Výsledky vyhledávání - "Omar A. Z. Tutakhel"

Akademický článek

NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity.

Autor: Omar A Z Tutakhel, Arthur D Moes, Marco A Valdez-Flores, Marleen L A Kortenoeven, Mathijs V D Vrie, Sabina Jeleń, Robert A Fenton, Robert Zietse, Joost G J Hoenderop, Ewout J Hoorn, Luuk Hilbrands, René J M Bindels

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176220 (2017)

Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of CNIs is hypertension. Renal salt transporters such as NCC are excreted

Externí odkaz: https://doaj.org/article/705850cf55534fe9a38c9803d808797d

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Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles

Publikováno v: J Am Soc Nephrol
Blijdorp, C J, Tutakhel, O A Z, Hartjes, T A, van den Bosch, T P P, van Heugten, M H, Rigalli, J P, Willemsen, R, Musterd-Bhaggoe, U M, Barros, E R, Carles-Fontana, R, Carvajal, C A, Arntz, O J, van de Loo, F A J, Jenster, G, Clahsen-van Groningen, M C, Cuevas, C A, Severs, D, Fenton, R A, van Royen, M E, Hoenderop, J G J, Bindels, R J M & Hoorn, E J 2021, ' Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles ', Journal of the American Society of Nephrology : JASN, vol. 32, no. 5, pp. 1210-1226 . https://doi.org/10.1681/ASN.2020081142
Journal of the American Society of Nephrology, 32, 1210-1226
Journal of the American Society of Nephrology, 32(5), 1210-1226. American Society of Nephrology
Journal of the American Society of Nephrology, 32, 5, pp. 1210-1226

Background Urinary extracellular vesicles (uEVs) are a promising source for biomarker discovery, but optimal approaches for normalization, quantification, and characterization in spot urines are unclear. Methods Urine samples were analyzed in a water

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0c64668a5a8ea0fb9f5169d71f5c4d
https://pubmed.ncbi.nlm.nih.gov/33782170

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Role of the alternative splice variant of NCC in blood pressure control

Autor: Omar A. Z. Tutakhel, Hila Wardak, Jenny van der Wijst

Publikováno v: Channels, 12, 346-355
Channels
Channels, 12, 1, pp. 346-355

Contains fulltext : 196813.pdf (Publisher’s version ) (Open Access) The renal thiazide-sensitive sodium-chloride cotransporter (NCC), located in the distal convoluted tubule (DCT) of the kidney, plays an important role in blood pressure regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82cd8f0d86c650818b38480d5dbf69f
https://doi.org/10.1080/19336950.2018.1528820

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Functionomics of NCC mutations in Gitelman syndrome using a novel mammalian cell-based activity assay

Autor: Anne Blanchard, Sjoerd Verkaart, Sabina Jeleń, Cyrielle Treard, René J. M. Bindels, Marco A. Valdez-Flores, Rosa Vargas-Poussou, Omar A. Z. Tutakhel, Angel Valdez-Ortiz, Joost G. J. Hoenderop

Publikováno v: American Journal of Physiology : Renal Physiology, 311, 6, pp. F1159-F1167
American Journal of Physiology : Renal Physiology, 311, F1159-F1167

Contains fulltext : 172535.pdf (Publisher’s version ) (Closed access) Gitelman syndrome (GS) is an autosomal recessive salt-wasting tubular disorder resulting from loss-of-function mutations in the thiazide-sensitive NaCl cotransporter (NCC). Funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaf89efc2ab16b42dcd80e8a229911c
https://doi.org/10.1152/ajprenal.00124.2016

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Dominant functional role of the novel phosphorylation site S811 in the human renal NaCl cotransporter

Autor: Omar A. Z. Tutakhel, Frans Bianchi, Jenny van der Wijst, Daniël A Smits, René J. M. Bindels, Joost G. J. Hoenderop

Publikováno v: The FASEB Journal, 32(8), 4482-4493. FEDERATION AMER SOC EXP BIOL
The Faseb Journal, 32, 8, pp. 4482-4493
The Faseb Journal, 32, 4482-4493

The NaCl cotransporter (NCC) is essential for electrolyte homeostasis and control of blood pressure. The human SLC12A3 gene, which encodes NCC, gives rise to 3 isoforms, of which only the shortest isoform [NaCl cotransporter isoform 3 (NCC3)] has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b835cb8e27e6bc4b9a90a96eb8fdb4
https://research.rug.nl/en/publications/78d1abbf-4b78-45b7-abc1-a2512adc19cb

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Effects of a high-sodium/low-potassium diet on renal calcium, magnesium, and phosphate handling

