Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Omar Hauache"'
Autor:
Ana Claudia Ramalho, Marise Lazaretti-Castro, Omar Hauache, José Gilberto Vieira, Edmilson Takata, Francisco Cafalli, Fernando Tavares
Publikováno v:
São Paulo Medical Journal, Vol 119, Iss 2, Pp 48-53
CONTEXT: It is believed that about 25% of menopausal women in the USA will exhibit some kind of fracture as a consequence of osteoporosis. Fractures of the proximal femur are associated with a greater number of deaths and disabilities and higher medi
Externí odkaz:
https://doaj.org/article/3b63046aac5148988e0a320f5be588cb
Publikováno v:
Endocrinology. 141:4156-4163
Naturally occurring mutations identified in subjects with autosomal dominant hypocalcemia (ADH) and the calcimimetic compound, R-568, have both been reported to increase Ca2+ sensitivity of the Ca2+ receptor (CaR). To gain insight into their mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93171bd0083ce191a42d9d3a2162bbdd
https://doi.org/10.1210/endo.141.11.7753
https://doi.org/10.1210/endo.141.11.7753
Publikováno v:
Journal of Biological Chemistry. 275:16382-16389
The 612-residue extracellular domain of the human Ca(2+) receptor (hCaR) has been speculated to consist of a Venus's-flytrap domain (VFT) and a cysteine-rich domain. We studied the function of the hCaR Cys-rich domain by using mutagenesis and chimera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3415e5e2e3e038d0ac1492921f8db825
https://doi.org/10.1074/jbc.m000277200
https://doi.org/10.1074/jbc.m000277200
Publikováno v:
Endocrine. 13:63-70
We studied the activity of mutants involving the aminoterminal extracellular, seven-transmembrane (7TM) and carboxy-terminal tail domains of the human Ca2+ receptor to gain insight into the functional interactions between these domains during recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a088a4f75d0656390070aec1ecb5b6
https://doi.org/10.1385/endo:13:1:63
https://doi.org/10.1385/endo:13:1:63
Autor:
Allen M. Spiegel, Paul K. Goldsmith, Benjamin C. Hauschild, Peter J. Steinbach, Omar Hauache, Kausik Ray
Publikováno v:
Journal of Biological Chemistry. 274:27642-27650
We analyzed the effect of substituting serine for each of the 19 cysteine residues within the amino-terminal extracellular domain of the human Ca(2+) receptor on cell surface expression and receptor dimerization. C129S, C131S, C437S, C449S, and C482S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f2e0e6a0a6c1188c480b1e611b77147
https://doi.org/10.1074/jbc.274.39.27642
https://doi.org/10.1074/jbc.274.39.27642
Publikováno v:
FEBS letters. 448(1)
A missense mutation, A843E, in the seventh transmembrane domain of the human Ca2+ receptor, identified in a subject with autosomal dominant hypocalcemia, was found to cause a constitutive activation while at the same time lowering the maximal respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8c9fb1c72b10721f73f2d55ffa9545
https://pubmed.ncbi.nlm.nih.gov/10217436
https://pubmed.ncbi.nlm.nih.gov/10217436