Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Omar Janneh"'
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Akademický článek
Interactions of Tenofovir, Lamivudine, Abacavir and Didanosine in Primary Human Cells
Autor: Saye H. Khoo, Omar Janneh
Publikováno v: Pharmaceutics, Vol 3, Iss 2, Pp 326-337 (2011)
Certain triple nucleoside/tide reverse transcriptase inhibitor (NRTI) regimens containing tenofovir (TDF) have been associated with rapid early treatment failure. The mechanism is unknown, but may be at the level of drug transport. We measured the li
Externí odkaz: https://doaj.org/article/1124f8e35ab94065b35a43e30ff64c82
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2
Akademický článek
Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor.
Autor: Mayel Gharanei, Afthab Hussain, Omar Janneh, Helen Maddock
Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77713 (2013)
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure. Given the multiple beneficial effects of the mitochondrial division inhi
Externí odkaz: https://doaj.org/article/e10ea02ec6cd46ef9ebab9070811f10a
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3
Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore
Autor: Mayel Gharanei, Omar Janneh, Helen Maddock, Afthab Hussain
Publikováno v: Toxicology and Applied Pharmacology. 268:149-156
Chemotherapeutic agents such as doxorubicin are known to cause or exacerbate cardiovascular cell death when an underlying heart condition is present. However, the mechanism of doxorubicin-induced cardiotoxicity is unclear. Here we assess the cardioto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedd63f5c693be38db75004c0a8cdfd5
https://doi.org/10.1016/j.taap.2012.12.003
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4
Evaluation of antimalarial, free-radical-scavenging and insecticidal activities of Artemisia scoparia and A. Spicigera, Asteraceae
Autor: Lutfun Nahar, Hossein Nazemiyeh, Ardalan Pasdaran, Satyajit D. Sarker, Fariba Heshmati Afshar, Abbas Delazar, Omar Janneh
Publikováno v: Revista Brasileira de Farmacognosia, Vol 21, Iss 6, Pp 986-990 (2011)
Revista Brasileira de Farmacognosia v.21 n.6 2011
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
Revista Brasileira de Farmacognosia, Volume: 21, Issue: 6, Pages: 986-990, Published: 12 AUG 2011
Artemisia species (Asteraceae), widespread throughout the world, are a group of important medicinal plants. The extracts of two medicinal plants of this genus, Artemisia scoparia Waldst. & Kit. and A. spicigera C. Koch, were evaluated for potential a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aee32e090c2dd657d31c930284f2c9d
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600008
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5
Composition, antioxidant and chemotherapeutic properties of the essential oils from two Origanum species growing in Pakistan
Autor: Omar Janneh, Abdullah Ijaz Hussain, Satyajit D. Sarker, Shazia Rasheed, Poonam S. Nigam, Farooq Anwar
Publikováno v: Revista Brasileira de Farmacognosia, Vol 21, Iss 6, Pp 943-952 (2011)
Revista Brasileira de Farmacognosia v.21 n.6 2011
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
Revista Brasileira de Farmacognosia, Volume: 21, Issue: 6, Pages: 943-952, Published: 09 SEP 2011
The GC-MS analyses of Origanum majorana L. (OME) and Origanum vulgare L. (OVE), Lamiaceae, essential oils helped identification of 39 (96.4% of the total oils) and 43 (92.9% of the total oils) components, respectively. The major constituents of OME w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c87b2d518cab8f64e4987311a6d4e58
https://doi.org/10.1590/s0102-695x2011005000165
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6
Glutathione transferase-P1-1 binding with naturally occurring ligands: assessment by docking simulations
Autor: Pamela J. Magee, Poonam Singh Nee Nigam, Anupam J. Das, Sreeda Chalil, Richard Owusu-Apenten, Omar Janneh
Publikováno v: Journal of Biophysical Chemistry. :401-407
Glutathione transferase-P1-1 (hGSTP1-1), which is associated with acquired drug resistance in some tumour cells, requires two identical subunits for full activity. Naturally occurring inhibitors for GSTP1-1 quaternary structure could be interesting t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e96f5ee7e1f5ea60c9ed1cc115d76e5c
https://doi.org/10.4236/jbpc.2011.24046
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7
Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes
Autor: Christoph Wyen, Peter Chiba, Omar Janneh, Saye Khoo, Elizabeth Jones, David Back, Patrick G. Bray
Publikováno v: Journal of Antimicrobial Chemotherapy. 65:906-916
BACKGROUND The intracellular and plasma concentrations of HIV protease inhibitors (HPIs) vary widely in vivo. It is unclear whether there is a concentration-dependent effect of HPIs such that at increasing concentration they may either block their ow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9060b1c85441bbc4b145dbe7b8eec579
https://doi.org/10.1093/jac/dkq082
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8
The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes
Autor: Andrew Owen, David Back, Patrick G. Bray, Munir Pirmohamed, Omar Janneh
Publikováno v: British Journal of Pharmacology. 159:484-493
Background and purpose: Cultured pre-adipocytes accumulate and metabolize zidovudine (ZDV), but its mode of accumulation into these cells is unclear. We investigated the mode of accumulation of [3H]-ZDV, and the impact of changes in external pH and m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42bde82c5047f8d042531c88f1fbd9ab
https://doi.org/10.1111/j.1476-5381.2009.00552.x
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9
Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes
Autor: Becky Chandler, Sorcha Evans, David Back, Saye Khoo, Claire Jenkinson, Omar Janneh, Andrew Owen, Wai San Kwan, Ruben C. Hartkoorn
Publikováno v: Journal of Antimicrobial Chemotherapy. 64:1002-1007
Background Interaction of antiretrovirals with drug transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), breast cancer resistance protein (BCRP) and solute carrier organic anion transporter (SLCO) may influence t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4d90e6b6cf51c0f77d5108f73c03a1
https://doi.org/10.1093/jac/dkp335
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10
Antitumour and antimalarial activity of artemisinin–acridine hybrids
Autor: Jill Davies, Tafadzwa Charidza, Miriam E. Kennedy, B. Kevin Park, Amy E. Mercer, Ivo Piantanida, Michael Jones, Paul M. O'Neill, Jonathan Baird, Omar Janneh, Patrick G. Bray, Richard Cosstick, Paul A. Stocks, Sarah L. Rawe, Stephen A. Ward, Louise La Pensee
Publikováno v: Articles
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2-4-fold increase in activity against HL60, MDA-MB-231 and MCF-7
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16dfc301f102ae95bee6407f88e87303
https://doi.org/10.1016/j.bmcl.2009.02.028
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