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Akademický článek

Development of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF translation in synaptic-axonal genes

Autor: John E. Froberg, Omer Durak, Jeffrey D. Macklis

Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 112995- (2023)

Summary: Investigation of translation in rare cell types or subcellular contexts is challenging due to large input requirements for standard approaches. Here, we present “nanoRibo-seq” an optimized approach using 102- to 103-fold less input mater

Externí odkaz: https://doaj.org/article/42a16162a3e542219ca4125af0ae847e

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Akademický článek

Ascaroside expression in Caenorhabditis elegans is strongly dependent on diet and developmental stage.

Autor: Fatma Kaplan, Jagan Srinivasan, Parag Mahanti, Ramadan Ajredini, Omer Durak, Rathika Nimalendran, Paul W Sternberg, Peter E A Teal, Frank C Schroeder, Arthur S Edison, Hans T Alborn

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17804 (2011)

The ascarosides form a family of small molecules that have been isolated from cultures of the nematode Caenorhabditis elegans. They are often referred to as "dauer pheromones" because most of them induce formation of long-lived and highly stress resi

Externí odkaz: https://doaj.org/article/2acec5cfb67743e0806ffbc5a4444619

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Akademický článek

Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.

Autor: Ji-Song Guan, Susan C Su, Jun Gao, Nadine Joseph, Zhigang Xie, Ying Zhou, Omer Durak, Lei Zhang, J Julius Zhu, Karl R Clauser, Steven A Carr, Li-Huei Tsai

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25735 (2011)

Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been

Externí odkaz: https://doaj.org/article/a9249afcc62f468986aa4f3fac8e0457

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ASD gene Bcl11a regulates subcellular RNA localization, associative circuitry, and social behavior

Autor: Omer Durak, Ji-Yoon Kim, Dustin E. Tillman, Yasuhiro Itoh, Marit R. Wettstein, Luciano C. Greig, Thomas A. Addison, Jeffrey D. Macklis

Precise, area-specific connectivity of interhemispheric callosal projection neurons (CPN) in the cerebral cortex is critical for sensory, associative, and behavioral functions. CPN circuitry, which connects and integrates the cerebral hemispheres via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6243d77a810a54d42b67ba864cde75b3
https://doi.org/10.1101/2022.10.06.511159

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Development of Ultra-Low-Input nanoRibo-Seq Enables Quantification of Translational Control, Revealing Broad uORF Translation by Subtype-Specific Neurons

Autor: John E. Froberg, Omer Durak, Jeffrey D. Macklis

Publikováno v: SSRN Electronic Journal.

While increasingly powerful approaches enable investigation of transcription using small samples of RNA, approaches to investigate translational regulation in small populations of specific cell types, and/or (sub)-cellular contexts are lacking. Compr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d1bdd186257e506d6a996a8de88288
https://doi.org/10.2139/ssrn.4229514

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Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

Autor: Anthony J Martorell, Carol Y. Liu, L Ashley Watson, Fan Gao, Richard Rueda, Alexi Nott, Omer Durak, Yea Jin Kaeser-Woo, Li-Huei Tsai

Publikováno v: Nature neuroscience

De novo mutations in CHD8 are strongly associated with autism spectrum disorder (ASD), however the basic biology of CHD8 remains poor understood. Here we report that Chd8 knockdown during cortical development results in defective neural progenitor pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457aff7f52680533533472213bd22870
https://doi.org/10.1038/nn.4400

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Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt

Autor: Sihem Cheloufi, Kathi Zarnack, Christopher A. Walsh, Yang Shi, Elisabeth A. Murphy, Dinshaw J. Patel, Jernej Murn, Nicholas M. Luscombe, Li-Huei Tsai, Yawei J. Yang, Jernej Ule, Dilenny M. Gonzalez, Marianna Teplova, Omer Durak, Tomaž Curk, Johannes Zuber

Publikováno v: Genes & development, vol 29, iss 5
Cold Spring Harbor Laboratory Press

Cellular morphology is an essential determinant of cellular function in all kingdoms of life, yet little is known about how cell shape is controlled. Here we describe a molecular program that controls the early morphology of neurons through a metazoa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b952744ac06520f41f8f8882467146c1
https://doi.org/10.1101/gad.258483.115

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Cortical neurons gradually attain a post-mitotic state

Autor: Omer Durak, Ram Madabhushi, Birgit Schwanke, Melanie Richter, Li-Huei Tsai, Johannes Gräff, Froylan Calderon de Anda, Alison E. Mungenast, Jia Meng, Damien Rei, Konstantinos Meletis

Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly differentiated. However, neither the precise point at which this post-mitotic state is attained nor the extent of its irreversibility is clearly defined. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3119cf01776a28b69b0b5550fcabfbec
https://europepmc.org/articles/PMC5034108/

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