Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Omar Mossad"'
Autor:
Marius Schwabenland, Omar Mossad, Annika Sievert, Adam G. Peres, Elena Ringel, Sebastian Baasch, Julia Kolter, Giulia Cascone, Nikolaos Dokalis, Andreas Vlachos, Zsolt Ruzsics, Philipp Henneke, Marco Prinz, Thomas Blank
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract While the precise processes underlying a sex bias in the development of central nervous system (CNS) disorders are unknown, there is growing evidence that an early life immune activation can contribute to the disease pathogenesis. When we mi
Externí odkaz:
https://doaj.org/article/022f19c530b44fd49b9880275f4ac107
Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia
Autor:
Jannis Wißfeld, Mona Mathews, Omar Mossad, Paola Picardi, Alessandro Cinti, Loredana Redaelli, Laurent Pradier, Oliver Brüstle, Harald Neumann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract CD33/Sialic acid-binding Ig-like lectin 3 (SIGLEC3) is an innate immune receptor expressed on myeloid cells and mediates inhibitory signaling via tyrosine phosphatases. Variants of CD33 are associated with Alzheimer’s disease (AD) suggesti
Externí odkaz:
https://doaj.org/article/19d23649beca49f89cee8a4250b51988
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101186- (2022)
Summary: Most of the protocols to analyze metabolic features of cell populations from different tissues rely on in vitro cell culture conditions. Here, we present a flow-cytometry-based protocol for measuring the respiratory chain function in permeab
Externí odkaz:
https://doaj.org/article/d0b87f3e9c524096b0d70641b46c3bac
Autor:
Charlotte Mezö, Nikolaos Dokalis, Omar Mossad, Ori Staszewski, Jana Neuber, Bahtiyar Yilmaz, Daniel Schnepf, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg, Andrew J. Macpherson, Melanie Meyer-Luehmann, Peter Staeheli, Thomas Blank, Marco Prinz, Daniel Erny
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract It was recently revealed that gut microbiota promote amyloid-beta (Aβ) burden in mouse models of Alzheimer’s disease (AD). However, the underlying mechanisms when using either germ-free (GF) housing conditions or treatments with antibioti
Externí odkaz:
https://doaj.org/article/1ef4ef2c7b524187aa55817e1899a3d0
Autor:
Omar Mossad, Thomas Blank
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
The immune system is crucial for defending against various invaders, such as pathogens, cancer cells or misfolded proteins. With increasing age, the diminishing immune response, known as immunosenescence, becomes evident. Concomitantly, some diseases
Externí odkaz:
https://doaj.org/article/c4328b2e453b4ace8ad97396798119b1
Autor:
Marius Schwabenland, Omar Mossad, Adam G. Peres, Franziska Kessler, Feres Jose Mocayar Maron, Laura-Adela Harsan, Thomas Bienert, Dominik von Elverfeldt, Klaus-Peter Knobeloch, Ori Staszewski, Frank L. Heppner, Marije E. C. Meuwissen, Grazia M. S. Mancini, Marco Prinz, Thomas Blank
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-6 (2019)
Externí odkaz:
https://doaj.org/article/236b33d0bdba497fb77c847152b3950b
Autor:
Omar Mossad, Bérénice Batut, Bahtiyar Yilmaz, Nikolaos Dokalis, Charlotte Mezö, Elisa Nent, Lara Susann Nabavi, Melanie Mayer, Feres José Mocayar Maron, Joerg M. Buescher, Mercedes Gomez de Agüero, Antal Szalay, Tim Lämmermann, Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg, Rolf Backofen, Daniel Erny, Marco Prinz, Thomas Blank
Publikováno v:
Nature Neuroscience
Microglial function declines during aging. The interaction of microglia with the gut microbiota has been well characterized during development and adulthood but not in aging. Here, we compared microglial transcriptomes from young-adult and aged mice
Autor:
Omar Mossad, Elisa Nent, Sabrina Woltemate, Shani Folschweiller, Joerg M. Buescher, Daniel Schnepf, Daniel Erny, Peter Staeheli, Marlene Bartos, Antal Szalay, Bärbel Stecher, Marius Vital, Jonas F. Sauer, Tim Lämmermann, Marco Prinz, Thomas Blank
Publikováno v:
Nature aging
Understanding the physiological origins of age-related cognitive decline is of critical importance given the rising age of the world’s population. Previous work in animal models has established a strong link between cognitive performance and the mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ea1f298d870ede1271332f31782319
https://hdl.handle.net/21.11116/0000-000A-17E2-D21.11116/0000-000A-17E4-B
https://hdl.handle.net/21.11116/0000-000A-17E2-D21.11116/0000-000A-17E4-B
Publikováno v:
ACM Multimedia
Cloud gaming enables users to play games on virtually any device. This is achieved by offloading the game rendering and encoding to cloud datacenters. As game resolutions and frame rates increase, cloud gaming platforms face a major challenge to stre
Publikováno v:
Neuroforum. 25:205-212
Summary Microbiome research has grown significantly in the last decade, highlighting manifold implications of the microbiota to the host’s health. The gut microbiota is connected to the brain through several avenues that allow their interaction. Th