, Jeffrey L. Olson, Steve K. Kotsopoulos, Holly Gettler, Omo Clement, Frances Long

Publikováno v: Cancer Research. 75:4894-4894

A new method for enrichment of targeted genomic regions for next generation sequencing (NGS) is the use of single-molecule formatted PCR amplification, with the sample's target DNA partitioned into uniform picoliter volume droplets such that there ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f08d5ce3e3978ab3a161a199f3e3993b
https://doi.org/10.1158/1538-7445.am2015-4894

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