Výsledky vyhledávání - "Omer Elmadbouh"

Protein kinase D: A therapeutic target in experimental alcoholic pancreatitis

Autor: Jingzhen Yuan, Chintan Chheda, Grace Tan, Omer Elmadbouh, Stephen J. Pandol

Publikováno v: Biochim Biophys Acta Mol Basis Dis

BACKGROUND: Alcohol abuse, a main cause of pancreatitis, has been known to augment NF-κB activation and cell necrosis in pancreatitis. However, the underlying mechanisms are unclear. We recently reported that inhibition of protein kinase D (PKD) all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5eb436dae000aa445af038704f33e80
https://pubmed.ncbi.nlm.nih.gov/35835415

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Trial in progress: A randomized phase II study of pembrolizumab with or without defactinib, a focal adhesion kinase inhibitor, following chemotherapy as a neoadjuvant and adjuvant treatment for resectable pancreatic ductal adenocarcinoma (PDAC)

Autor: John Davelaar, Zachariah Brown, Sheila Linden, Christina Rodriguez, Omer Elmadbouh, Jonathan A. Pachter, Jun Gong, Andrew Eugene Hendifar, Simon Lo, Srinivas Gaddam, Nicholas Nissen, Richard A. Burkhart, Lei Zheng, Arsen Osipov

Publikováno v: Journal of Clinical Oncology. 40:TPS4192-TPS4192

TPS4192 Background: PDAC is an aggressive cancer. It remains refractory to checkpoint inhibition because of its significant desmoplastic and immunosuppressive tumor microenvironment (TME). Focal adhesion kinase (FAK), a non-receptor tyrosine kinase,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0df21017bfc2b9cb21ff6d1b979016c3
https://doi.org/10.1200/jco.2022.40.16_suppl.tps4192

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Impact of site-specific metastases on survival outcomes in pancreatic adenocarcinoma (PDAC) patients: A national analysis

Autor: Nima Nikravesh, Gillian Gresham, Eric Anderson, Omer Elmadbouh, Shant Thomassian, Natalie Moshayedi, John Davelaar, Simon Lo, Srinivas Gaddam, Nicholas Nissen, Kambiz Kosari, Alexandra Gangi, Stephen Jacob Pandol, Jun Gong, Andrew Eugene Hendifar, Arsen Osipov

Publikováno v: Journal of Clinical Oncology. 40:e16270-e16270

e16270 Background: PDAC is the third most fatal cancer, where most patients present with metastases at diagnosis. Previous studies, including a retrospective analysis from our single-center experience, suggests survival rates are significantly higher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::648c88bee0c344be2d7e82595e774b33
https://doi.org/10.1200/jco.2022.40.16_suppl.e16270

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