Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Omid Tavana"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The clinical success of restoring P53 for cancer therapy has been limited due to toxicity. Here, the authors identify USP2 as an upstream regulator of VPRBP-mediated degradation of p53 and PD-L1 and demonstrate the efficacy of combining USP2 inhibito
Externí odkaz:
https://doaj.org/article/43be5a3e2d67472bb2b43a925529767b
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-9 (2018)
Abstract Background It has been reported that USP7 (ubiquitin-specific protease 7) prevents ubiquitylation and degradation of DNA methyltransferase 1 (DNMT1) by direct binding of USP7 to the glycine-lysine (GK) repeats that join the N-terminal regula
Externí odkaz:
https://doaj.org/article/43e53c26a665441bbe4d44e014172d86
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
NRF2 (nuclear factor erythroid 2-related factor 2) is a transcription factor which plays a major role in oxidative stress responses by regulating antioxidant gene expression. We have recently identified the ARF tumor suppressor as a key regulator of
Externí odkaz:
https://doaj.org/article/22c62b815d754d82ac270be390b52ce7
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
Figure S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444106ead769434517a6030981d594b4
https://doi.org/10.1158/1078-0432.22476393.v1
https://doi.org/10.1158/1078-0432.22476393.v1
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
contains methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f66d7cdc5a26035ed01be67bc7dad53
https://doi.org/10.1158/1078-0432.22476381.v1
https://doi.org/10.1158/1078-0432.22476381.v1
OTUB1 is overexpressed in human cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0962ed9f8ee784ad144220093655d2
https://doi.org/10.1158/0008-5472.22422516
https://doi.org/10.1158/0008-5472.22422516
Although cell-cycle arrest, senescence, and apoptosis are established mechanisms of tumor suppression, accumulating evidence reveals that ferroptosis, an iron-dependent, nonapoptotic form of cell death, represents a new regulatory pathway in suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::418344fb52cff7a0e81d6ccbb0300051
https://doi.org/10.1158/0008-5472.c.6511251.v1
https://doi.org/10.1158/0008-5472.c.6511251.v1
These extra data provide additional evidence indicating the crucial role of Peli1 in modulating the activities of Mdmx and p53.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d29e1b1220c6f3dd67aa09578ce0b1
https://doi.org/10.1158/0008-5472.22418655.v1
https://doi.org/10.1158/0008-5472.22418655.v1
Mdm2 and Mdmx, both major repressors of p53 in human cancers, are predominantly localized to the nucleus and cytoplasm, respectively. The mechanism by which subcellular localization of Mdmx is regulated remains unclear. In this study, we identify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6151bd52c2d10060cd2bd7255624ad
https://doi.org/10.1158/0008-5472.c.6510186.v1
https://doi.org/10.1158/0008-5472.c.6510186.v1
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
Purpose:Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2–selective inhibitor, has had success in the clinic, another family member, Bcl-xL, has also em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8844690ddeffa8863fd595c34c80f01
https://doi.org/10.1158/1078-0432.c.6529392
https://doi.org/10.1158/1078-0432.c.6529392