Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Omar, Davulcu"'
Autor:
Nancy Meyer, Omar Davulcu, Qing Xie, Mark Silveria, Grant Zane, Edward Large, Michael Chapman
Publikováno v:
Bio-Protocol, Vol 10, Iss 3 (2020)
Adeno-associated virus (AAV) is a promising gene therapy vector and the biophysical characterization of its interactions with host proteins is a critical foundation for engineering tissue targeting and immune escape. Presented here are protocols for
Externí odkaz:
https://doaj.org/article/fa85017bc1074ce58502c5f8dc9123df
Autor:
Qing Xie, John M. Spear, Alex J. Noble, Duncan R. Sousa, Nancy L. Meyer, Omar Davulcu, Fuming Zhang, Robert J. Linhardt, Scott M. Stagg, Michael S. Chapman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 1-12 (2017)
Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously de
Externí odkaz:
https://doaj.org/article/fb211d03182c45d4b321803376200cb3
Autor:
Nancy L Meyer, Guiqing Hu, Omar Davulcu, Qing Xie, Alex J Noble, Craig Yoshioka, Drew S Gingerich, Andrew Trzynka, Larry David, Scott M Stagg, Michael Stewart Chapman
Publikováno v:
eLife, Vol 8 (2019)
Adeno-associated virus (AAV) vectors are preeminent in emerging clinical gene therapies. Generalizing beyond the most tractable genetic diseases will require modulation of cell specificity and immune neutralization. Interactions of AAV with its cellu
Externí odkaz:
https://doaj.org/article/33f133b0391b4a4683dffbce4db37b2b
Autor:
Kenneth C Childers, Nathan G Avery, Kevin Alexander Estrada Alamo, Omar Davulcu, Rose Marie Haynes, Pete Lollar, Christopher B. Doering, Carmen Helena Coxon, Paul Clinton Spiegel
Publikováno v:
Blood Journal.
The development of pathogenic antibody inhibitors against coagulation factor VIII (FVIII) occurs in approximately 30% of congenital hemophilia A patients receiving FVIII replacement therapy as well as in all cases of acquired hemophilia A. KM33 is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c74eec85999136f53081750ccd91799
https://doi.org/10.1182/blood.2023020181
https://doi.org/10.1182/blood.2023020181
Publikováno v:
Chemical Reviews. 122:14018-14054
Adeno-associated virus (AAV) has a single-stranded DNA genome encapsidated in a small icosahedrally symmetric protein shell with 60 subunits. AAV is the leading delivery vector in emerging gene therapy treatments for inherited disorders, so its struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c310a584bb6ae2c1ba405c5ef3ce414d
https://doi.org/10.1021/acs.chemrev.1c00936
https://doi.org/10.1021/acs.chemrev.1c00936
Autor:
Soumya Joseph, Nicholas J. Schnicker, Zhen Xu, Tiandi Yang, Jesse Hopkins, Maxwell Watkins, Srinivas Chakravarthy, Omar Davulcu, Mary E. Anderson, David Venzke, Kevin P. Campbell
Matriglycan is a linear polysaccharide of alternating xylose and glucuronate that binds extracellular matrix proteins and acts as a receptor for Lassa fever virus. LARGE1 synthesizes matriglycan on dystroglycan and mutations in LARGE1 cause muscular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b968ce91005ac4f49f7866b1684992f
https://doi.org/10.1101/2022.05.12.491222
https://doi.org/10.1101/2022.05.12.491222
Autor:
Soumya Joseph, Nicholas J. Schnicker, Zhen Xu, Tiandi Yang, Jesse Hopkins, Maxwell Watkins, Srinivas Chakravarthy, Omar Davulcu, Mary E. Anderson, David Venzke, Kevin P. Campbell
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02ee470cd882347d1f9616d726a88a8e
https://doi.org/10.2139/ssrn.4151031
https://doi.org/10.2139/ssrn.4151031
Autor:
Qing Xie, Michael Chapman, Omar Davulcu, Grant M. Zane, Edward E. Large, Mark A. Silveria, Nancy L. Meyer
Publikováno v:
Bio Protoc
Adeno-associated virus (AAV) is a promising gene therapy vector and the biophysical characterization of its interactions with host proteins is a critical foundation for engineering tissue targeting and immune escape. Presented here are protocols for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c669599e322b111399e47061e1d3c9f1
https://doi.org/10.21769/bioprotoc.3513
https://doi.org/10.21769/bioprotoc.3513
Autor:
Scott M. Stagg, Qing Xie, Alex J. Noble, Duncan Sousa, Fuming Zhang, Omar Davulcu, Nancy L. Meyer, Michael Chapman, Robert J. Linhardt, John M. Spear
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 1-12 (2017)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4aba27a9490dfcd5843ef6d59054ca3
Autor:
Yu Peng, Michael Chapman, Omar Davulcu, Lei Bruschweiler-Li, Alexandar L. Hansen, Jack J. Skalicky, Rafael Brüschweiler
Publikováno v:
Journal of the American Chemical Society. 139:4846-4853
Arginine kinase (AK), which is a member of the phosphagen kinase family, serves as a model system for studying the structural and dynamic determinants of biomolecular enzyme catalysis of all major states involved of the enzymatic cycle. These states
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4d32a0e6c56c065a6ed8588991b077
https://doi.org/10.1021/jacs.7b00236
https://doi.org/10.1021/jacs.7b00236