Výsledky vyhledávání - "Omar Elgazzar"

Akademický článek

Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis

Autor: Nour Eissa, Omar Elgazzar, Hayam Hussein, Geoffrey N. Hendy, Charles N. Bernstein, Jean-Eric Ghia

Publikováno v: Biomedicines, Vol 9, Iss 2, p 134 (2021)

Ulcerative colitis (UC) is characterized by modifying alternatively activated macrophages (AAM) and epithelial homeostasis. Chromogranin-A (CHGA), released by enterochromaffin cells, is elevated in UC and is implicated in inflammation progression. CH

Externí odkaz: https://doaj.org/article/b8304b70d84643fe88730969c536e07e

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Akademický článek

Reactivation of Intestinal Inflammation Is Suppressed by Catestatin in a Murine Model of Colitis via M1 Macrophages and Not the Gut Microbiota

Autor: Mohammad F. Rabbi, Nour Eissa, Peris M. Munyaka, Laëtitia Kermarrec, Omar Elgazzar, Ehsan Khafipour, Charles N. Bernstein, Jean Eric Ghia

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

While there is growing awareness of a relationship between chromogranin-A (CHGA) and susceptibility to inflammatory conditions, the role of human catestatin [(hCTS); CHGA352–67] in the natural history of established inflammatory bowel disease is no

Externí odkaz: https://doaj.org/article/172bc0ee60d54f618404f4c44bd854a1

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Semaphorin 3E regulates apoptosis in the intestinal epithelium during the development of colitis

Autor: Abdoulaye Diarra, Hayam Hussein, Nour Eissa, Omar Elgazzar, Jean-Eric Ghia, Abdelilah S. Gounni, Charles N. Bernstein

Publikováno v: Biochemical Pharmacology. 166:264-273

Semaphorin 3E (SEMA3E) has emerged as an axon-guiding molecule that regulates various biological processes including the immune responses and apoptosis. However, its role in the pathophysiology of colitis remains elusive. We investigated the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612c6cf54e15aea5b05134328752bd34
https://doi.org/10.1016/j.bcp.2019.05.029

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Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis

Autor: Geoffrey N. Hendy, Hayam Hussein, Nour Eissa, Jean-Eric Ghia, Omar Elgazzar, Charles N. Bernstein

Publikováno v: Biomedicines
Volume 9
Issue 2
Biomedicines, Vol 9, Iss 134, p 134 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c66ac3de55d8ecc988aa5b252024d72

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Chromofungin (CHR: CHGA47-66) is downregulated in persons with active ulcerative colitis and suppresses pro-inflammatory macrophage function through the inhibition of NF-κB signaling

Autor: Hayam Hussein, Omar Elgazzar, Laëtitia Kermarrec, Nour Eissa, Charles N. Bernstein, Marie-Hélène Metz-Boutigue, Jean-Eric Ghia

Publikováno v: Biochemical Pharmacology. 145:102-113

Chromogranin-A (CHGA) is a prohormone secreted by neuroendocrine cells and is a precursor of several bioactive peptides, which are implicated in different and distinctive biological and immune functions. Chromofungin (CHR: CHGA47-66) is a short pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e285b828d534c626d7302d497edb5bd
https://doi.org/10.1016/j.bcp.2017.08.013

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