Autor: Alexander H. J. Danser, Jenny van der Wijst, Caro Bos, Omar A. Z. Tutakhel, Joost G. J. Hoenderop, René J. M. Bindels, Ewout J. Hoorn

Publikováno v: American Journal of Physiology : Renal Physiology, 315, F110-F122
American Journal of Physiology-Renal Physiology, 315(1), F110-F122. American Physiological Society
American Journal of Physiology : Renal Physiology, 315, 1, pp. F110-F122

The distal convoluted tubule (DCT) of the kidney plays an important role in blood pressure regulation by modulating Na+reabsorption via the Na+-Cl−cotransporter (NCC). A diet containing high salt (NaCl) and low K+activates NCC, thereby causing Na+r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fafac0cd953f4f8f01b771a7d6164609
http://hdl.handle.net/2066/193539

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NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity

Autor: Ewout J. Hoorn, Omar A. Z. Tutakhel, Robert Zietse, Marleen L. A. Kortenoeven, Sabina Jeleń, Mathijs van de Vrie, Luuk B. Hilbrands, Robert A. Fenton, Joost G. J. Hoenderop, Arthur D. Moes, René J. M. Bindels, Marco A. Valdez-Flores

Publikováno v: Tutakhel, O A Z, Moes, A D, Valdez-Flores, M A, Kortenoeven, M L A, Vrie, M V D, Jeleń, S, Fenton, R A, Zietse, R, Hoenderop, J G J, Hoorn, E J, Hilbrands, L & Bindels, R J M 2017, ' NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity ', P L o S One, vol. 12, no. 4, pp. e0176220 . https://doi.org/10.1371/journal.pone.0176220
PLoS One (print), 12(4):e0176220. Public Library of Science
PLoS ONE
PLoS One, 12, 4
PLoS One, 12
PLoS ONE, Vol 12, Iss 4, p e0176220 (2017)

Contains fulltext : 174152.pdf (Publisher’s version ) (Open Access) Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b37a0210408e557e0da2e9f99ccf8e
https://doi.org/10.1371/journal.pone.0176220

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Hydrochlorothiazide treatment increases the abundance of the NaCl cotransporter in urinary extracellular vesicles of essential hypertensive patients

Autor: Ganesh Pathare, Omar A. Z. Tutakhel, Jacques W.M. Lenders, René J. M. Bindels, Luke M. Shelton, Mark van der Wel, Joost G. J. Hoenderop, Jaap Deinum

Publikováno v: American Journal of Physiology : Renal Physiology, 312, 6, pp. F1063-F1072
American Journal of Physiology : Renal Physiology, 312, F1063-F1072

The thiazide-sensitive NaCl cotransporter (NCC), located apically in distal convoluted tubule epithelia, regulates the fine-tuning of renal sodium excretion. Three isoforms of NCC are generated through alternative splicing of the transcript, of which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a4eacde667f5cd3598ff18820301e7
https://hdl.handle.net/2066/174544

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Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling

Autor: Omar A. Z. Tutakhel, Jaap Deinum, René J. M. Bindels, Marco A. Valdez-Flores, Jacques W.M. Lenders, Henrik Dimke, Sander R. Piersma, Sabina Jeleń, Joost G. J. Hoenderop, Connie R. Jimenez

Publikováno v: Tutakhel, O A Z, Jelen, S, Valdez-Flores, M, Dimke, H, Piersma, S R, Jimenez, C R, Deinum, J, Lenders, J W, Hoenderop, J G J & Bindels, R J M 2016, ' Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling ', American Journal of Physiology. Renal Physiology, vol. 310, no. 3, pp. F204-F216 . https://doi.org/10.1152/ajprenal.00429.2015
American Journal of Physiology : Renal Physiology, 310, 3, pp. F204-16
American Journal of Physiology : Renal Physiology, 310, F204-16
American Journal of Physiology. Renal Physiology, 310(3), F204-F216. American Physiological Society
Tutakhel, O A Z, Jeleń, S, Valdez-Flores, M, Dimke, H, Piersma, S R, Jimenez, C R, Deinum, J, Lenders, J W, Hoenderop, J G J & Bindels, R J M 2016, ' Alternative splice variant of the thiazide-sensitive NaCl cotransporter : a novel player in renal salt handling ', American Journal of Physiology: Renal Physiology, vol. 310, no. 3, pp. F204-F216 . https://doi.org/10.1152/ajprenal.00429.2015

The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. The human SLC12A3 gene, encoding NCC, gives rise to three isoforms. Only the third isoform has been extensively investigated. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3cf436a2c73bedcb255dc3e4c7a7de
https://pubmed.ncbi.nlm.nih.gov/26561651

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