Zobrazeno 1 - 10
of 403
pro vyhledávání: '"Omer Kucuk"'
Autor:
Mohamed Alaama, Omer Kucuk, Birdal Bilir, Ahmed Merzouk, Abbas Mohammad Ghawi, Mukerrem Betul Yerer, Mohamed Alaa Ahmado, Abdualrahman Mohammed Abdualkader, A.B.M. Helaluddin
Publikováno v:
Pharmacological Research - Modern Chinese Medicine, Vol 10, Iss , Pp 100355- (2024)
Introduction: Leech extract contains many identified bioactive substances which have a variety of biological effects. Leech extract was discovered in the late 19th century and since then many pharmaceutical products have been produced using leech ext
Externí odkaz:
https://doaj.org/article/9e7aa2f1fbe54f549016fefd1fc2528c
Autor:
Lijuan Bai, Xin Li, Yang Yang, Rui Zhao, Elshaddai Z. White, Alira Danaher, Nathan J. Bowen, Cimona V. Hinton, Nicholas Cook, Dehong Li, Alyssa Y. Wu, Min Qui, Yuhong Du, Haian Fu, Omer Kucuk, Daqing Wu
Publikováno v:
Translational Oncology, Vol 34, Iss , Pp 101707- (2023)
Chemoresistance is a major obstacle in the clinical management of metastatic, castration-resistant prostate cancer (PCa). It is imperative to develop novel strategies to overcome chemoresistance and improve clinical outcomes in patients who have fail
Externí odkaz:
https://doaj.org/article/84a2284d1e024c788c4eb028b30b0e80
Autor:
Dylan J. Martini, T. Anders Olsen, Subir Goyal, Yuan Liu, Sean T. Evans, Emilie Elise Hitron, Greta Anne Russler, Lauren Yantorni, Sarah Caulfield, Jacqueline T. Brown, Jamie M. Goldman, Bassel Nazha, Bradley C. Carthon, Wayne B. Harris, Omer Kucuk, Viraj A Master, Mehmet Asim Bilen
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Pp 52-57 (2022)
Introduction: There are three combination immune checkpoint inhibitor (ICI)–based regimens in the first-line setting for metastatic renal cell carcinoma (mRCC). Currently, there is limited real-world data for clinical outcomes and toxicity in mRCC
Externí odkaz:
https://doaj.org/article/3b523ccfbd2e4ae9ba07ac843f39a4e8
Autor:
Mert Boya, Tevhide Ozkaya-Ahmadov, Brandi E. Swain, Chia-Heng Chu, Norh Asmare, Ozgun Civelekoglu, Ruxiu Liu, Dohwan Lee, Sherry Tobia, Shweta Biliya, L. DeEtte McDonald, Bassel Nazha, Omer Kucuk, Martin G. Sanda, Benedict B. Benigno, Carlos S. Moreno, Mehmet A. Bilen, John F. McDonald, A. Fatih Sarioglu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Metastatic CTC clusters remain relatively unexplored due to the lack of optimized and practical technologies for their detection. Here the authors report Cluster-Wells to isolate CTC clusters in whole blood; they show this allows viable cluster retri
Externí odkaz:
https://doaj.org/article/5012ddfb6f8249cca14a1d80a809d054
Autor:
Rui Zhao, Xiaowei Ma, Lijuan Bai, Xin Li, Kenza Mamouni, Yang Yang, HongYan Liu, Alira Danaher, Nicholas Cook, Omer Kucuk, Robert S. Hodges, Lajos Gera, Daqing Wu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1261-1274 (2021)
A major challenge to the treatment of advanced prostate cancer (PCa) is the development of resistance to androgen-deprivation therapy (ADT) and chemotherapy. It is imperative to discover effective therapies to overcome drug resistance and improve cli
Externí odkaz:
https://doaj.org/article/1f6b060eb516456db0aa542c6160f224
Autor:
Tony Zibo Zhuang, Lara Harik, Seth Force, Agreen Hadadi, Mehmet Asim Bilen, Jacqueline T. Brown, Bradley C. Carthon, Jamie Goldman, Omer Kucuk, Viraj A. Master, Bassel Nazha
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The role of cytoreductive nephrectomy in patients with metastatic renal cell carcinoma is a subject of debate. We report a durable complete response in a 62-year-old man Jehovah’s Witness with metastatic clear cell renal cell carcinoma who received
Externí odkaz:
https://doaj.org/article/82d35e8cfd2f4bd2a107b982a151d13f
Autor:
Chia-Heng Chu, Ruxiu Liu, Tevhide Ozkaya-Ahmadov, Brandi E. Swain, Mert Boya, Bassel El-Rayes, Mehmet Akce, Mehmet Asim Bilen, Omer Kucuk, A. Fatih Sarioglu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Reliable and routine isolation of circulating tumor cells (CTCs) from peripheral blood would allow effective monitoring of the disease and guide the development of personalized treatments. Negative enrichment of CTCs by depleting normal bloo
Externí odkaz:
https://doaj.org/article/bb92eea29e384e16bec4919ebbcd628c
Autor:
Yuan Liu, Haydn Kissick, Viraj A Master, Mehmet A Bilen, Omer Kucuk, Bradley C Carthon, Nataliya Prokhnevska, Ewelina Sobierajska, Rachel Greenwald, Adeboye Osunkoya, Jennifer Wilkinson Carlisle, Caroline S Jansen, Maria Andrea Cardenas, Adriana Moon Reyes, Luke Del Balzo, Patrick Connor Mullane, Deborah Baumgarten, Fares Hosseinzadeh, Scott Wilkinson, Ross Lake, Adam G Sowalsky
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Purpose Checkpoint therapy is now the cornerstone of treatment for patients with renal cell carcinoma (RCC) with advanced disease, but biomarkers are lacking to predict which patients will benefit. This study proposes potential immunological biomarke
Externí odkaz:
https://doaj.org/article/7d09b80d31d542029330312b9c2f2744
Autor:
Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick, Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen, Wei Ping Qian, Lily Yang, Adeboye O. Osunkoya, Lawrence Boise, Paula M. Vertino, Yichao Zhao, Menglin Li, Hsiao-Rong Chen, Jeanne Kowalski, Omer Kucuk, Wei Zhou, Jin-Tang Dong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
The therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and r
Externí odkaz:
https://doaj.org/article/4767d9e2f20b432ab88e90cb4777af44
Autor:
James Robert Janopaul-Naylor, Jim Zhong, Yuan Liu, Chao Zhang, Adeboye O. Osunkoya, Shreyas Subhash Joshi, Mehmet Asim Bilen, Bradley Carthon, Omer Kucuk, Lindsey Marie Hartsell, Joseph Shelton, Ashesh B. Jani
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 26, Iss , Pp 30-34 (2021)
Purpose: For muscle-invasive bladder cancer, bladder preserving chemoradiotherapy (BPCRT) has shown to be a viable alternative for patients with urothelial carcinoma (UCa). Traditionally bladder cancer with variant histology UCa or other tumors types
Externí odkaz:
https://doaj.org/article/1e85af579fb94ecd921ae759aa66683e