Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Olympe Depelchin"'
Autor:
Sophie Kervyn, Guy-Marie Dubin, Hugues Chanteux, Olympe Depelchin, Brigitte Gerin, Ludovicus Staelens, Valérie Mancel, Jean-Marie Nicolas
Publikováno v:
Toxicological Sciences. 141:353-364
A new antiepileptic synaptic vesicle 2a (SV2a) ligand drug candidate was tested in 4-week oral toxicity studies in rat and dog. Brown pigment inclusions were found in the liver of high-dose dogs. The morphology of the deposits and the accompanying li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e320eea2cf19421ff91f05bec90aa5
https://doi.org/10.1093/toxsci/kfu131
https://doi.org/10.1093/toxsci/kfu131
Autor:
Stephane Dhalluin, Franck A. Atienzar, Etienne Hanon, Olympe Depelchin, Helga Gerets, Miranda Cornet, Michael Canning
Publikováno v:
Toxicology in Vitro. 23:319-332
The present study was undertaken to validate a battery of cytotoxicity assays performed in a multiplex format to screen pharmaceutical compounds at an early stage of drug development. Two experiments were performed on HepG2 cells and the parameters w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af4add5acf395eb9aa9d35500815c6c
https://doi.org/10.1016/j.tiv.2008.11.012
https://doi.org/10.1016/j.tiv.2008.11.012
Autor:
Becky Schweighardt, Inge A. Ivens, Theodora Salcedo, Peter Turecek, B. Olympe Depelchin, Birgit M. Reipert, Jennifer Sims, Joan Lane, Maggie Dempster, Joy A. Cavagnaro, Andreas Baumann, William E. Achanzar, Laura Dill-Morton, Annamaria Brändli-Baiocco, Armando R. Irizarry Rovira, Laurie S. Tsuruda
Publikováno v:
Toxicologic pathology. 43(7)
PEGylation (the covalent binding of one or more polyethylene glycol molecules to another molecule) is a technology frequently used to improve the half-life and other pharmaceutical or pharmacological properties of proteins, peptides, and aptamers. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689cd28ca9c4993e17662037dbc0a48c
https://pubmed.ncbi.nlm.nih.gov/26239651
https://pubmed.ncbi.nlm.nih.gov/26239651
Autor:
Yvon Rabemampianina, Lieve Lammens, Markus Stephan-Gueldner, Friedrich von Landenberg, Claudia Stark, Olympe Depelchin, Rudolf Pfister, David M. Smith, Robert Combes, Ruediger Hack, Joerg Luft, Barry Phillips, Soren Dyring Jacobsen, Susan Sparrow
Publikováno v:
Regulatory Toxicology and Pharmacology. 41:95-101
A working party, comprising two animal welfare organisations and some 12 pharmaceutical companies in Europe, was established to minimise the use of the dog in safety testing. As first step, the participants defined the major objectives of preliminary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddeeee3a8ebf7ffebe09170b4c03e50
https://doi.org/10.1016/j.yrtph.2004.10.006
https://doi.org/10.1016/j.yrtph.2004.10.006
Autor:
Annie Delaunois, Etienne Hanon, Pierrette De Ron, Michel Guyaux, Eric Jnoff, Miranda Cornet, Marie-Luce Rosseels, Brigitte Olympe Depelchin, Paul Dedoncker
Publikováno v:
Fundamentalclinical pharmacology. 28(4)
A selective α2C -adrenoceptor (AR) agonist was developed for the treatment of neuropathic pain. The objective was to dissociate analgesic activity from cardiovascular and sedative side effects commonly observed with nonselective agents. A 2-amino-ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fa53d0e2f1c67c2a4bfc887db2311d
https://pubmed.ncbi.nlm.nih.gov/24020399
https://pubmed.ncbi.nlm.nih.gov/24020399
Autor:
Mario Sgro, Jean-Pierre Valentin, Frederic Martin, Olympe Depelchin, Mary Jeanne Kallman, Christopher Peters, François-Xavier Mathy, Marie-Luce Rosseels
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 75:163
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ea3a8e2bacc044d36c3f1fa6915d706
https://doi.org/10.1016/j.vascn.2015.08.019
https://doi.org/10.1016/j.vascn.2015.08.019