Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF

Autor: Aishwarya Omble, Shrutika Mahajan, Ashwini Bhoite, Kiran Kulkarni

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)

Abstract The Wnt-planar cell polarity (Wnt-PCP) pathway is crucial in establishing cell polarity during development and tissue homoeostasis. This pathway is found to be dysregulated in many pathological conditions, including cancer and autoimmune dis

Externí odkaz: https://doaj.org/article/f4f711312aeb4342b2f1419973be422e

In silico identification and characterization of the SNPs in the human ASTL gene and their probable role in female infertility

Autor: Kapali Suri, Neha Rajput, Priya Sharma, Aishwarya D. Omble, Kiran Kulkarni, Gagandeep K. Gahlay

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Ovastacin (ASTL), a zinc metalloprotease, is released from a fertilized egg during exocytosis of cortical granules which occurs minutes after the sperm and egg fuse. ASTL cleaves ZP2, one of the four primary glycoproteins of human zona pellucida, and

Externí odkaz: https://doaj.org/article/e5d4f968d06d46d7b63ab6a9b3c9fffa

GPCRs that Rhoar the Guanine nucleotide exchange factors

Autor: Kiran Kulkarni, Aishwarya Omble

Publikováno v: Small GTPases

Cell migration, a crucial step in numerous biological processes, is tightly regulated in space and time. Cells employ Rho GTPases, primarily Rho, Rac, and Cdc42, to regulate their motility. Like other small G proteins, Rho GTPases function as biomole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582f50d92959e5bb752a2dc996b4f5a6
https://doi.org/10.1080/21541248.2021.1896963

GPCRs that Rhoar the Guanine nucleotide exchange factors

Autor: Omble, Aishwarya, Kulkarni, Kiran

Publikováno v: Small GTPases; December 2022, Vol. 13 Issue: 1 p84-99, 16p

GPCRs that Rh oar the Guanine nucleotide exchange factors.

Autor: Omble A; Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Kulkarni K; Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.

Publikováno v: Small GTPases [Small GTPases] 2022 Jan; Vol. 13 (1), pp. 84-99. Date of Electronic Publication: 2021 Apr 14.