Výsledky vyhledávání - "Omar L. Francone"

Akademický článek

Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH

Autor: Seemin S. Ahmed, Hillard Rubin, Minglun Wang, Deiby Faulkner, Arnold Sengooba, Serena N. Dollive, Nancy Avila, Jeff L. Ellsworth, Diana Lamppu, Maria Lobikin, Jason Lotterhand, Laura Adamson-Small, Teresa Wright, Albert Seymour, Omar L. Francone

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 568-580 (2020)

Phenylketonuria is an inborn error of metabolism caused by loss of function of the liver-expressed enzyme phenylalanine hydroxylase and is characterized by elevated systemic phenylalanine levels that are neurotoxic. Current therapies do not address t

Externí odkaz: https://doaj.org/article/b01d454355934bc48f5e9e66ef3b1092

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Akademický článek

Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression[S]

Autor: Wanida Ruangsiriluk, Shaun E. Grosskurth, Daniel Ziemek, Max Kuhn, Shelley G. des Etages, Omar L. Francone

Publikováno v: Journal of Lipid Research, Vol 53, Iss 8, Pp 1459-1471 (2012)

Dysregulation of ceramide synthesis has been associated with metabolic disorders such as atherosclerosis and diabetes. We examined the changes in lipid homeostasis and gene expression in Huh7 hepatocytes when the synthesis of ceramide is perturbed by

Externí odkaz: https://doaj.org/article/43d09733156841e98dea15d49809a06f

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Akademický článek

Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels

Autor: Omar L. Francone, Brian Y. Ishida, Margarita de la Llera-Moya, Lori Royer, Christiane Happe, Jian Zhu, Robert J. Chalkey, Peter Schaefer, Cheryl Cox, Al Burlingame, John P. Kane, George H. Rothblat

Publikováno v: Journal of Lipid Research, Vol 52, Iss 11, Pp 1974-1983 (2011)

Given the increased prevalence of cardiovascular disease in the world, the search for genetic variations that impact risk factors associated with the development of this disease continues. Multiple genetic association studies demonstrate that procoll

Externí odkaz: https://doaj.org/article/41e1133ed2ab4ba59e70694a3664f103

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Akademický článek

Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection[S]

Autor: Ronald W. Clark, David Cunningham, Yang Cong, Timothy A. Subashi, George T. Tkalcevic, David B. Lloyd, James G. Boyd, Boris A. Chrunyk, George A. Karam, Xiayang Qiu, Ing-Kae Wang, Omar L. Francone

Publikováno v: Journal of Lipid Research, Vol 51, Iss 5, Pp 967-974 (2010)

The CETP inhibitor, torcetrapib, was prematurely terminated from phase 3 clinical trials due to an increase in cardiovascular and noncardiovascular mortality. Because nearly half of the latter deaths involved patients with infection, we have tested t

Externí odkaz: https://doaj.org/article/90ebce87c8a64100a15f3130a1645823

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Akademický článek

Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1

Autor: Jian Zhu, Joseph Gardner, Clive R. Pullinger, John P. Kane, John F. Thompson, Omar L. Francone

Publikováno v: Journal of Lipid Research, Vol 50, Iss 7, Pp 1330-1339 (2009)

Given the increased prevalence of cardiovascular disease in the world, the search for genetic variations controlling the levels of risk factors associated with the development of the disease continues. Multiple genetic association studies suggest the

Externí odkaz: https://doaj.org/article/548e903b0a1a4bcb845cfa9932f88abf

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Akademický článek

The hydrophobic tunnel present in LOX-1 is essential for oxidized LDL recognition and binding

Autor: Omar L. Francone, Meihua Tu, Lori J. Royer, Jian Zhu, Kimberly Stevens, Joseph J. Oleynek, Zhiwu Lin, Lorraine Shelley, Thomas Sand, Yi Luo, Christopher D. Kane

Publikováno v: Journal of Lipid Research, Vol 50, Iss 3, Pp 546-555 (2009)

Lectin-like oxidized LDL (ox-LDL) receptor-1 (LOX-1) is a type-II transmembrane protein that belongs to the C-type lectin family of molecules. LOX-1 acts as a cell surface endocytosis receptor and mediates the recognition and internalization of ox-LD

Externí odkaz: https://doaj.org/article/15d6239d33c843fdaad050cff75c573f

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Akademický článek

Remodeling of HDL by CETP in vivo and by CETP and hepatic lipase in vitro results in enhanced uptake of HDL CE by cells expressing scavenger receptor B-I

Autor: Xavier Collet, Alan R. Tall, Humaira Serajuddin, Karim Guendouzi, Lori Royer, Helena Oliveira, Ronald Barbaras, Xian-cheng Jiang, Omar L. Francone

Publikováno v: Journal of Lipid Research, Vol 40, Iss 7, Pp 1185-1193 (1999)

The transport of HDL cholesteryl esters (CE) from plasma to the liver involves a direct uptake pathway, mediated by hepatic scavenger receptor B-I (SR-BI), and an indirect pathway, involving the exchange of HDL CE for triglycerides (TG) of TG-rich li

Externí odkaz: https://doaj.org/article/06b27edf023a4abd9bd3176ee1f8d074

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Akademický článek

Binding and functional effects of transcription factors Sp1 and Sp3 on the proximal human lecithin:cholesterol acyltransferase promoter

Autor: Kenneth L. Hoppe, Omar L. Francone

Publikováno v: Journal of Lipid Research, Vol 39, Iss 5, Pp 969-977 (1998)

Human lecithin:cholesterol acyltransferase (LCAT) circulates in plasma bound to high density lipoproteins (HDL) and modulates the rate by which cholesteryl ester is transported to the liver. So far, little is known about the regulation of the express

Externí odkaz: https://doaj.org/article/4e54532f64164e78b43c77ec00811a5e

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