Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus

Autor: Asma A Elashi, Salman M Toor, Umm-Kulthum Ismail Umlai, Yasser A Al-Sarraj, Shahrad Taheri, Karsten Suhre, Abdul Badi Abou-Samra, Omar M E Albagha

Publikováno v: BMC Medical Genomics, Vol 17, Iss 1, Pp 1-12 (2024)

Abstract Background The genetic basis of type 2 diabetes (T2D) is under-investigated in the Middle East, despite the rapidly growing disease prevalence. We aimed to define the genetic determinants of T2D in Qatar. Methods Using whole genome sequencin

Externí odkaz: https://doaj.org/article/c774abd0646240a2b405daad8348f9b2

Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population

Autor: Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Abdul Badi Abou‑Samra, Karsten Suhre

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Four T2D subtypes were previously identified: severe insulin deficient, severe insulin resistant, mild obesity-related, and mild age-related diabetes. Here, the authors show that these subtypes can be translated to an Arabic population and identify d

Externí odkaz: https://doaj.org/article/024c4ed8cecf48589549684338878032

The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects

Autor: Ilhame Diboun, Yasser Al-Sarraj, Salman M. Toor, Shaban Mohammed, Nadeem Qureshi, Moza S. H. Al Hail, Amin Jayyousi, Jassim Al Suwaidi, Omar M. E. Albagha

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Familial hypercholesterolemia (FH) is an inherited disease characterized by reduced efficiency of low-density lipoprotein-cholesterol (LDL-C) removal from the blood and, consequently, an increased risk of life-threatening early cardiovascular complic

Externí odkaz: https://doaj.org/article/24e107776a2c4f2a8e333ab37ad49833

Comprehensive Transcriptomic Profiling of Murine Osteoclast Differentiation Reveals Novel Differentially Expressed Genes and LncRNAs

Autor: Salman M. Toor, Sachin Wani, Omar M. E. Albagha

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Osteoclasts are the sole bone resorbing cells, which undertake opposing roles to osteoblasts to affect skeletal mass and structure. However, unraveling the comprehensive molecular mechanisms behind osteoclast differentiation is necessitated to overco

Externí odkaz: https://doaj.org/article/e0add5643ad847dbb150bad583507793

Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy

Autor: Nerea Alonso, Omar M E Albagha, Asim Azfer, Beatriz Larraz-Prieto, Kathryn Berg, Philip L Riches, Barbara Ostanek, Tomaz Kocjan, Janja Marc, Bente L Langdahl, Stuart H Ralston

Publikováno v: Alonso, N, Albagha, O M E, Azfer, A, Larraz-Prieto, B, Berg, K, Riches, P L, Ostanek, B, Kocjan, T, Marc, J, Langdahl, B L & Ralston, S H 2023, ' Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy ', Annals of the Rheumatic Diseases, vol. 82, no. 7, pp. 985-991 . https://doi.org/10.1136/ard-2022-223618

ObjectivesTeriparatide (TPTD) is an effective treatment for osteoporosis but the individual response to therapy is variable for reasons that are unclear. This study aimed to determine whether the response to TPTD might be influenced by genetic factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1049742e9ffdbf5491e6317da0fc9d
https://pure.au.dk/portal/da/publications/genomewide-association-study-identifies-genetic-variants-which-predict-the-response-of-bone-mineral-density-to-teriparatide-therapy(34e42bcd-5709-40ce-8190-7b1b6ac2ad79).html