Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Oluyomi M. Okunola"'
Autor:
Ashwini K. Banala, Martin H. Moore, Rana Rais, Barbara S. Slusher, Rachel D. Slack, Amy Hauck Newman, Caitlin Burzynski, Jeffrey R. Deschamps, Oluyomi M. Okunola-Bakare, Thomas M. Keck, Alessandro Bonifazi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4000-4012
The dopamine D3 receptor (D3R) is a target of pharmacotherapeutic interest in a variety of neurological disorders including schizophrenia, Parkinson's disease, restless leg syndrome, and drug addiction. A common molecular template used in the develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81a04d310bf91ce40921b649007718c
https://doi.org/10.1016/j.bmc.2015.01.017
https://doi.org/10.1016/j.bmc.2015.01.017
Autor:
Zheng-Xiong Xi, Yi He, Eliot L. Gardner, Xiao-Fei Wang, Oluyomi M. Okunola-Bakare, Hong-Ju Yang, Rachel D. Slack, Jun-Tao Gao, Guo-Hua Bi, Amy Hauck Newman
Publikováno v:
Neuropsychopharmacology. 40:1762-1771
(±)-Modafinil (MOD) is used clinically for the treatment of sleep disorders and has been investigated as a potential medication for the treatment of psychostimulant addiction. However, the therapeutic efficacy of (±)-MOD for addiction is inconclusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f15f429c0221258ce44f9de12ce61c
https://doi.org/10.1038/npp.2015.24
https://doi.org/10.1038/npp.2015.24
Autor:
Jonathan L. Katz, Claus J. Loland, Lei Shi, Theresa A. Kopajtic, Jianjing Cao, Amy Hauck Newman, Oluyomi M. Okunola-Bakare
Publikováno v:
Journal of Medicinal Chemistry
2-[(Diphenylmethyl)sulfinyl]acetamide (modafinil, (±)-1) is a unique dopamine uptake inhibitor that binds the dopamine transporter (DAT) differently than cocaine and may have potential for the treatment of psychostimulant abuse. To further investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81e5daf4486c566c5eb0722d8472845
https://doi.org/10.1021/jm401754x
https://doi.org/10.1021/jm401754x
Autor:
Jonathan L. Katz, Jianjing Cao, Oluyomi M. Okunola, Thomas E. Prisinzano, Matthew Shook, Theresa A. Kopajtic, Amy Hauck Newman
Publikováno v:
ACS Medicinal Chemistry Letters. 2:48-52
A series of modafinil (1) analogues were synthesized wherein (1) para-halo-substitutents were added to the aryl rings, (2) the sulfoxide function was removed, and (3) the primary amide group was replaced with secondary and tertiary amides and amines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::583ca7babbfaeae77538cf3a7d87bbbf
https://doi.org/10.1021/ml1002025
https://doi.org/10.1021/ml1002025
Autor:
Amy Hauck Newman, Jianjing Cao, Gianluigi Tanda, Sonia Mazier, Claus J. Loland, Thomas E. Prisinzano, Lei Shi, Jonathan L. Katz, Theresa A. Kopajtic, Maddalena Mereu, Oluyomi M. Okunola
Background (±)-Modafinil has piqued interest as a treatment for attention-deficit/hyperactivity disorder and stimulant dependence. The R-enantiomer of modafinil might have unique pharmacological properties that should be further investigated. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3137904f87ae84e17a213992efdfb99
https://europepmc.org/articles/PMC3413742/
https://europepmc.org/articles/PMC3413742/
Autor:
Jianjing, Cao, Thomas E, Prisinzano, Oluyomi M, Okunola, Theresa, Kopajtic, Matthew, Shook, Jonathan L, Katz, Amy Hauck, Newman
Publikováno v:
ACS medicinal chemistry letters. 2(1)
A series of modafinil (1) analogues was synthesized wherein 1) para-halo-substitutents were added to the aryl rings, 2) the sulfoxide function was removed, and 3) the primary amide group was replaced with secondary and tertiary amides and amines to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6eea29ea043588c0566966f6697c27c1
https://pubmed.ncbi.nlm.nih.gov/21344069
https://pubmed.ncbi.nlm.nih.gov/21344069