Výsledky vyhledávání - "Omar Almakki"

Akademický článek

Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice

Autor: Atsuki En, Hanumakumar Bogireddi, Briana Thomas, Alexis V. Stutzman, Sachie Ikegami, Brigitte LaForest, Omar Almakki, Peter Pytel, Ivan P. Moskowitz, Kohta Ikegami

Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114284- (2024)

Summary: Nuclear envelope (NE) ruptures are emerging observations in Lamin-related dilated cardiomyopathy, an adult-onset disease caused by loss-of-function mutations in Lamin A/C, a nuclear lamina component. Here, we test a prevailing hypothesis tha

Externí odkaz: https://doaj.org/article/92b6c414548a4b3e8fe247bfe0d2b497

Zobrazit plný text záznamu

Abstract MP230: Nuclear Rupture In A Mouse Model Of Lmna -related Cardiomyopathy Causes Cytoplasmic Exposure Of The Proinflammatory Signaling Protein Hmgb1

Autor: Omar Almakki, Alexis V. Stutzman, Sachie Ikegami, Kohta Ikegami, Sunny Yang Liu, Ivan P. Moskowitz, Ozanna Burnicka-Turek

Publikováno v: Circulation Research. 129

Cardiomyopathies caused by mutations in LMNA, encoding nuclear Lamin A/C, are highly malignant and prevalent. How LMNA mutations cause cardiomyopathies remains unknown. We characterized cellular, molecular, and pathological evolution of mouse models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18bae1267be4a4d3701f6e1dbebd6ca8
https://doi.org/10.1161/res.129.suppl_1.mp230

Zobrazit plný text záznamu

Abstract 508: Nuclear Lamins At Enhancers: A New Hypothesis for Laminopathies

Autor: Sunny Yang Liu, Natalia Ayres, Alexis V. Stutzman, Omar Almakki, Jason D. Lieb, Sachie Ikegami, Kohta Ikegami, Stefano Secchia, Ivan P. Moskowitz

Publikováno v: Circulation Research. 127

The segregation of heterochromatin domains (LADs) at the nuclear periphery by the nuclear lamina, composed by polymerized nuclear Lamin A/C, provides a longstanding paradigm for the control of gene expression and for the mechanisms underlying Lamin-A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdebf16a7bbcb8032d33ba483795ce23
https://doi.org/10.1161/res.127.suppl_1.508

Zobrazit plný text záznamu

Phosphorylated Lamin A/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria

Autor: Ivan P. Moskowitz, Kohta Ikegami, Stefano Secchia, Jason D. Lieb, Omar Almakki

Publikováno v: Dev Cell

LMNA encodes nuclear lamin A/C that tethers lamina-associated heterochromatin domains (LADs) to the nuclear periphery. Point mutations in LMNA cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, but the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bc3a692936e97532b363ab8d8729be
https://europepmc.org/articles/PMC7201903/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání