Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Omar M. Lopez"'
Autor:
Jianguo Huang, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, David Van Mater, William C. Eward, Diana M. Cardona, Lixia Luo, Yan Ma, Omar M. Lopez, Christopher E. Nelson, Jacqueline N. Robinson-Hamm, Anupama Reddy, Sandeep S. Dave, Charles A. Gersbach, Rebecca D. Dodd, David G. Kirsch
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Site-specific recombination and CRISPR-Cas9 have been used to generate genetically engineered mouse models of cancer. Here the authors compare sarcomas generated using both systems and see similar genetic and cellular phenotypes, suggesting CRISPR-Ca
Externí odkaz:
https://doaj.org/article/43b8c0058e5a4216b4fb7dadf1a3b419
Autor:
Omar M. Lopez, Michelle Zhang, Peter G. Hendrickson, Jianguo Huang, Andrea R. Daniel, Jane Blackmer, Lixia Luo, Laura D. Attardi, David Corcoran, David G. Kirsch
Accumulating data suggest that the long interspersed nuclear element 1 (LINE1), a major class of transposable elements, can promote tumorigenesis by causing deletions of tumor suppressor genes, amplifications of oncogenes, and chromosomal translocati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b037ceb1c89fa451edfabb86aa8420c
https://doi.org/10.1101/2023.02.06.527304
https://doi.org/10.1101/2023.02.06.527304
Autor:
Moiez Ali, Min Lu, Hazel Xiaohui Ang, Ryan S. Soderquist, Christine E. Eyler, Haley M. Hutchinson, Carolyn Glass, Christopher F. Bassil, Omar M. Lopez, D. Lucas Kerr, Christina J. Falcon, Helena A. Yu, Aaron N. Hata, Collin M. Blakely, Caroline E. McCoach, Trever G. Bivona, Kris C. Wood
Publikováno v:
Science translational medicine, vol 14, iss 638
Residual cancer cells that survive drug treatments with targeted therapies act as a reservoir from which eventual resistant disease emerges. Although there is great interest in therapeutically targeting residual cells, efforts are hampered by our lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87301bafcf92eb5ae24f348c85cd184
https://pubmed.ncbi.nlm.nih.gov/35353542
https://pubmed.ncbi.nlm.nih.gov/35353542
Autor:
Lisa D. Cervia, Nerissa Williams, Tomoyo Okada, Jianguo Huang, Timothy J. Robinson, Alexander J. Lazar, Nalan Gokgoz, Yan Ma, Samuel Singer, Krista Pipho, Jay S. Wunder, Stephano S. Mello, David G. Kirsch, Andrew Seto, Xiaodi Qin, Kouros Owzar, Omar M. Lopez, Mohit Sachdeva, Eric S. Xu, Lixia Luo, Fan Yuan, Jimena Giudice, Irene L. Andrulis, Dadong Zhang, Brian P. Rubin
Publikováno v:
Mol Cancer Res
Soft-tissue sarcomas (STS) are rare malignancies showing lineage differentiation toward diverse mesenchymal tissues. Half of all high-grade STSs develop lung metastasis with a median survival of 15 months. Here, we used a genetically engineered mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6005d9c55f889e635869dd44d18ef949
https://doi.org/10.1158/1541-7786.mcr-19-1170
https://doi.org/10.1158/1541-7786.mcr-19-1170
Autor:
Yvonne M. Mowery, Charles A. Gersbach, Hsuan-Cheng Kuo, Jianguo Huang, Melodi Javid Whitley, Diana M. Cardona, Yan Ma, Rebecca D. Dodd, David G. Kirsch, Sandeep S. Dave, Lixia Luo, Mark Chen, David Van Mater, Christopher E. Nelson, Jacqueline N. Robinson-Hamm, Andrea Walens, William C. Eward, Omar M. Lopez, Eric S. Xu, Anupama Reddy
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
Genetically engineered mouse models that employ site-specific recombinase technology are important tools for cancer research but can be costly and time-consuming. The CRISPR-Cas9 system has been adapted to generate autochthonous tumours in mice, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1216806ecf1a31b3c7b71969007d9d05
https://doi.org/10.1038/ncomms15999
https://doi.org/10.1038/ncomms15999
Autor:
Charles A. Gersbach, Andrea Walens, Sandeep S. Dave, Diana M. Cardona, Anupama Reddy, Lixia Luo, Hsuan-Cheng Kuo, David Van Mater, David G. Kirsch, Jianguo Huang, Yvonne M. Mowery, Yan Ma, Christopher E. Nelson, William C. Eward, Jacqueline N. Robinson-Hamm, Eric S. Xu, Melodi Javid Whitley, Rebecca D. Dodd, Omar M. Lopez, Mark Chen
Publikováno v:
Clinical Cancer Research. 24:A17-A17
Genetically engineered mouse models (GEMMs) that employ site-specific recombinase (SSR) technology are important tools for cancer research, and recently the CRISPR/Cas9 system has been increasingly utilized to model cancer in mice. Here, we used CRIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7902ad62658e49861cdfe0d175ca58b0
https://doi.org/10.1158/1557-3265.sarcomas17-a17
https://doi.org/10.1158/1557-3265.sarcomas17-a17
Autor:
Omar M. Lopez, Tao Sun, Handan Xiang, Haiyang Wu, Lifeng Yuan, Rui Chen, Calvin Lau, Ying Wan, Mengyang Chong, Qi-Jing Li, Si-Qi Liu, Peter B. Alexander, Xiao-Fan Wang, Xia Gao, Scott H. Randell, Yi Ding
Publikováno v:
Cell Discovery
Cellular senescence is a cell fate characterized by an irreversible cell cycle arrest, but the molecular mechanism underlying this senescence hallmark remains poorly understood. Through an unbiased search for novel senescence regulators in airway bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583b79e2a226c599b1b35abc440aa20c
http://europepmc.org/articles/PMC5468773
http://europepmc.org/articles/PMC5468773