Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Olutayo Ogun"'
Publikováno v:
Proceedings of the National Academy of Sciences. 107:13282-13287
We have experimentally determined the coexistence surface characterizing the phase behavior of gammaD-betaB1-water ternary solutions. The coexistence surface fully describes the solution conditions, i.e., temperature, protein concentration, and prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df622960844a46c05c70b2b95c8d656
https://doi.org/10.1073/pnas.1008353107
https://doi.org/10.1073/pnas.1008353107
Autor:
Jennifer J. McManus, Jayanti Pande, Aleksey Lomakin, George B. Benedek, Markus Basan, Ajay Pande, Olutayo Ogun
Publikováno v:
Proceedings of the National Academy of Sciences. 104:16856-16861
The P23T mutant of human γD-crystallin (HGD) is associated with cataract. We have previously investigated the solution properties of this mutant, as well as those of the closely related P23V and P23S mutants, and shown that although mutations at sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39172a23c3c7e097dcfe9480c42fe434
https://doi.org/10.1073/pnas.0707412104
https://doi.org/10.1073/pnas.0707412104
Publikováno v:
Biochemistry. 44:2491-2500
The P23T mutation in the human gammaD-crystallin gene has in recent years been associated with a number of well known cataract phenotypes. To understand the molecular mechanism of lens opacity caused by this mutation, we expressed human gammaD-crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230e51b3356211d3a3ae8c20d5d77422
https://doi.org/10.1021/bi0479611
https://doi.org/10.1021/bi0479611
Autor:
Ying Wang, Nikhil C. Munshi, Kenneth C. Anderson, Aleksey Lomakin, Teru Hideshima, Paul G. Richardson, Olutayo Ogun, George B. Benedek, Jacob P. Laubach
Publikováno v:
Proceedings of the National Academy of Sciences. 109:13359-13361
Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49aaefa652b84b882d3ebcec7a56137d
https://doi.org/10.1073/pnas.1211723109
https://doi.org/10.1073/pnas.1211723109
Autor:
Jayanti Pande, Ajay Pande, Neer Asherie, Aleksey Lomakin, George B. Benedek, Jennifer A. Zarutskie, Lawrence J. Stern, Joseph Lomakin, Olutayo Ogun, Jonathan King
Publikováno v:
Journal of Molecular Biology. 314:663-669
The cysteine residues of the γ crystallins, a family of ocular lens proteins, are involved in the aggregation and phase separation of these proteins. Both these phenomena are implicated in cataract formation. We have used bovine γB crystallin as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228be4b6831e4d597e48d7e1544fb1c4
https://doi.org/10.1006/jmbi.2001.5155
https://doi.org/10.1006/jmbi.2001.5155
Autor:
Stacy R.A. Hanson, Neer Asherie, Olutayo Ogun, George B. Benedek, Jayanti Pande, Jean B. Smith, Aleksey Lomakin
Publikováno v:
Biophysical Chemistry. 75:213-227
We have chemically crosslinked a globular protein, gamma IIIb-crystallin, to produce a system of well-defined oligomers: monomers, dimers, trimers and a mixture of higher n-mers. Gel electrophoresis, size exclusion chromatography, quasielastic light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1f1242f1f4a5421981dd65a2e1b078
https://doi.org/10.1016/s0301-4622(98)00208-7
https://doi.org/10.1016/s0301-4622(98)00208-7
Publikováno v:
Current Eye Research. 15:1182-1190
Solutions of the bovine lens protein gamma B (or gamma II) crystallin at neutral pH in the absence of reducing agents, undergo a slow, partial conversion to a new protein species, gamma IIH. This species is an aggregate composed of an intermolecular,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d865dd4a5cb9a772fb3a21580caf8c
https://doi.org/10.3109/02713689608995154
https://doi.org/10.3109/02713689608995154
Publikováno v:
The Journal of Chemical Physics. 104:326-335
We report our measurement of the time average and the temporal autocorrelation function of the intensity of light scattered by the highly monomeric globular protein, bovine γII‐crystallin, in aqueous solution as a function of wave number q, protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1074495b34f81aac4569c137ada18220
https://doi.org/10.1063/1.470904
https://doi.org/10.1063/1.470904
Autor:
Bernard M. Fine, I. Sokolinski, Aleksey Lomakin, Jayanti Pande, Olutayo Ogun, George B. Benedek
Publikováno v:
Proceedings of the National Academy of Sciences. 92:1067-1071
Aqueous solutions of the bovine eye lens protein gamma II (or gamma B)-crystallin at neutral pH show a gradual increase in phase separation temperature, Tph, when allowed to stand for several weeks at room temperature without reducing agents. In a ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75dd67e26fddf9190193c6498d4cf2f
https://doi.org/10.1073/pnas.92.4.1067
https://doi.org/10.1073/pnas.92.4.1067
Publikováno v:
Physical Review Letters. 74:198-201
An aqueous protein solution is a binary mixture of large particles (protein molecules) and small particles (water molecules). In contrast, a binary liquid mixture is a mixture of two different kinds of particles that are approximately the same size.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a0851e88581d818613085f6e885f45
https://doi.org/10.1103/physrevlett.74.198
https://doi.org/10.1103/physrevlett.74.198