Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Omar, Akil"'
Autor:
Megumi Hirose-Ikeda, Brian Chu, Paul Zhao, Omar Akil, Elida Escalante, Laurent Vergnes, Carlos Cepeda, Araceli Espinosa-Jeffrey
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 3, Pp 557-568 (2020)
The consequences of neonatal white matter injury are devastating and represent a major societal problem as currently there is no cure. Prematurity, low weight birth and maternal pre-natal infection are the most frequent causes of acquired myelin defi
Externí odkaz:
https://doaj.org/article/d9ce7db71fd0483c978d8f86d95d6026
Publikováno v:
Bio-Protocol, Vol 6, Iss 6 (2016)
The auditory brainstem response (ABR) test provides information about the inner ear (cochlea) and the central pathways for hearing. The ABR reflects the electrical responses of both the cochlear ganglion neurons and the nuclei of the central auditory
Externí odkaz:
https://doaj.org/article/0ba02c0a2f4c4933bb422bce8eba91f0
Autor:
Brian Chu, Araceli Espinosa-Jeffrey, Megumi Hirose-Ikeda, Laurent Vergnes, Elida Escalante, Omar Akil, Carlos Cepeda, Paul M. Zhao
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 3, Pp 557-568 (2020)
Neural Regeneration Research
Neural Regeneration Research
The consequences of neonatal white matter injury are devastating and represent a major societal problem as currently there is no cure. Prematurity, low weight birth and maternal pre-natal infection are the most frequent causes of acquired myelin defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c4abf930d1341a71d3fad884c188e8
http://www.nrronline.org/article.asp?issn=1673-5374
http://www.nrronline.org/article.asp?issn=1673-5374
Autor:
Omar Akil
Publikováno v:
Otolaryngology Open Access Journal. 7
Alpha synuclein (α-Syn) is a small synaptic protein expressed within the central nervous system (CNS). α-Syn has been implicated in the pathogenesis of Parkinson’s disease (PD), and current theory suggests that α-Syn over-expression may lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::863e1ff10cb78c1edacfa1e79a92e5d2
https://doi.org/10.23880/ooaj-16000228
https://doi.org/10.23880/ooaj-16000228
Autor:
Lei Xu, Omar Akil, William W. Hauswirth, Seth Blackshaw, Clayton Santiago, Frank M. Dyka, John D. Ash, Susan Bolch, Kirill A. Martemyanov, James T. Handa, Astra Dinculescu, W. Clay Smith, Ekaterina S. Lobanova, Yuchen Wang
Publikováno v:
The Journal of Pathology
Usher syndrome type 3 (USH3) is an autosomal recessively inherited disorder caused by mutations in the gene clarin‐1 (CLRN1), leading to combined progressive hearing loss and retinal degeneration. The cellular distribution of CLRN1 in the retina re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7eaf5732e656afd4ef0c9337185882
http://europepmc.org/articles/PMC7003947
http://europepmc.org/articles/PMC7003947
Autor:
Omar Akil, Saaid Safieddine, Jacques Boutet de Monvel, Charlotte Calvet, Frank M. Dyka, Ghizlene Lahlou, Sylvie Nouaille, Jean-Pierre Hardelin, Paul Avan, Alice Emptoz, Christine Petit, William W. Hauswirth, Lawrence R. Lustig
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (10), pp.4496-4501. ⟨10.1073/pnas.1817537116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (10), pp.4496-4501. ⟨10.1073/pnas.1817537116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (10), pp.4496-4501. ⟨10.1073/pnas.1817537116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (10), pp.4496-4501. ⟨10.1073/pnas.1817537116⟩
Significance In humans, inner ear development is completed in utero, with hearing onset at ∼20 weeks of gestation. However, genetic forms of congenital deafness are typically diagnosed during the neonatal period. Gene therapy approaches in animal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a59eb91d9ac9543df3524f03209acd9
https://doi.org/10.1073/pnas.1817537116
https://doi.org/10.1073/pnas.1817537116
Autor:
Omar Akil, Faith Hall-Glenn, Jolie Chang, Alfred Li, Wenhan Chang, Lawrence R Lustig, Tamara Alliston, Edward C Hsiao
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e94989 (2014)
Normal hearing requires exquisite cooperation between bony and sensorineural structures within the cochlea. For example, the inner ear secretes proteins such as osteoprotegrin (OPG) that can prevent cochlear bone remodeling. Accordingly, diseases tha
Externí odkaz:
https://doaj.org/article/0cbb2860754e4465b8857aa1062b1f5c
Autor:
Omar Akil, Lawrence Lustig
Publikováno v:
Bio-Protocol, Vol 3, Iss 5 (2013)
This protocol comprises the entire process of immunofluorescence staining on mouse cochlea whole mount, starting from tissue preparation to the mounting of the tissue. This technique provides “three-dimensional” views of the stained components in
Externí odkaz:
https://doaj.org/article/c1f4da39b5a94642bace0dee1139f909
Autor:
Stephanie L Rouse, Conor W. McLaughlin, Jiang Li, Omar Akil, Elliott H. Sherr, Ian R. Matthews, Lawrence R. Lustig, Dylan K. Chan
Publikováno v:
The Journal of clinical investigation, vol 128, iss 11
Hearing loss is a significant public health concern, affecting over 250 million people worldwide. Both genetic and environmental etiologies are linked to hearing loss, but in many cases the underlying cellular pathophysiology is not well understood,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73111e4f543aa7814ff0c1a3283fc1b1
https://doi.org/10.1172/jci97498
https://doi.org/10.1172/jci97498
Autor:
Omar Akil
Publikováno v:
Hearing research. 394
Adeno-associated virus (AAV)-mediated gene therapy has evolved from the bench to the bedside, and is now considered the therapy of choice for certain inherited diseases. AAVs are attractive vectors for several reasons: they are nonpathogenic, result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba8f7f2844d433f973781ee02fc750a
https://pubmed.ncbi.nlm.nih.gov/32067799
https://pubmed.ncbi.nlm.nih.gov/32067799