Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Omar H. Cabrera"'
Autor:
Nemanja Useinovic, Stefan Maksimovic, Cole Liechty, Omar H. Cabrera, Nidia Quillinan, Vesna Jevtovic-Todorovic
Publikováno v:
British Journal of Anaesthesia. 129:555-566
General anaesthesia in the neonatal period has detrimental effects on the developing mammalian brain. The impact of underlying inflammation on anaesthesia-induced developmental neurotoxicity remains largely unknown.Postnatal day 7 (PND7) rats were ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96ecb808ae2079c26b1ad430e2308e0
https://doi.org/10.1016/j.bja.2022.05.008
https://doi.org/10.1016/j.bja.2022.05.008
Publikováno v:
Biol Reprod
Each year, millions of infants and children are anesthetized for medical and surgical procedures. Yet, a substantial body of preclinical evidence suggests that anesthetics are neurotoxins that cause rapid and widespread apoptotic cell death in the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b177b95e9f49800b18e4a64fc339877d
https://doi.org/10.1093/biolre/ioab136
https://doi.org/10.1093/biolre/ioab136
Publikováno v:
Br J Anaesth
Summary Exposure to anaesthetic drugs during the fetal or neonatal period induces widespread neuronal apoptosis in the brains of rodents and non-human primates. Hundreds of published preclinical studies and nearly 20 clinical studies have documented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73fa507f21ba07cd80fdf51a5c50fb7
https://doi.org/10.1016/j.bja.2019.12.032
https://doi.org/10.1016/j.bja.2019.12.032
Autor:
Francesca M. Manzella, Omar H. Cabrera, Davis Wilkey, Brier Fine-Raquet, Jelena Klawitter, Kathiresan Krishnan, Douglas F. Covey, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Publikováno v:
British journal of anaesthesia.
The novel synthetic neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) blocks T-type calcium channels but does not directly modulate neuronal γ-aminobutyric acid type A (GABAWe used a combination of behavioural loss of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1feb1722d96ec1ca0780e87155700482
https://pubmed.ncbi.nlm.nih.gov/36428160
https://pubmed.ncbi.nlm.nih.gov/36428160
Autor:
Vesna Jevtovic-Todorovic, Vesna Tesic, Nidia Quillinan, Omar H. Cabrera, Quy Tat, Shelby E. Chastain-Potts
Publikováno v:
Mol Neurobiol
Large body of animal work and emerging clinical findings have suggested that early exposure to anesthetics may result in increased risk of learning disabilities and behavioral impairments [1–4]. Recent studies have begun to investigate anesthesia-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec762fa346273eedbe52dc5fa122313
https://doi.org/10.1007/s12035-019-01752-0
https://doi.org/10.1007/s12035-019-01752-0
Autor:
Nathan R. Kerr, Omar H. Cabrera, Tom E. Childs, Taylor J. Kelty, Francesca M. Manzella, Dennis K. Miller, Jacob D. Brown, Frank W. Booth, Michael D. Roberts, George T. Taylor
Publikováno v:
Neuroscience letters. 753
Physical inactivity is positively associated with anxiety and depression. Considering physical inactivity, anxiety, and depression each have a genetic basis for inheritance, our lab used artificial selectively bred low-voluntary running (LVR) and wil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b34602fbcbca36bf842cea3b9dddfdb
https://pubmed.ncbi.nlm.nih.gov/33785378
https://pubmed.ncbi.nlm.nih.gov/33785378
Publikováno v:
Hormones and Behavior. 90:84-89
Women and non-human females have surprisingly high levels of circulating testosterone, yet the effects of androgens on non-reproductive behaviors, including cognition, of females are not well characterized. The current project used an aromatase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c59d55e5084433b9a4555be41413a26
https://doi.org/10.1016/j.yhbeh.2017.02.011
https://doi.org/10.1016/j.yhbeh.2017.02.011
Autor:
Francesca M. Manzella, Gregory A. Dissen, Katie J. Schenning, Kevin K. Noguchi, Lauren D. Martin, Omar H. Cabrera, Ansgar M. Brambrink
Publikováno v:
Neurotoxicology and Teratology. 60:63-68
Previously we reported that a 5-hour exposure of 6-day-old (P6) rhesus macaques to isoflurane triggers robust neuron and oligodendrocyte apoptosis. In an attempt to further describe the window of vulnerability to anesthetic neurotoxicity, we exposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a79f84375f5b41c6adfe8b38f866df9
https://doi.org/10.1016/j.ntt.2016.11.006
https://doi.org/10.1016/j.ntt.2016.11.006
Autor:
Nuri B. Farber, Brant S. Swiney, Kevin K. Noguchi, Patricia Salinas-Contreras, Omar H. Cabrera, Shawn O'Connor, Sukrit Singh, Joseph D. Dougherty
Publikováno v:
The Journal of Maternal-Fetal & Neonatal Medicine. 30:2156-2162
Glucocorticoids (GCs) are used to improve respiratory mechanics in preterm infants despite clinical evidence linking neonatal GC therapy to cerebellar pathology. In developing mouse cerebellum, the GC dexamethasone (DEX) causes rapid GC-induced neura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9082e41a5a70f4b1c30b01db3f380d
https://doi.org/10.1080/14767058.2016.1241763
https://doi.org/10.1080/14767058.2016.1241763
Publikováno v:
Mol Neurobiol
BACKGROUND: The cation-chloride cotransporters Na(+)–K(+)–2Cl(−)–1 (NKCC1) and K(+)–2Cl(−)–2 (KCC2) critically regulate neuronal responses to gamma-aminobutyric acid (GABA). NKCC1 renders GABA excitatory in immature neurons while expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ae5ed70690b8c4a3c19b66f60144a4
https://pubmed.ncbi.nlm.nih.gov/31493242
https://pubmed.ncbi.nlm.nih.gov/31493242