Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Omar C. Logue"'
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 12 (2017)
BackgroundPreeclampsia is a hypertensive syndrome that complicates 3% to 5% of pregnancies in the United States. Preeclampsia originates from an improperly vascularized and ischemic placenta that releases factors that drive systemic pathophysiology.
Externí odkaz:
https://doaj.org/article/e156a79a396049f3ae33d9627d9fa59f
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 16, p 4051 (2019)
Offspring of preeclampsia patients have an increased risk of developing neurological deficits and cognitive impairment. While low placental perfusion, common in preeclampsia and growth restriction, has been linked to neurological deficits, a causativ
Externí odkaz:
https://doaj.org/article/d7f1e9007a944cb0a2efd6f5f8500360
Autor:
Omar C. Logue, Gene L. Bidwell, Eric M. George, Heather Chapman, Kyle H. Moore, Adrian C Eddy
Publikováno v:
Hypertension. 74
Preeclampsia is often characterized by high circulating levels of sFlt-1 and low VEGF and PlGF. VEGF supplementation therapy has shown promise in preclinical models, however rapid plasma clearance hampers the use of VEGF as a therapeutic. We fused hu
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 16
International Journal of Molecular Sciences, Vol 20, Iss 16, p 4051 (2019)
Volume 20
Issue 16
International Journal of Molecular Sciences, Vol 20, Iss 16, p 4051 (2019)
Offspring of preeclampsia patients have an increased risk of developing neurological deficits and cognitive impairment. While low placental perfusion, common in preeclampsia and growth restriction, has been linked to neurological deficits, a causativ
Publikováno v:
The FASEB Journal. 33
Publikováno v:
Clinical Science. 130:1417-1434
Preeclampsia (PE) is a form of gestational hypertension that complicates ∼5% of pregnancies worldwide. Over 70% of the fatal cases of PE are attributed to cerebral oedema, intracranial haemorrhage and eclampsia. The aetiology of PE originates from
Publikováno v:
Hypertension. 72
Preeclampsia (PE) complicates 3-5% of pregnancies with gestational hypertension, and programs later life outcomes in both mother and offspring. The unknown etiology arises from abnormal remodeling of the maternal spiral arteries, creating an ischemic
Publikováno v:
Hypertension. 72
Placental ischemia is thought to be the initiating event in the pathophysiology of preeclampsia, a hypertensive disorder of pregnancy. Previous studies have shown that placental ischemia in the rat, induced by surgically reducing uterine perfusion pr
Publikováno v:
The FASEB Journal. 32
Introduction Fusion of therapeutic agents to Elastin-like Polypeptide (ELP) is a novel drug delivery strategy for prevention of placental drug transfer. Previous studies have used a 60 kDa ELP tag for this purpose. However, placental transfer of ELP
ELP‐VEGF Treatment Improves the Maternal Syndrome of Preeclampsia in the Dahl Salt Sensitive (S) Rat
Autor:
Michael R. Garrett, Kenji J. Maeda, Gene L. Bidwell, Jennifer M. Sasser, Courtney A. Ross, Omar C. Logue
Publikováno v:
The FASEB Journal. 32