Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Omar M. El Agnaf"'
Autor:
Frank Schmidt, Houari B. Abdesselem, Karsten Suhre, Nishant N. Vaikath, Muhammad U. Sohail, Maryam Al-Nesf, Ilham Bensmail, Fathima Mashod, Hina Sarwath, Joerg Bernhardt, Stephanie Schaefer-Ramadan, Ti-Myen Tan, Priscilla E. Morris, Edward J. Schenck, David Price, Vidya Mohamed-Ali, Mohammed Al-Maadheed, Abdelilah Arredouani, Julie Decock, Jonathan M. Blackburn, Augustine M. K. Choi, Omar M. El-Agnaf
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: Coronavirus disease (COVID-19) manifests many clinical symptoms, including an exacerbated immune response and cytokine storm. Autoantibodies in COVID-19 may have severe prodromal effects that are poorly understood. The interaction between
Externí odkaz:
https://doaj.org/article/cafc2cc0758a400281587d6a1c37112f
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105995- (2023)
Externí odkaz:
https://doaj.org/article/77154b48e00b4c3d8c96864a3e8ae055
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105771- (2022)
Despite the increasing number of studies on Parkinson's disease and it being the second most common neurodegenerative disorder in the world, no established diagnostic markers or disease modifying therapies are available. Understanding the mechanisms
Externí odkaz:
https://doaj.org/article/b8a8c9e0cc10421a860d41d07ba8f3ed
Autor:
Jia-Zhen Wu, Mustafa Ardah, Caroline Haikal, Alexander Svanbergsson, Meike Diepenbroek, Nishant N. Vaikath, Wen Li, Zhan-You Wang, Tiago F. Outeiro, Omar M. El-Agnaf, Jia-Yi Li
Publikováno v:
Translational Neurodegeneration, Vol 8, Iss 1, Pp 1-15 (2019)
Abstract Background Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggregation in vitro and
Externí odkaz:
https://doaj.org/article/5804e97c94bb42328dfc122517329af0
Autor:
Ilham Y. Abdi, Nour K. Majbour, Eline A. J. Willemse, Wilma D. J. van de Berg, Brit Mollenhauer, Charlotte E. Teunissen, Omar M. El-Agnaf
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Background: The role of cerebrospinal fluid (CSF) alpha-synuclein as a potential biomarker has been challenged mainly due to variable preanalytical measures between laboratories. To evaluate the impact of the preanalytical factors contributing to suc
Externí odkaz:
https://doaj.org/article/3cc31443f7a74e0e8788d872e5a3f6b3
Autor:
Vasilios C. Constantinides, Nour K. Majbour, George P. Paraskevas, Ilham Abdi, Bared Safieh-Garabedian, Leonidas Stefanis, Omar M. El-Agnaf, Elisabeth Kapaki
Publikováno v:
Brain Sciences, Vol 11, Iss 1, p 119 (2021)
Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the differentiation from healthy c
Externí odkaz:
https://doaj.org/article/4396313e273e421abe39316303642ebb
Autor:
Frank Schmidt, Houari B. Abdesselem, Karsten Suhre, Muhammad U. Sohail, Maryam Al-Nesf, Ilham Bensmail, Fathima Mashod, Hina Sarwath, Joerg Bernhardt, Ti-Myen Tan, Priscilla E Morris, Edward J. Schenck, David Price, Nishant N. Vaikath, Vidya Mohamed-Ali, Mohammed Al-Maadheed, Abdelilah Arredouani, Julie Decock, Jonathan M. Blackburn, Augustine M.K. Choi, Omar M. El-Agnaf
The role of autoantibodies in coronavirus disease (COVID-19) complications is not yet fully understood. The current investigation screened two independent cohorts of 97 COVID-19 patients (Discovery (Disc) cohort from Qatar (n = 49) and Replication (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::019e80d3a4d86295b37a8414c3a2786c
https://doi.org/10.1101/2022.02.09.479669
https://doi.org/10.1101/2022.02.09.479669
Autor:
Niels Kruse, Michael G Schlossmacher, Walter J Schulz-Schaeffer, Eugeen Vanmechelen, Hugo Vanderstichele, Omar M El-Agnaf, Brit Mollenhauer
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153564 (2016)
The quantification of four distinct proteins (α-synuclein, β-amyloid1-42, DJ-1, and total tau) in cerebrospinal fluid (CSF) has been proposed as a laboratory-based platform for the diagnosis of Parkinson's disease (PD) and Alzheimer's disease (AD).
Externí odkaz:
https://doaj.org/article/5cfaf20ec15144fa9c5af133de06885b
Autor:
Henrik Zetterberg, Dominic M. Walsh, Aleksey Lomakin, Johan Svensson, Timothy Lynch, Omar M. El Agnaf, Mustafa T. Ardah, Per Johansson, Seán O'Dowd, Kinley Roberts, Gemma Cummins, George B. Benedek
Publikováno v:
Journal of Alzheimer's Disease. 33:923-928
Elevated cerebrospinal fluid concentrations of tau discriminate Alzheimer's disease from other neurodegenerative conditions. The reasons for this are unclear. While commercial assay kits are widely used to determine total-tau concentrations, little i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61865f7a2e429b183cf5b66429c9d074
https://doi.org/10.3233/jad-2012-121393
https://doi.org/10.3233/jad-2012-121393
Autor:
Aroldo Rossi, Paolo Calabresi, Silvia Paciotti, Nicola Tambasco, Lucilla Parnetti, Paolo Eusebi, Emanuele Persichetti, Michela Codini, Davide Chiasserini, Omar M. El. Agnaf, Tommaso Beccari, Claudia De Carlo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 7, p e101453 (2014)
PLoS ONE, Vol 9, Iss 7, p e101453 (2014)
Measurements of the activities of lysosomal enzymes in cerebrospinal fluid have recently been proposed as putative biomarkers for Parkinson's disease and other synucleinopathies. To define the operating procedures useful for ensuring the reliability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31cb26fe21a237361261fe9fd76af5b
http://hdl.handle.net/11391/1284097
http://hdl.handle.net/11391/1284097