Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Omar S. Qureshi"'
Autor:
Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J. Hill, Aekkachai Tuekprakhon, Zhi Li, Cristina Matas de las Heras, Ana Teodosio, Andrea S. Lavado, Robert Moring, Ayesha Ashraf, Timothy R. Dafforn, Dimitris K. Grammatopoulos, John Gordon, Catherine A. Brady, Lawrence S. Young, Nicholas M. Barnes, Zania Stamataki, Omar S. Qureshi
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
IntroductionThe engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine e
Externí odkaz:
https://doaj.org/article/8359357ba2624784b5140879793cd87d
Autor:
Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTRozanolixizumab is a humanized anti-neonatal Fc receptor (FcRn) monoclonal antibody (mAb) of the immunoglobulin G4 (IgG4) sub-class, currently in clinical development for the treatment of IgG autoantibody-driven diseases. This format is frequ
Externí odkaz:
https://doaj.org/article/f74b0a47f067425f9e3ed7abc893041a
Autor:
Omar S. Qureshi, Hélène Bon, Breda Twomey, Gill Holdsworth, Kirsty Ford, Marianne Bergin, Linghong Huang, Mariusz Muzylak, Louise J. Healy, Vanessa Hurdowar, Timothy S. Johnson
Publikováno v:
Biology Open, Vol 6, Iss 10, Pp 1423-1433 (2017)
Activated fibroblasts are considered major drivers of fibrotic disease progression through the production of excessive extracellular matrix (ECM) in response to signals from damaged epithelial and inflammatory cells. Nevertheless, epithelial cells ar
Externí odkaz:
https://doaj.org/article/140c3a7051954b0289ee76090ca96b77
Autor:
Cayman Williams, Alan Kennedy, Shane Minogue, Neil Halliday, Erin Waters, David M. Sansom, Tie Zheng Hou, Behzad Rowshanravan, Daniel Janman, Claudia Hinze, Omar S. Qureshi
Publikováno v:
Immunology
CTLA‐4 is an essential regulator of T‐cell immune responses whose intracellular trafficking is a hallmark of its expression. Defects in CTLA‐4 trafficking due to LRBA deficiency cause profound autoimmunity in humans. CTLA‐4 rapidly internaliz
Autor:
Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J Hill, Cristina Matas de las Heras, Ana Teodosio, Andrea S Lavado, Timothy R Dafforn, Dimitris K Grammatopoulos, John Gordon, Catherine A Brady, Lawrence S Young, Nicholas M Barnes, Zania Stamataki, Omar S Qureshi
The engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells and accordingly blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine-elicited serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49fc2eadd7fcf70f0b9f3092b3d38880
https://doi.org/10.1101/2022.06.24.496409
https://doi.org/10.1101/2022.06.24.496409
Autor:
Dejian Xie, Gillian Grafton, Alexander Roberts, Nicholas A. Moore, Jinkun Huang, Nicholas M. Barnes, Catherine A. Brady, Kristian Brock, Shuang Liu, Andrew D. Powell, Zania Stamataki, Omar S. Qureshi, A.J Cooper, Chunlin Chen, Peter R. Guzzo, Sargent Bruce J, David D. Manning
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:122-134
The 5-hydroxytryptamine (5-HT) (serotonin) 5-HT3 receptor represents a clinical target for antagonists to deliver symptomatic relief to patients with diarrhea-predominant irritable bowel syndrome (IBS-d) or carcinoid syndrome. Unfortunately, this pha
Autor:
Zania Stamataki, Rebecca Rose, Emma Buckroyd, Stefan G. Hübscher, Scott P Davies, Maanav Leekha, Robin C. May, David H. Adams, Xiaoyan Li, Yuxin S. Liu, Nicholas M. Barnes, Ratnam Gandhi, Yuehua Huang, Alex L Wilkinson, Gary M. Reynolds, Joe Grove, Omar S. Qureshi
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1610-1620.e4 (2019)
Cell Reports
Cell Reports
Summary CD4+ T cells play critical roles in directing immunity, both as T helper and as regulatory T (Treg) cells. Here, we demonstrate that hepatocytes can modulate T cell populations through engulfment of live CD4+ lymphocytes. We term this phenome
Autor:
Rachel Upthegrove, Paulo Louzada-Junior, Fabiana Corsi-Zuelli, Omar S. Qureshi, Bill Deakin, Nicholas M. Barnes, Cristina Marta Del-Ben, Mikhael Haruo Fernandes de Lima
Publikováno v:
Brain, Behavior, & Immunity-Health
Brain, behavior, & immunity-health
Brain, Behavior, & Immunity-Health, Vol 17, Iss, Pp 100330-(2021)
Brain, behavior, & immunity-health
Brain, Behavior, & Immunity-Health, Vol 17, Iss, Pp 100330-(2021)
Many studies have reported that patients with psychosis, even before drug treatment, have mildly raised levels of blood cytokines relative to healthy controls. In contrast, there is a remarkable scarcity of studies investigating the cellular basis of
Autor:
Alan Kennedy, Erin Waters, Behzad Rowshanravan, Claudia Hinze, Cayman Williams, Daniel Janman, Thomas A. Fox, Claire Booth, Anne M. Pesenacker, Neil Halliday, Blagoje Soskic, Satdip Kaur, Omar S. Qureshi, Emma C. Morris, Shinji Ikemizu, Christopher Paluch, Jiandong Huo, Simon J. Davis, Emmanuel Boucrot, Lucy S. K. Walker, David M. Sansom
Publikováno v:
Nature immunology. 23(9)
CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity, balancing the activation and inhibition of T cell responses, respectively. Although both receptors share the same ligands, CD80 and CD86, the specific requirement for two dis
Autor:
Omar S. Qureshi, Fay Stewart, Andrew C Robinson, Charlotte Ferris, Nicholas M. Barnes, Zania Stamataki, Sebastian T Lugg, Aaron Scott, Tina Tang, Gerald Langman, Chiara Pallini, John R. Gordon, Thomas Pinkney, Alexander Roberts, Lindsay Bentley, David R Thickett, S. John Curnow, A.J Cooper, Graham S. Taylor, Kristian Brock, Bridget Hemming, Catherine A. Brady, Hollie Bancroft, Joanne Chapman, Babu Naidu, Joel Juvvanapudi, Graham R. Wallace
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are released from checkpoint inhibition to revive their inherent anti-tumour activity. Here we have studied various ways to