Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Omar El Ayoubi"'
Autor:
Johanna Pohl, Angela Litz, Omar El Ayoubi, Armando Rodríguez-Alfonso, Ludger Ständker, Mirja Harms, Jan Münch, Hassan Jumaa, Moumita Datta
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8306 (2024)
Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is characterized by reciprocal chromosomal translocation between chromosome 9 and 22, leading to the expression of constitutively active oncogenic BCR–ABL1 fusion protein. CXC
Externí odkaz:
https://doaj.org/article/8e97b17c250b4157ac1af189d8461786
Autor:
Antonella Nicolò, Timm Amendt, Omar El Ayoubi, Marc Young, Stephanie Finzel, Makbule Senel, Reinhard E. Voll, Hassan Jumaa
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation due to autoantibodies targeting multiple self-proteins. Most patients with poor prognosis show elevated titers of IgM antibodies specifically binding to IgG. Such autor
Externí odkaz:
https://doaj.org/article/6859fa3d505e4ce3bf14bb6b4b83ddae
Autor:
Lennart Lenk, Michela Carlet, Fotini Vogiatzi, Lea Spory, Dorothee Winterberg, Antony Cousins, Michaela Vossen-Gajcy, Olta Ibruli, Christian Vokuhl, Gunnar Cario, Omar El Ayoubi, Lisa Kramer, Matthias Ritgen, Monika Brüggemann, Robert Häsler, Martin Schrappe, Stephan Fuhrmann, Christina Halsey, Irmela Jeremias, Elias Hobeika, Hassan Jumaa, Ameera Alsadeq, Denis M. Schewe
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment
Externí odkaz:
https://doaj.org/article/45d481a21f3e44e49b4f84076c7e9181
Autor:
Anila Vadakumchery, Hemin Faraidun, Omar El Ayoubi, Issame Outaleb, Vera Schmid, Hend Abdelrasoul, Timm Amendt, Ahmad Khadour, Corinna Setz, Katharina Göhring, Karoline Lodd, Christoffer Hitzing, Alabbas Alkhatib, Mayas Bilal, Julian Benckendorff, Abdul Kader Al Shugri, Cord Herbert Brakebusch, Niklas Engels, Moumita Datta, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The generation, differentiation, survival and activation of B cells are coordinated by signals emerging from the B cell antigen receptor (BCR) or its precursor, the pre-BCR. The adaptor protein SLP65 (also known as BLNK) is an important signaling fac
Externí odkaz:
https://doaj.org/article/bba221cfcb304def8ce9db2a80eaa6fd
Autor:
Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk, Ahmad Khadour, Marc Young, Omar El Ayoubi, Fotini Vogiatzi, Markus Krämer, Vera Schmid, Zhengshan Chen, Yasar Yousafzai, Gunnar Cario, Martin Schrappe, Markus Müschen, Christina Halsey, Medhanie A. Mulaw, Denis M. Schewe, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism,
Externí odkaz:
https://doaj.org/article/a25003f7a49e4b7f9022e8001e0418c9
Autor:
Timm Amendt, Omar El Ayoubi, Alexandra T. Linder, Gabriele Allies, Marc Young, Corinna S. Setz, Hassan Jumaa
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mature B cells co-express IgM and IgD B cell antigen receptors (BCR) on their surface. While IgM BCR expression is already essential at early stages of development, the role of the IgD-class BCR remains unclear as most B cell functions appeared uncha
Externí odkaz:
https://doaj.org/article/911d05e2f9d347359726e9b21f860e89
Autor:
Loutfi Guennoun Abdelmounaim, Mohammed Khouchoua, Nouha Nhiri, Naouale Biougnache, Mohamed Adnane Rhaidouni, Ouassila Laouji, Fatima El Hadraoui, Safae Habib Rabbi, Omar El Ayoubi, Omar Alaoui, Samir Messnan, Said Lafkir
Publikováno v:
Open Journal of Obstetrics and Gynecology. 12:1320-1327
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70d1e1a5ead86e7b733521f341e597b0
https://doi.org/10.4236/ojog.2022.1212116
https://doi.org/10.4236/ojog.2022.1212116
Autor:
Timm Amendt, Gabriele Allies, Antonella Nicolò, Omar El Ayoubi, Marc Young, Tamás Röszer, Corinna S. Setz, Klaus Warnatz, Hassan Jumaa
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(6)
SignificanceThe random nature of antibody repertoire generation includes the potential of producing autoantibodies recognizing self-structures. It is believed that establishing immunological tolerance and prevention of autoimmune diseases require the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec9540e9c8af314db134242526dca23
https://pubmed.ncbi.nlm.nih.gov/35131852
https://pubmed.ncbi.nlm.nih.gov/35131852
Autor:
Antonella Nicolò, Timm Amendt, Tamás Röszer, Omar El Ayoubi, Marc Young, Klaus Warnatz, Corinna S. Setz, Hassan Jumaa, Gabriele Allies
SummaryHomeostasis of metabolism by hormone production is crucial to maintain physiological integrity and disbalance can cause severe metabolic disorders such as diabetes mellitus. Here, we show that antibodies recognizing insulin are key regulators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ae0b0a966ef699d0cdfbc0a093d0dd
https://doi.org/10.1101/2021.08.10.455644
https://doi.org/10.1101/2021.08.10.455644
Autor:
Michaela Vossen-Gajcy, Olta Ibruli, Martin Schrappe, Antony Cousins, Lisa Kramer, Irmela Jeremias, Dorothee Winterberg, Matthias Ritgen, Fotini Vogiatzi, Stephan Fuhrmann, Denis M. Schewe, Robert Häsler, Hassan Jumaa, Christian Vokuhl, Monika Brüggemann, Chris Halsey, Lennart Lenk, Omar El Ayoubi, Lea Spory, A Alsadeq, Gunnar Cario, Elias Hobeika, Michela Carlet
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Comm. Biol. 4:73 (2021)
communications biology
Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Comm. Biol. 4:73 (2021)
communications biology
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd00c128fdbc6db3262d75f84457181
http://europepmc.org/articles/PMC7810877
http://europepmc.org/articles/PMC7810877