Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Omneya M. Khalil"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Our main goal was to design and synthesize novel lomefloxacin derivatives that inhibit the topoisomerase II enzyme, leading to potent anticancer activity. Lomefloxacin derivatives substituted at position 3 and 7 were synthesized and screened
Externí odkaz:
https://doaj.org/article/2fbf5fd5b614407889839bd707ebe0dd
Publikováno v:
Medicinal Chemistry. 18:903-914
Background: Breast cancer is currently the leading cause of worldwide cancer incidence exceeding lung cancer. In addition, breast cancer accounts for 1 in 4 cancer cases and 1 in 6 cancer deaths among women. Cytotoxic chemotherapy is still the main t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7fcd9452a7d4352b396e874a9d391e
https://doi.org/10.2174/1573406418666220309123648
https://doi.org/10.2174/1573406418666220309123648
Publikováno v:
Bioorganic Chemistry. 83:262-276
Aim Design and synthesis of novel nalidixic acid derivatives of potent anticancer and topoisomerase II inhibitory activities were our major aim. Materials & methods All the newly synthesized nalidixic acid derivatives were submitted to the National C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0c1e1c99567b1c0d0d6a52e57ec9d0
https://doi.org/10.1016/j.bioorg.2018.10.058
https://doi.org/10.1016/j.bioorg.2018.10.058
Publikováno v:
Archiv der Pharmazie. 355:2200326
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) designed to be a selective cyclooxygenase-2 (COX-2) inhibitor. It was approved by the U.S. Food and Drug Administration for the treatment of inflammatory diseases such as osteoarthritis and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ec84d0c0d23159d36ec5d79b5cef43
https://doi.org/10.1002/ardp.202200326
https://doi.org/10.1002/ardp.202200326
Publikováno v:
Archiv der Pharmazie. 355:2200190
Series of new celecoxib analogs were synthesized to assess their anticancer activity against the MCF-7 cell line. Four compounds, 3a, 3c, 5b, and 5c, showed 1.4-9.2-fold more potent anticancer activity than celecoxib. The antiproliferative activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292546de94f9c382969ef556fb016c28
https://doi.org/10.1002/ardp.202200190
https://doi.org/10.1002/ardp.202200190
Autor:
Heba El Sayed Teba, Aliaa M. Kamal, Claudiu T. Supuran, Silvia Bua, Omneya M. Khalil, Yassin M. Nissan
Publikováno v:
European journal of medicinal chemistry. 188
A series of novel sulfonamide derivatives bearing pyrrole and pyrrolopyrimidine scaffolds were synthesized and screened as carbonic anhydrase inhibitors. The inhibition activity of the synthesized compounds was evaluated against the cytosolic human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081ba56d16fadfa257949b476747ea7e
https://pubmed.ncbi.nlm.nih.gov/31901743
https://pubmed.ncbi.nlm.nih.gov/31901743
Publikováno v:
OALib. :1-7
The present study focused on synthesizing a series of novel derivatives of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl) acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97432621d7916c38275985134f583640
https://doi.org/10.4236/oalib.1102876
https://doi.org/10.4236/oalib.1102876
Publikováno v:
Acta Chimica Slovenica, Vol 64, Iss 1, Pp 102-116 (2017)
A new series of 4-benzyl-6,7,8,9-tetrahydro[1]benzothieno[3,2- e ][1,2,4]triazolo[4,3- a ] pyrimidines was synthesized motivated by the widely reported anticancer activity of thieno[2,3- d ]pyrimidines and triazolothienopyrimidines. The in vitro cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbba2f36f3ddee76fc1cc392a2a1e7c
https://pubmed.ncbi.nlm.nih.gov/28380219
https://pubmed.ncbi.nlm.nih.gov/28380219
Publikováno v:
Journal of Chemical Research. 36:480-483
The synthesis and characterisation of novel tricyclic systems containing a fused thieno[3,4-d]pyrimidine nucleus starting from a useful synthon, ethyl-4-cyano-3-ethoxymethyleneamino-5-phenylamino-2-thiophenecarboxylate, are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b027a5d1171a3f9253da39b655840c74
https://doi.org/10.3184/174751912x13400242909892
https://doi.org/10.3184/174751912x13400242909892
Autor:
Omneya M. Khalil
Publikováno v:
Medicinal Chemistry Research. 21:3240-3245
A series of novel pyrazoline derivatives containing 4-morpholinophenyl moiety were synthesized to investigate their potential anti-inflammatory activity. The chemical structures of the compounds were elucidated by spectral data and element analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91744164efafe86cbfe3aeec2b36d966
https://doi.org/10.1007/s00044-011-9862-3
https://doi.org/10.1007/s00044-011-9862-3