Complete inhibition of liver acetyl-CoA carboxylase activity is required to exacerbate liver tumorigenesis in mice treated with diethylnitrosamine.

Autor: Shrestha R; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Vancuylenburg CS; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Beretta M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Zhou M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Shah DP; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Olzomer EM; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Richards SL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Byrne FL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia. Frances.byrne@unsw.edu.au.

Publikováno v: Cancer & metabolism [Cancer Metab] 2024 Nov 13; Vol. 12 (1), pp. 34. Date of Electronic Publication: 2024 Nov 13.

Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents.

Autor: Cheng Y; School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia., Jones JP; School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia., Yu TT; School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia., Olzomer EM; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Su J; School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia., Katen A; School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia., Black DS; School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia., Hart-Smith G; Australian Proteome Analysis Facility, Macquarie University, Macquarie Park, NSW 2109, Australia., Childress ES; Department of Chemistry and VT Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA., Wilkins MR; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Mateos IA; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Santos WL; Department of Chemistry and VT Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA., Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Byrne FL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: frances.byrne@unsw.edu.au., Kumar N; School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: n.kumar@unsw.edu.au.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Oct; Vol. 151, pp. 107665. Date of Electronic Publication: 2024 Jul 25.

The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues.

Autor: Coates HW; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales, Australia., Nguyen TB; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales, Australia., Du X; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales, Australia., Olzomer EM; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales, Australia., Farrell R; Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia; Prince of Wales Private Hospital, Randwick, New South Wales, Australia., Byrne FL; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales, Australia., Yang H; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales, Australia., Brown AJ; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales, Australia. Electronic address: aj.brown@unsw.edu.au.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 May; Vol. 300 (5), pp. 107232. Date of Electronic Publication: 2024 Mar 26.

Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice.

Autor: Beretta M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Dai Y; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA., Olzomer EM; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Vancuylenburg CS; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Santiago-Rivera JA; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA., Philp AM; St Vincent's Clinical School, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia., Hargett SR; Department of Pharmacology, University of Virginia, Charlottesville, VA., Li K; Department of Pharmacology, University of Virginia, Charlottesville, VA., Shah DP; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Chen SY; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Alexopoulos SJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Li C; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Harris TE; Department of Pharmacology, University of Virginia, Charlottesville, VA., Lee B; Biological Resources Imaging Laboratory, University of New South Wales, Sydney, New South Wales, Australia., Wathier M; Life Biosciences, Boston, MA., Cermak JM; Life Biosciences, Boston, MA., Tucker SP; Life Biosciences, Boston, MA.; Firebrick Pharma, Melbourne, Victoria, Australia., Turner N; Cellular Bioenergetics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia., Bayliss DA; Department of Pharmacology, University of Virginia, Charlottesville, VA., Philp A; Centre for Healthy Ageing, Centenary Institute, Camperdown, New South Wales, Australia.; School of Sport, Exercise and Rehabilitation Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia., Byrne FL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Santos WL; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA., Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia.; Department of Pharmacology, University of Virginia, Charlottesville, VA.

Publikováno v: Diabetes [Diabetes] 2024 Mar 01; Vol. 73 (3), pp. 374-384.

Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice.

Autor: Chen SY; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Beretta M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Olzomer EM; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Alexopoulos SJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Shah DP; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Byrne FL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Salamoun JM; Department of Chemistry and Virginia Tech Centre for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA., Garcia CJ; Department of Chemistry and Virginia Tech Centre for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA., Smith GC; School of Medical Science, University of New South Wales, Sydney, NSW 2052, Australia., Larance M; Charles Perkins Centre, School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia., Philp A; Charles Perkins Centre, School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia; Centre for Healthy Ageing, Centenary Institute, Camperdown, NSW 2050, Australia; School of Sport, Exercise and Rehabilitation Sciences, Faculty of Health, University of Technology Sydney, Sydney, NSW 2007, Australia., Turner N; Cellular Bioenergetics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia., Santos WL; Department of Chemistry and Virginia Tech Centre for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA., Cantley J; School of Medicine, University of Dundee, Dundee DD1 4HN, UK., Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: k.hoehn@unsw.edu.au.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Jan; Vol. 1870 (1), pp. 166908. Date of Electronic Publication: 2023 Oct 02.