Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis

Autor: Marta P, Pereira Morais, Omar, Kassaar, Stephen E, Flower, Robert J, Williams, Tony D, James, Jean M H, van den Elsen

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1855

Carbohydrate modification of proteins adds complexity and diversity to the proteome. However, undesired carbohydrate modifications also occur in the form of glycation, which have been implicated in diseases such as diabetes, Alzheimer's disease, auto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::274de0572344291baccdf3cd319b4e81
https://pubmed.ncbi.nlm.nih.gov/30426417

Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer's Disease

Autor: Rashmi K. Godbole, Mahesh J. Kulkarni, Robert J. Williams, Omar Kassaar, Kedar B. Batkulwar, Reema Banarjee

Publikováno v: Batkulwar, K, Godbole, R, Banarjee, R, Kassaar, O, Williams, R J & Kulkarni, M 2018, ' Advanced glycation end products modulate amyloidogenic APP processing and Tau phosphorylation: a mechanistic link between glycation and the development of Alzheimer’s disease ', ACS Chemical Neuroscience, vol. 9, no. 5, pp. 988-1000 . https://doi.org/10.1021/acschemneuro.7b00410

Advanced glycation end products (AGEs) are implicated in the pathology of Alzheimer's disease (AD), as they induce neurodegeneration following interaction with the receptor for AGE (RAGE). This study aimed to establish a mechanistic link between AGE-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90757f40d155c2c160454c8e89e3718
https://pubmed.ncbi.nlm.nih.gov/29384651

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer’s Disease

Autor: Su-Ying Xu, Bryony Jenkins, Paul T. Francis, Johannes Van Den Elsen, Robert J. Williams, Tony D. James, Omar Kassaar, Marta P. Pereira Morais, Emily L. Adam, Stephen G. Ward, Rosemary C. Chamberlain

Publikováno v: Scientific Reports
Kassaar, O, Morais, M P, Xu, S, Adam, E L, Chamberlain, R C, Jenkins, B, James, T, Francis, P T, Ward, S, Williams, R J & Van Den Elsen, J 2017, ' Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease ', Scientific Reports, vol. 7, 42874 . https://doi.org/10.1038/srep42874

Glucose and glucose metabolites are able to adversely modify proteins through a non-enzymatic reaction called glycation, which is associated with the pathology of Alzheimer’s Disease (AD) and is a characteristic of the hyperglycaemia induced by dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dfc9bb4a9b7d63f3a0822a3608e5bf
https://doi.org/10.1038/srep42874

Allosteric modulation of zinc speciation by fatty acids

Autor: Peter J. Sadler, Claudia A. Blindauer, Omar Kassaar, Esther M. Martin, James P. Barnett, Siavash Khazaipoul, Alan J. Stewart

Background: Serum albumin is the major protein component of blood plasma and is responsible for the circulatory transport of a range of small molecules that include fatty acids, hormones, metal ions and drugs. Studies examining the ligand-binding pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139b9edcc96736d213f8b125454ce09f
https://hdl.handle.net/10023/4105