Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Omar, Kabbarah"'
Autor:
Radia M. Johnson, Xueping Qu, Chu-Fang Lin, Ling-Yuh Huw, Avinashnarayan Venkatanarayan, Ethan Sokol, Fang-Shu Ou, Nnamdi Ihuegbu, Oliver A. Zill, Omar Kabbarah, Lisa Wang, Richard Bourgon, Felipe de Sousa e Melo, Chris Bolen, Anneleen Daemen, Alan P. Venook, Federico Innocenti, Heinz-Josef Lenz, Carlos Bais
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
ARID1A is an epigenetic regulator mutated in approximately 5% of non-hypermutated colorectal cancer tumors, however, its relationship with treatment response remains to be explored. Here, the authors suggest that ARID1A mutations may confer intrinsic
Externí odkaz:
https://doaj.org/article/4488b89ca7bf43bdb1d09041a86d2a0c
Autor:
Anneleen Daemen, Akshata R. Udyavar, Thomas Sandmann, Congfen Li, Linda J. W. Bosch, William O’Gorman, Yijin Li, Amelia Au-Yeung, Chikara Takahashi, Omar Kabbarah, Richard Bourgon, Priti Hegde, Carlos Bais, Meghna Das Thakur
Publikováno v:
PLoS ONE, Vol 16, Iss 12 (2021)
Background Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with a 5% 5-year survival rate for metastatic disease, yet with limited therapeutic advancements due to insufficient understanding of and inability to accurately capture
Externí odkaz:
https://doaj.org/article/ceb3d9ff0113422f8fd18c42ca9291dd
Autor:
Anthony Cao, Jiaqing Yi, Xinyan Tang, Christopher W. Szeto, Renyi Wu, Bing Wan, Xu Fang, Shou Li, Lei Wang, Lina Wang, Jing Li, Qiuping Ye, Tom Huang, Karl Hsu, Omar Kabbarah, Haiying Zhou
Publikováno v:
Cancer Research Communications. 2:1404-1417
Tumor-associated macrophages (TAM) are the most abundant immune cells in the tumor microenvironment. They consist of various subsets but primarily resemble the M2 macrophage phenotype. TAMs are known to promote tumor progression and are associated wi
Autor:
Hiroyasu Konno, Tracey Lin, Renyi Wu, Xinchuan Dai, Shou Li, Grace Wang, Min Chen, Wenying Li, Lina Wang, Bee-Chun Sun, Zhen Luo, Tom Huang, Yuping Chen, John Zhang, Qiuping Ye, David Bellovin, Bing Wan, Lishan Kang, Christopher Szeto, Karl Hsu, Omar Kabbarah
Publikováno v:
Cancer Research Communications. 2:937-950
CLDN18.2 (Claudin18.2)-targeting therapeutic antibodies have shown promising clinical efficacy in approximately 30% of gastric cancers expressing high levels of CLDN18.2 and less pronounced activity in low expressing malignancies. Here, we report tha
Autor:
Haiying Zhou, Omar Kabbarah, Karl Hsu, Tom Huang, Qiuping Ye, Jing Li, Lina Wang, Lei Wang, Shou Li, Xu Fang, Bing Wan, Renyi Wu, Christopher W. Szeto, Xinyan Tang, Jiaqing Yi, Anthony Cao
Tumor-associated macrophages (TAM) are the most abundant immune cells in the tumor microenvironment. They consist of various subsets but primarily resemble the M2 macrophage phenotype. TAMs are known to promote tumor progression and are associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062bcb4ff6350a3d0fc6471a979c92ba
https://doi.org/10.1158/2767-9764.c.6550896
https://doi.org/10.1158/2767-9764.c.6550896
Autor:
Haiying Zhou, Omar Kabbarah, Karl Hsu, Tom Huang, Qiuping Ye, Jing Li, Lina Wang, Lei Wang, Shou Li, Xu Fang, Bing Wan, Renyi Wu, Christopher W. Szeto, Xinyan Tang, Jiaqing Yi, Anthony Cao
Body weights of mice in HCC1954(A), SKOV3(B), ST-02-0077(C), FaDu (D), and Raji(E) xenograft efficacy studies shown in Figure 5 at days post-treatment as shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ae460c3cb0d72a6817344785c292c0
https://doi.org/10.1158/2767-9764.22545279
https://doi.org/10.1158/2767-9764.22545279
Autor:
Omar Kabbarah, Karl Hsu, Christopher Szeto, Lishan Kang, Bing Wan, David Bellovin, Qiuping Ye, John Zhang, Yuping Chen, Tom Huang, Zhen Luo, Bee-Chun Sun, Lina Wang, Wenying Li, Min Chen, Grace Wang, Shou Li, Xinchuan Dai, Renyi Wu, Tracey Lin, Hiroyasu Konno
Supplementary Figure 3 shows CLDN18.2 expression in gastric tumor cell lines and ZL-1211-induced CDC for the gastric tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ece513e5fc0cdda7cbc6e0c61ed145
https://doi.org/10.1158/2767-9764.22545576
https://doi.org/10.1158/2767-9764.22545576
Autor:
Omar Kabbarah, Karl Hsu, Christopher Szeto, Lishan Kang, Bing Wan, David Bellovin, Qiuping Ye, John Zhang, Yuping Chen, Tom Huang, Zhen Luo, Bee-Chun Sun, Lina Wang, Wenying Li, Min Chen, Grace Wang, Shou Li, Xinchuan Dai, Renyi Wu, Tracey Lin, Hiroyasu Konno
CLDN18.2 (Claudin18.2)-targeting therapeutic antibodies have shown promising clinical efficacy in approximately 30% of gastric cancers expressing high levels of CLDN18.2 and less pronounced activity in low expressing malignancies. Here, we report tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23593d81e787887277aaaf7ae7488821
https://doi.org/10.1158/2767-9764.c.6550980
https://doi.org/10.1158/2767-9764.c.6550980
Autor:
Benjamin G. Vincent, Heinz-Josef Lenz, Alan P. Venook, Charles David Blanke, Omar Kabbarah, Monica M. Bertagnolli, Scott Van Buren, Fang-Shu Ou, Xueping Qu, Naim Rashid, Akram Yazdani, Federico Innocenti
Supplementary Data from Tumor Immunogenomic Features Determine Outcomes in Patients with Metastatic Colorectal Cancer Treated with Standard-of-Care Combinations of Bevacizumab and Cetuximab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14baf355a476d7d073f29dbc5976f9f5
https://doi.org/10.1158/1078-0432.22487030
https://doi.org/10.1158/1078-0432.22487030
Autor:
Omar Kabbarah, Felipe de Sousa e Melo, Mark R. Lackner, Frederic de Sauvage, Teiko Sumiyoshi, Hartmut Koeppen, Xueping Qu, Elicia Penuel, Jeremy Burton, Rajesh Patel, Rachel Tam, Noelyn Kljavin, Doris Kim, Zora Modrusan, Christiaan Kljin, Ismail Sergin, Ling Huw, Robert Piskol
Purpose:Four consensus molecular subtypes (CMS1–4) of colorectal cancer were identified in primary tumors and found to be associated with distinctive biological features and clinical outcomes. Given that distant metastasis largely accounts for colo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1005ee9c6d84a55771ffa56e48df8e65
https://doi.org/10.1158/1078-0432.c.6527750
https://doi.org/10.1158/1078-0432.c.6527750