Výsledky vyhledávání - "Omar R. Alshykhly"

5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA Contexts

Autor: Omar R. Alshykhly, Aaron M. Fleming, Cynthia J. Burrows

Publikováno v: The Journal of Organic Chemistry

Exogenously and endogenously produced reactive oxygen species attack the base and sugar moieties of DNA showing a preference for reaction at 2'-deoxyguanosine (dG) sites. In the present work, dG was oxidized by HO(•) via the Fe(II)-Fenton reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ca002725f71cd39cb0c3619338d13e
https://doi.org/10.1021/acs.joc.5b00689

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Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin

Autor: Anita M. Orendt, Omar R. Alshykhly, Aaron M. Fleming, Cynthia J. Burrows

Publikováno v: Tetrahedron Letters. 56:3191-3196

Oxidation of the guanine heterocycle by two electrons can yield the chiral product 5-carboxamido-5-formamido-2-iminohydantoin (2Ih). The 2Ih free base enantiomers were synthesized from 2′-deoxyguanosine oxidized with a Cu(II)/H2O2 oxidant system fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f57116dd97377e4c61638ea1b14dd5
https://doi.org/10.1016/j.tetlet.2014.12.052

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Rates of Chemical Cleavage of DNA and RNA Oligomers Containing Guanine Oxidation Products

Autor: Omar R. Alshykhly, James G. Muller, Aaron M. Fleming, Cynthia J. Burrows, Judy Zhu

Publikováno v: Chemical Research in Toxicology

The nucleobase guanine in DNA (dG) and RNA (rG) has the lowest standard reduction potential of the bases, rendering it a major site of oxidative damage in these polymers. Mapping the sites at which oxidation occurs in an oligomer via chemical reagent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1208193b4ffb9380265f0357a728b694
http://europepmc.org/articles/PMC4482417

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Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair

Autor: Cynthia J. Burrows, Omar R. Alshykhly, Aaron M. Fleming

Publikováno v: Chemical research in toxicology. 28(9)

Guanine (G) is a target for oxidation by reactive oxygen species in DNA, RNA, and the nucleotide pool. Damage to DNA yields products with alternative properties toward DNA processing enzymes compared to those of the parent nucleotide. A new lesion, 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d6daab4ec6f25ad6f247fa4ec09690
https://pubmed.ncbi.nlm.nih.gov/26313343

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