Tristetraprolin promotes survival of mammary progenitor cells by restraining TNFα levels

Autor: Micaela Stedile, Angela Lara Montero, Martín Emilio García Solá, María Victoria Goddio, Inés Beckerman, Emilia Bogni, Marina Ayre, Zaira Naguila, Omar A. Coso, Edith C. Kordon

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2024)

Tristetraprolin (TTP) is an RNA binding protein that destabilizes mRNAs of factors involved in proliferation, invasiveness, and inflammation. Disruption of the gene that codes for TTP (Zfp36) led to severe arthritis, autoimmunity, cachexia and dermat

Externí odkaz: https://doaj.org/article/c53b07a7f9634f9c990f5df9c9fadcd6

KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi's sarcoma

Autor: Ethel Cesarman, Chiara Chiozzini, C. B. Cymeryng, Qi Ma, Agata D´Agostino, Omar A. Coso, Julian Naipauer, Daiana Sapochnik, Elizabeth Hyjek, Enrique A. Mesri, Pilar Eroles, María Victoria Medina, Lucas E. Cavallin

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Pathogens, Vol 16, Iss 10, p e1009006 (2020)
PLoS Pathogens

Kaposi’s sarcoma-associated herpesvirus (KSHV) vGPCR is a constitutively active G protein-coupled receptor that subverts proliferative and inflammatory signaling pathways to induce cell transformation in Kaposi’s sarcoma. Cyclooxygenase-2 (COX-2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1612a6002c88870352255535d12bab
https://pubmed.ncbi.nlm.nih.gov/33057440/

Regulation of the Expression of Heme Oxygenase-1: Signal Transduction, Gene Promoter Activation, and Beyond

Autor: Daiana Sapochnik, Martín E García Solá, Omar A. Coso, María Victoria Medina

Publikováno v: Antioxid Redox Signal

Significance: Heme oxygenase-1 (HO-1) is a ubiquitous 32-kDa protein expressed in many tissues and highly inducible. They catalyze the degradation of the heme group and the release of free iron, carbon monoxide, and biliverdin; the latter converted t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae8cd1ce0a7184d981cda61c755fce2
https://europepmc.org/articles/PMC7153632/

R-spondin3 Is Associated with Basal-Progenitor Behavior in Normal and Tumor Mammary Cells

Autor: Omar A. Coso, Anabella Srebrow, Roberto Meiss, Johanna M. Tocci, Edith C. Kordon, Martín E García Solá, María Victoria Goddio, Natalia Rubinstein, Carla M. Felcher, María Noel Zimberlin, Martín Carlos Abba

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

R-spondin3 (RSPO3) is a member of a family of secreted proteins that enhance Wnt signaling pathways in diverse processes, including cancer. However, the role of RSPO3 in mammary gland and breast cancer development remains unclear. In this study, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e465e6ac047a82af1a0e5a270a96a7
http://sedici.unlp.edu.ar/handle/10915/124844

Role of 3′-5′-cyclic adenosine monophosphate on the epidermal growth factor dependent survival in mammary epithelial cells

Autor: Diego M. Presman, Diego Y. Grinman, Carlos Davio, Omar A. Coso, Leonardo Romorini, Adali Pecci, Luciana Rocha-Viegas

Epidermal growth factor (EGF) has been suggested to play a key role in the maintenance of epithelial cell survival during lactation. Previously, we demonstrated that EGF dependent activation of PI3K pathway prevents apoptosis in confluent murine HC11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e123bca99af14d5df173e41eaba6900
http://www.sciencedirect.com/science/article/pii/S030372071530126X