Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Omar Quraishi"'
Autor:
Geneviève Nault, Sofiya A. Galkina, Omar Quraishi, Nathalie Bousquet-Gagnon, Dominique P. Bridon, Cheryl A. Stoddart
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:2162-2165
PC-1505 is a C34 peptide derived from the heptad repeat 2 region of HIV-1 gp41 conjugated to human serum albumin for sustained in vivo activity. One single preexposure dose of PC-1505 reduced viral RNA in HIV-1-infected SCID-hu Thy/Liv mice by 3.3 lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618ba11d158c16157af48784b8c5d9aa
https://doi.org/10.1128/aac.05015-11
https://doi.org/10.1128/aac.05015-11
Publikováno v:
Biochemistry. 50:6966-6972
HIV entry occurs by concerted conformational changes in the envelope protein complex on the surface of the virus. This complex is made up of a trimer of heterodimers of two subunits: surface subunit, gp120, and transmembrane subunit, gp41. Conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4706285bb56f998c871810d2b0e6f15d
https://doi.org/10.1021/bi201014b
https://doi.org/10.1021/bi201014b
Autor:
Nathalie Bousquet-Gagnon, Maryanne Bellomo, Marie K. Mankowski, Cheryl A. Stoddart, Véronique Paradis, Karen Thibaudeau, Geneviève Nault, Martin Robitaille, Sofiya A. Galkina, Patricia Liscourt, Dominique P. Bridon, Roger G. Ptak, Omar Quraishi, Marie-Ève Rivard, Peter Bakis, Alexandra Lobach
Publikováno v:
The Journal of Biological Chemistry
Entry inhibitors of human immunodeficiency virus, type 1 (HIV-1) have been the focus of much recent research. C34, a potent fusion inhibitor derived from the HR2 region of gp41, was engineered into a 1:1 human serum albumin conjugate through stable c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04acc6799ce809230d651fa04543e40b
https://doi.org/10.1074/jbc.m805536200
https://doi.org/10.1074/jbc.m805536200
Autor:
Robert Blumenthal, Nga Pham, Amy Jacobs, Geneviève Nault, Chantal Soucy, Martin Robitaille, Dominique P. Bridon, Xicai Huang, W. Gregory Alvord, Nathalie Bousquet-Gagnon, Omar Quraishi, Nicholas Francella
Publikováno v:
Journal of Biological Chemistry. 282:32406-32413
Peptide inhibitors corresponding to sequences in the six helix bundle structure of the fusogenic portion (gp41) of the HIV envelope glycoprotein have been successfully implemented in preventing HIV entry. These peptides bind to regions in HIV gp41 tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9881d6ed3aa66a367da71ba5f045e96
https://doi.org/10.1074/jbc.m705577200
https://doi.org/10.1074/jbc.m705577200
Autor:
Véronique Paradis, Martin Robitaille, Pieter van Wyk, Dominique P. Bridon, Karen Thibaudeau, Omar Quraishi, Jean-Paul Castaigne, Roger Leger, Xicai Huang, Chantal Soucy, Nathalie Bousquet-Gagnon
Publikováno v:
Bioconjugate Chemistry. 16:1000-1008
A series of human insulin maleimido derivatives with short and long linkers was synthesized by exploiting the variations in the pK(a) values and environment of the three amino groups present in the protein. The syntheses were accomplished in organic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a765e15f5b48404a316392ce84504b
https://doi.org/10.1021/bc050102k
https://doi.org/10.1021/bc050102k
Autor:
Corinne Benquet, Roger Leger, Dominique P. Bridon, Xicai Huang, Pieter van Wyk, Omar Quraishi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:841-845
Three peptide fragments of the kringle 5 region of plasminogen and their respective N- and C-terminus maleimido derivatives conjugated to Cys34 of human serum albumin were evaluated in vitro using a human umbilical vein endothelial cell (HUVEC) migra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a22eddf8313ff4f2b7e1048200b7c5d
https://doi.org/10.1016/j.bmcl.2003.12.025
https://doi.org/10.1016/j.bmcl.2003.12.025
Autor:
Pieter van Wyk, Jean-Paul Castaigne, Roger Leger, Omar Quraishi, Martin Robitaille, Corinne Benquet, Julie Carette, Elizabeth Denholm, Dominique P. Bridon, Nathalie Bousquet-Gagnon, Isabelle Pellerin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3571-3575
Atrial natriuretic peptide (ANP) is a clinically useful anti-hypertensive hormone. Maleimide derivatives of ANP have been synthesized and conjugated to cysteine-34 of human serum albumin. The conjugates were analyzed to assess their stability, recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdac221500a398a84c0394fe6e2a1eeb
https://doi.org/10.1016/s0960-894x(03)00790-x
https://doi.org/10.1016/s0960-894x(03)00790-x
Autor:
Omar Quraishi, Andrew C. Storer
Publikováno v:
Journal of Biological Chemistry. 276:8118-8124
The steps involved in the maturation of proenzymes belonging to the papain family of cysteine proteases have been difficult to characterize. Intermolecular processing at or near the pro/mature junction, due either to the catalytic activity of active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fd7c2eebf8f256a04c5c584e423d865
https://doi.org/10.1074/jbc.m005851200
https://doi.org/10.1074/jbc.m005851200
Autor:
Pieter van Wyk, Jean-Paul Castaigne, Nathalie Bousquet-Gagnon, Martin Robitaille, Dominique P. Bridon, Karen Thibaudeau, Julie Carette, Omar Quraishi, Roger Leger
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(17)
A series of analogs of GLP-1(7-36) amide containing a Nepsilon-(2-[2-[2-(3-maleimidopropylamido)ethoxy]ethoxy]acetyl)lysine has been synthesized and the resulting derivatives were bioconjugated to Cys34 of human serum albumin (HSA). The GLP-1-HSA bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513c1fcada07dfcf6e7584a07d6cc5e4
https://pubmed.ncbi.nlm.nih.gov/15357960
https://pubmed.ncbi.nlm.nih.gov/15357960
Autor:
Ted Fox, John S. Mort, Andrew C. Storer, Omar Quraishi, Dorit K. Nägler, Miroslaw Cygler, J. Sivaraman
Publikováno v:
Biochemistry. 38(16)
Papain-like proenzymes are prone to autoprocess under acidic pH conditions. Similarly, peptides derived from the proregion of cathepsin B are potent pH-dependent inhibitors of that enzyme; i.e., at pH 6.0 the inhibition of human cathepsin B by its pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d7c59e00157c1dc34572431bf79d67
https://pubmed.ncbi.nlm.nih.gov/10213604
https://pubmed.ncbi.nlm.nih.gov/10213604