Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Omar Hedaya"'
Autor:
Jiangbin Wu, Kadiam C Venkata Subbaiah, Feng Jiang, Omar Hedaya, Amy Mohan, Tingting Yang, Kevin Welle, Sina Ghaemmaghami, Wai Hong Wilson Tang, Eric Small, Chen Yan, Peng Yao
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-20 (2020)
Abstract Aberrant expression of mitochondrial proteins impairs cardiac function and causes heart disease. The mechanism of regulation of mitochondria encoded protein expression during cardiac disease, however, remains underexplored. Here, we show tha
Externí odkaz:
https://doaj.org/article/4538a4478f1142fd93fb22b37a9c6ce5
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1326-1338 (2019)
Alteration of RNA structure by environmental signals is a fundamental mechanism of gene regulation. For example, the riboswitch is a noncoding RNA regulatory element that binds a small molecule and causes a structural change in the RNA, thereby regul
Externí odkaz:
https://doaj.org/article/fbeb3a4d4120468ca3312a1b485c3b7f
Autor:
Jiangbin Wu, Kadiam C Venkata Subbaiah, Omar Hedaya, Si Chen, Joshua Munger, Wai Hong Wilson Tang, Chen Yan, Peng Yao
Publikováno v:
bioRxiv
AimsMitochondria play a vital role in cellular metabolism and energetics and support normal cardiac function. Disrupted mitochondrial function and homeostasis cause a variety of heart diseases. Fam210a (family with sequence similarity 210 member A),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0d59d4c7eeca08131782bd967b19d5
https://europepmc.org/articles/PMC10245825/
https://europepmc.org/articles/PMC10245825/
Publikováno v:
Circulation Research. 131
Translation of upstream open reading frames (uORFs) typically abrogates translation for the main ORF (mORF) and regulates protein expression. uORFs are present in nearly 50% of messenger RNA (mRNA) transcripts, but their impact and regulation on biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63884c9fecea072afce3ddf69825c1a0
https://doi.org/10.1161/res.131.suppl_1.p2055
https://doi.org/10.1161/res.131.suppl_1.p2055
Publikováno v:
Circulation. 144
Mitochondria play fundamental roles in maintaining cellular metabolism and energetics and supporting normal myocardial function. Disturbed cardiac mitochondrial homeostasis causes m itochondrial dysfunction associated with c ardiomyopathy (MC) in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::471e608291b5b979c82e4570bf8f6a85
https://doi.org/10.1161/circ.144.suppl_1.12253
https://doi.org/10.1161/circ.144.suppl_1.12253
Publikováno v:
Circulation Research. 129
Mitochondria play fundamental roles in supporting healthy myocardium function. Disturbed cardiac mitochondrial homeostasis causes mitochondrial dysfunction associated with cardiomyopathy in humans and mice. Recent genome-wide association studies (GWA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76809dd49dbbcf6fabbc0ad742c3b4c7
https://doi.org/10.1161/res.129.suppl_1.403
https://doi.org/10.1161/res.129.suppl_1.403
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1326-1338 (2019)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Alteration of RNA structure by environmental signals is a fundamental mechanism of gene regulation. For example, the riboswitch is a noncoding RNA regulatory element that binds a small molecule and causes a structural change i
Alteration of RNA structure by environmental signals is a fundamental mechanism of gene regulation. For example, the riboswitch is a noncoding RNA regulatory element that binds a small molecule and causes a structural change i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b797c7efdd13f1dabc2eb99c2b2505d8
https://doi.org/10.1016/j.csbj.2019.10.001
https://doi.org/10.1016/j.csbj.2019.10.001
Publikováno v:
Genes & Development. 31:1483-1493
While microRNAs (miRNAs) regulate the vast majority of protein-encoding transcripts, little is known about how miRNAs themselves are degraded. We recently described Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay (TumiD) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbac20975878c2aac1662a0259eb65bc
https://doi.org/10.1101/gad.303537.117
https://doi.org/10.1101/gad.303537.117
Autor:
Eric J. Small, Chen Yan, Omar Hedaya, Jiangbin Wu, W.H. Wilson Tang, Feng Jiang, Peng Yao, Kadiam C Venkata Subbaiah
Publikováno v:
Circulation Research. 125
Rationale: Translational control is a critical regulatory step in altering protein synthesis under disease conditions. Aberrant synthesis of mitochondrial proteins impairs cardiac function and causes heart disease. However, the mechanism of translati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588883e09d09bfa392e85fc35ad266fb
https://doi.org/10.1161/res.125.suppl_1.327
https://doi.org/10.1161/res.125.suppl_1.327
Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine produced by monocytes/macrophage that plays a pathological role in rheumatoid arthritis (RA). In this study, we investigate the effect of thymoquinone (TQ), a phytochemical found in Nig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2432e8e65f785312d32faf1f26a4e062
https://europepmc.org/articles/PMC4549173/
https://europepmc.org/articles/PMC4549173/