Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Omar L Francone"'
Autor:
Laura J. Smith, Lindsay A. Schulman, Samantha Smith, Laura Van Lieshout, Carmen M. Barnes, Liana Behmoiras, Meghan Scarpitti, Monicah Kivaa, Khanh L. Duong, Ludo O. Benard, Jeff L. Ellsworth, Nancy Avila, Deiby Faulkner, April Hayes, Jason Lotterhand, Jose Israel Rivas, Arnold V. Sengooba, Alec Tzianabos, Albert B. Seymour, Omar L. Francone
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 224-238 (2022)
Adeno-associated viruses derived from human hematopoietic stem cells (AAVHSCs) are naturally occurring AAVs. Fifteen AAVHSCs have demonstrated broad biodistribution while displaying differences in transduction. We examine the structure-function relat
Externí odkaz:
https://doaj.org/article/7732422524634ae684ab6a55ab50be2f
Autor:
Seemin S. Ahmed, Hillard Rubin, Minglun Wang, Deiby Faulkner, Arnold Sengooba, Serena N. Dollive, Nancy Avila, Jeff L. Ellsworth, Diana Lamppu, Maria Lobikin, Jason Lotterhand, Laura Adamson-Small, Teresa Wright, Albert Seymour, Omar L. Francone
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 568-580 (2020)
Phenylketonuria is an inborn error of metabolism caused by loss of function of the liver-expressed enzyme phenylalanine hydroxylase and is characterized by elevated systemic phenylalanine levels that are neurotoxic. Current therapies do not address t
Externí odkaz:
https://doaj.org/article/b01d454355934bc48f5e9e66ef3b1092
Autor:
Thia St. Martin, Tania A. Seabrook, Katherine Gall, Jenn Newman, Nancy Avila, April Hayes, Monicah Kivaa, Jason Lotterhand, Michael Mercaldi, Kruti Patel, Israel J. Rivas, Stephen Woodcock, Teresa L. Wright, Albert B. Seymour, Omar L. Francone, Jacinthe Gingras
Publikováno v:
The Journal of Neuroscience. 43:3567-3581
Metachromatic leukodystrophy (MLD) is a rare, inherited, demyelinating lysosomal storage disorder caused by mutations in the arylsulfatase-A gene (ARSA). In patients, levels of functional ARSA enzyme are diminished and lead to deleterious accumulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9909135154d181ef490aed2f819663ee
https://doi.org/10.1523/jneurosci.1829-22.2023
https://doi.org/10.1523/jneurosci.1829-22.2023
Autor:
Wanida Ruangsiriluk, Shaun E. Grosskurth, Daniel Ziemek, Max Kuhn, Shelley G. des Etages, Omar L. Francone
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 8, Pp 1459-1471 (2012)
Dysregulation of ceramide synthesis has been associated with metabolic disorders such as atherosclerosis and diabetes. We examined the changes in lipid homeostasis and gene expression in Huh7 hepatocytes when the synthesis of ceramide is perturbed by
Externí odkaz:
https://doaj.org/article/43d09733156841e98dea15d49809a06f
Autor:
Omar L. Francone, Brian Y. Ishida, Margarita de la Llera-Moya, Lori Royer, Christiane Happe, Jian Zhu, Robert J. Chalkey, Peter Schaefer, Cheryl Cox, Al Burlingame, John P. Kane, George H. Rothblat
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 1974-1983 (2011)
Given the increased prevalence of cardiovascular disease in the world, the search for genetic variations that impact risk factors associated with the development of this disease continues. Multiple genetic association studies demonstrate that procoll
Externí odkaz:
https://doaj.org/article/41e1133ed2ab4ba59e70694a3664f103
Autor:
Ronald W. Clark, David Cunningham, Yang Cong, Timothy A. Subashi, George T. Tkalcevic, David B. Lloyd, James G. Boyd, Boris A. Chrunyk, George A. Karam, Xiayang Qiu, Ing-Kae Wang, Omar L. Francone
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 967-974 (2010)
The CETP inhibitor, torcetrapib, was prematurely terminated from phase 3 clinical trials due to an increase in cardiovascular and noncardiovascular mortality. Because nearly half of the latter deaths involved patients with infection, we have tested t
Externí odkaz:
https://doaj.org/article/90ebce87c8a64100a15f3130a1645823
Autor:
Jian Zhu, Joseph Gardner, Clive R. Pullinger, John P. Kane, John F. Thompson, Omar L. Francone
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 7, Pp 1330-1339 (2009)
Given the increased prevalence of cardiovascular disease in the world, the search for genetic variations controlling the levels of risk factors associated with the development of the disease continues. Multiple genetic association studies suggest the
Externí odkaz:
https://doaj.org/article/548e903b0a1a4bcb845cfa9932f88abf
Autor:
Omar L. Francone, Meihua Tu, Lori J. Royer, Jian Zhu, Kimberly Stevens, Joseph J. Oleynek, Zhiwu Lin, Lorraine Shelley, Thomas Sand, Yi Luo, Christopher D. Kane
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 546-555 (2009)
Lectin-like oxidized LDL (ox-LDL) receptor-1 (LOX-1) is a type-II transmembrane protein that belongs to the C-type lectin family of molecules. LOX-1 acts as a cell surface endocytosis receptor and mediates the recognition and internalization of ox-LD
Externí odkaz:
https://doaj.org/article/15d6239d33c843fdaad050cff75c573f
Autor:
Xavier Collet, Alan R. Tall, Humaira Serajuddin, Karim Guendouzi, Lori Royer, Helena Oliveira, Ronald Barbaras, Xian-cheng Jiang, Omar L. Francone
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 7, Pp 1185-1193 (1999)
The transport of HDL cholesteryl esters (CE) from plasma to the liver involves a direct uptake pathway, mediated by hepatic scavenger receptor B-I (SR-BI), and an indirect pathway, involving the exchange of HDL CE for triglycerides (TG) of TG-rich li
Externí odkaz:
https://doaj.org/article/06b27edf023a4abd9bd3176ee1f8d074
Autor:
Kenneth L. Hoppe, Omar L. Francone
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 5, Pp 969-977 (1998)
Human lecithin:cholesterol acyltransferase (LCAT) circulates in plasma bound to high density lipoproteins (HDL) and modulates the rate by which cholesteryl ester is transported to the liver. So far, little is known about the regulation of the express
Externí odkaz:
https://doaj.org/article/4e54532f64164e78b43c77ec00811a5e