Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Omid Tavassoly"'
Autor:
Morgan Bérard, Razan Sheta, Sarah Malvaut, Raquel Rodriguez-Aller, Maxime Teixeira, Walid Idi, Roxanne Turmel, Melanie Alpaugh, Marilyn Dubois, Manel Dahmene, Charleen Salesse, Jérôme Lamontagne-Proulx, Marie-Kim St-Pierre, Omid Tavassoly, Wen Luo, Esther Del Cid-Pellitero, Raza Qazi, Jae-Woong Jeong, Thomas M Durcan, Luc Vallières, Marie-Eve Tremblay, Denis Soulet, Martin Lévesque, Francesca Cicchetti, Edward A Fon, Armen Saghatelyan, Abid Oueslati
Publikováno v:
PLoS Biology, Vol 20, Iss 3, p e3001578 (2022)
Neurodegenerative disorders refer to a group of diseases commonly associated with abnormal protein accumulation and aggregation in the central nervous system. However, the exact role of protein aggregation in the pathophysiology of these disorders re
Externí odkaz:
https://doaj.org/article/2345db5e865f4420afb480af79493bdb
Publikováno v:
Open Biology, Vol 8, Iss 1 (2018)
The accumulation of various metabolites appears to be associated with diverse human diseases. However, the aetiological link between metabolic alteration and the observed diseases is still elusive. This includes the correlation between the abnormally
Externí odkaz:
https://doaj.org/article/a021aabc6e23426ab7032493a6366255
Autor:
Thomas M. Durcan, Eddie Cai, Wen Luo, Frédérique Larroquette, Rhalena A. Thomas, Omid Tavassoly, Edward A. Fon, Esther Del Cid Pellitero, Vincent Soubannier
Publikováno v:
Neurotherapeutics
Aggregation and deposition of α-synuclein (α-syn) in Lewy bodies within dopamine neurons of substantia nigra (SN) is the pathological hallmark of Parkinson’s disease (PD). These toxic α-syn aggregates are believed to propagate from neuron-to-neu
Autor:
Morgan Bérard, Razan Sheta, Sarah Malvaut, Raquel Rodriguez-Aller, Maxime Teixeira, Walid Idi, Roxanne Turmel, Melanie Alpaugh, Marilyn Dubois, Manel Dahmene, Charleen Salesse, Jérôme Lamontagne-Proulx, Marie-Kim St-Pierre, Omid Tavassoly, Wen Luo, Esther Del Cid-Pellitero, Raza Qazi, Jae-Woong Jeong, Thomas M. Durcan, Luc Vallières, Marie-Eve Tremblay, Denis Soulet, Martin Lévesque, Francesca Cicchetti, Edward A. Fon, Armen Saghatelyan, Abid Oueslati
Publikováno v:
PLoS biology. 20(3)
Neurodegenerative disorders refer to a group of diseases commonly associated with abnormal protein accumulation and aggregation in the central nervous system. However, the exact role of protein aggregation in the pathophysiology of these disorders re
Publikováno v:
ACS Chemical Neuroscience
Postinfection complications of coronavirus disease 2019 (COVID-19) are still unknown, and one of the long-term concerns in infected people are brain pathologies. The question is that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infect
Autor:
Omid Tavassoly, Iman Tavassoly
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] The delivery of hydrophobic therapeutic agents to tumors is a challenge in the treatment of cancers. Here, we review recent advances in coiled-coil protein origami and discuss a proposed programmable protein origami structure, switc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8c0c0161ad1b050fb6dd9b7abe5cf2
https://europepmc.org/articles/PMC8369664/
https://europepmc.org/articles/PMC8369664/
Autor:
Omid Tavassoly, Iman Tavassoly
Publikováno v:
ACS chemical neuroscience. 12(11)
Recent findings showed that preformed fibrils (PFFs) of misfolded proteins, including α-synuclein (α-syn) and amyloid-β (Aβ), activate EGFR in cell cultures and animal models of amyloid propagation. Comparing these supramolecular structures to no
Autor:
Jean-François Trempe, Omid Tavassoly, Karen Marder, Patrick A. Dion, Edward A. Fon, Roy N. Alcalay, Petra Oliva, Un Jung Kang, Xiaokui Kate Zhang, Mélanie Langlois, Richard Y.J. Wu, Cheryl Waters, Sandra B. Laurent, Claire S. Leblond, Nicolas Dupré, Christopher Liong, Jennifer A. Ruskey, Wendy K. Chung, Sheng-Han Kuo, Blair Ford, Oren A. Levy, Lorraine N. Clark, Alexandre Dionne-Laporte, Pavlina Wolf, Amirthagowri Ambalavanan, Ziv Gan-Or, Benoît Vanderperre, Yves Dauvilliers, Victoria Mallett, Guy A. Rouleau, Dan Spiegelman, Sharon Hassin-Baer, Stanley Fahn, Lior Greenbaum
Publikováno v:
Movement Disorders. 34:526-535
Background: SMPD1 (acid-sphingomyelinase) variants have been associated with Parkinson's disease in recent studies. The objective of this study was to further investigate the role of SMPD1 mutations in PD. Methods: SMPD1 was sequenced in 3 cohorts (I
Autor:
Martin Lévesque, Edward A. Fon, Francesca Cicchetti, Thomas M. Durcan, Charleen Salesse, Sarah Malvaut, Omid Tavassoly, Marilyn Dubois, Walid Idi, Jérôme Lamontagne-Proulx, Raquel Rodriguez-Aller, Wen Luo, Abid Oueslati, Marie-Ève Tremblay, Maxime Teixeira, Morgan Bérard, Raza Qazi, Marie-Kim St-Pierre, Jae-Woong Jeong, Esther Del Cid-Pellitero, Razan Sheta, Denis Soulet, Roxanne Turmel, Manel Dahmene, Melanie Alpaugh, Luc Vallières, Armen Saghatelyan
Publikováno v:
SSRN Electronic Journal.
α-Synuclein (α-syn) aggregation into insoluble deposits, referred to as Lewy bodies (LBs), is the paramount pathological hallmark of Parkinson’s disease (PD) and related α-synucleinopathies. However, the mechanism by which these aggregates contr
Publikováno v:
Mol Pharmacol
Molecular Pharmacology
Molecular Pharmacology
Heparan sulfate proteoglycans (HSPGs) are cell surface receptors that are involved in the cellular uptake of pathologic amyloid proteins and viruses, including the novel coronavirus; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hepar