Výsledky vyhledávání - "Oluwole B. Akawa"

Akademický článek

Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats

Autor: Scholastica O. Anadozie, Olusola B. Adewale, Oluwole B. Akawa, Juliet N. Olayinka, Olukemi A. Osukoya, Margaret M. Umanah, Oyindamola A. Olaoye, Oluwatosin S. Oludoro

Publikováno v: Journal of HerbMed Pharmacology, Vol 12, Iss 1, Pp 159-167 (2023)

Introduction: Mondia whitei (Hook.f.) Skeels is rich in antioxidant activity and is known for its nutritional and medicinal uses. This study evaluated the protective effect of M. whitei fruit against cadmium-induced hepatic damage in rats. Methods: T

Externí odkaz: https://doaj.org/article/f2194e299e61473c9dcf6099e555112f

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Akademický článek

Hibiscus sabdariffa synthesized gold nanoparticles ameliorate aluminum chloride induced memory deficits through inhibition of COX-2/BACE-1 mRNA expression in rats

Autor: Scholastica O. Anadozie, Duncan O. Effiom, Olusola B. Adewale, Jodie Jude, Itumeleng Zosela, Oluwole B. Akawa, Juliet N. Olayinka, Saartjie Roux

Publikováno v: Arabian Journal of Chemistry, Vol 16, Iss 4, Pp 104604- (2023)

Alzheimer’s disease (AD) is a major health challenge worldwide, especially among the elderly. The disease is associated with cognitive and memory deficits. This study investigated the effect of Hibiscus sabdariffa synthesized-gold nanoparticles (HS

Externí odkaz: https://doaj.org/article/857876a0a38d4976b7896bc34a26bb63

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Akademický článek

Apigenin attenuates depressive-like behavior via modulating monoamine oxidase A enzyme activity in chronically stressed mice

Autor: Juliet N. Olayinka, Oluwole B. Akawa, Emmanuela K. Ogbu, Anthony T. Eduviere, Raymond I. Ozolua, Mahmoud Soliman

Publikováno v: Current Research in Pharmacology and Drug Discovery, Vol 5, Iss , Pp 100161- (2023)

Chronic stress is a risk factor for depression and is characterized by elevated levels of brain monoamine oxidase A (MAOA). Mounting evidence has shown that MAOA is a biochemical link between stress and depression. Apigenin (API), a natural flavonoid

Externí odkaz: https://doaj.org/article/7b0e17ff8d9a47f1ad4cd1a916263ca3

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Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats

Autor: Scholastica O. Anadozie, Olusola B. Adewale, Oluwole B. Akawa, Juliet N. Olayinka, Olukemi A. Osukoya, Margaret M. Umanah, Oyindamola A. Olaoye, Oluwatosin S. Oludoro

Publikováno v: Journal of Herbmed Pharmacology. 12:159-167

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a5082c2559f08c7d98040ac6d1414bb
https://doi.org/10.34172/jhp.2023.16

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Piecing the Fragments Together: Dynamical Insights into the Enhancement of BRD4-BD1 (BET Protein) Druggability in Cancer Chemotherapy Using Novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives

Autor: Mahmoud E. S. Soliman, Fisayo A. Olotu, Oluwole B. Akawa, Opeyemi S. Soremekun

Publikováno v: Current Pharmaceutical Biotechnology. 23:444-456

Background: Fragment-based drug discovery in recent times has been explored in the design of highly potent therapeutics. Methods: In this study, we explored the inhibitory dynamics of Compound 38 (Cpd38), a newly synthesized Bromodomain-containing pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ea2d0c108a8b94e1e51cdd2c9f7cc5
https://doi.org/10.2174/1389201022666210322122056

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Could the spanning of NAM-AD subsites by poly (ADP ribose) polymerase inhibitors potentiate their selective inhibitory activity in breast cancer treatment? Insight from biophysical computations

Autor: Oluwole B. Akawa, Mahmoud E. S. Soliman, Felix O. Okunlola

Publikováno v: Molecular Simulation. 48:131-139

Poly (ADP-ribose) polymerase (PARP) inhibition by pharmacological agents has been a useful cancer treatment in recent times. PARP inhibitors represent a category of anticancer drugs that function b...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24388c094eb587541ebb06a87a39b362
https://doi.org/10.1080/08927022.2021.1994562

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Unravelling the Mechanistic Role of Quinazolinone Pharmacophore in the Inhibitory Activity of Bis-quinazolinone Derivative on Tankyrase-1 in the Treatment of Colorectal Cancer (CRC) and Non-small Cell Lung Cancer (NSCLC): A Computational Approach

Autor: Oluwole B. Akawa, Felix O. Okunlola, Mahmoud E. S. Soliman, Temitayo I. Subair, Kehinde F. Omolabi

Publikováno v: Cell Biochemistry and Biophysics. 80:1-10

In recent years, tankyrase inhibition has gained a great focus as an anti-cancer strategy due to their modulatory effect on WNT/β-catenin pathway implicated in many malignancies, including colorectal cancer (CRC) and non-small cell lung cancer (NSCL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54bfced386f7cfc9ac7dd16b5a4a1b7b
https://doi.org/10.1007/s12013-021-01027-3

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Structural alterations in the catalytic core of hSIRT2 enzyme predict therapeutic benefits of Garcinia mangostana derivatives in Alzheimer's disease: molecular dynamics simulation study

Autor: Temitayo I. Subair, Opeyemi S. Soremekun, Mahmoud E. S. Soliman, Oluwole B. Akawa, Fisayo A. Olotu

Publikováno v: RSC Advances. 11:8003-8018

Recent studies have shown that inhibition of the hSIRT2 enzyme provides favorable effects in neurodegenerative diseases such as Alzheimer's disease. Prenylated xanthone phytochemicals including α-mangostin, β-mangostin and γ-mangostin obtained fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53821f2faab8873431122bfbb0b85f37
https://doi.org/10.1039/d0ra10459k

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