Evaluating the implementation outcome 'acceptability' of the Eight (8) Antenatal Care contacts, and modelling the predictors that determine compliance by women attending Antenatal care clinics in Wakiso district

Autor: Innocent Ssemanda, Kalembe Brenda, Riri Johnson Vonje, Karen Mwengwe, Okwadi Tukei, Oluseye A Ogunbayo

BackgroundThe World Health Organization increased the number of antenatal care (ANC) visits from Four (4) to Eight (8) visits or more, to reduce the exponentiated incidences of preventable deaths of newborns, maternal mortality, perinatal, and stillb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5690fb45e9a122ea98b66187b8a4e4a9
https://doi.org/10.1101/2023.01.06.23284275

The hypoxic ventilatory response is facilitated by the activation of Lkb1-AMPK signalling pathways downstream of the carotid bodies

Autor: C. N. Wyatt, Oluseye A. Ogunbayo, Sandy MacMillan, Benoit Viollet, Andrew P. Holmes, A. M. Evans, M. Dallas, Marc Foretz, Prem Kumar, Amira D. Mahmoud

We recently demonstrated that the role of the AMP-activated protein kinase (AMPK), a ubiquitously expressed enzyme that governs cell-autonomous metabolic homeostasis, has been extended to system-level control of breathing and thus oxygen and energy (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89aed5173d23746e9ea63a8980120e70

mTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2

Autor: Jian Xiong, Jianjie Ma, Michael X. Zhu, A. Mark Evans, Oluseye A. Ogunbayo, Xinghua Feng, Jingxian Duan, Qiaochu Wang

Publikováno v: Ogunbayo, O A, Duan, J, Xiong, J, Wang, Q, Feng, X, Ma, J, Zhu, M X & Evans, A M 2018, ' mTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2 ', Science Signaling, vol. 11, no. 525, eaao5775 . https://doi.org/10.1126/scisignal.aao5775

Two-pore segment channel 2 (TPC2) is a ubiquitously expressed, lysosomally targeted ion channel that aids in terminating autophagy and is inhibited upon its association with mechanistic target of rapamycin (mTOR). It is controversial whether TPC2 med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2facb36c5688656936fc73a24468e1
https://doi.org/10.1126/scisignal.aao5775

Exome Sequencing and the Management of Neurometabolic Disorders

Autor: David S. Wishart, Bojana Rakic, Casper Shyr, Rupasri Mandal, Maja Tarailo-Graovac, Andre Mattman, Cristina Skrypnyk, Patrice Eydoux, Paul Shekel, Majid Alfadhel, Stuart E. Turvey, Janis M. Dionne, Hilary Vallance, Michelle Demos, A. Mark Evans, Colin J. D. Ross, Anna Lehman, Matthias R. Baumgartner, Jacob Rozmus, Bryan Sayson, Jan M. Friedman, Margaret L. McKinnon, Andrea Superti-Furga, Leo A. J. Kluijtmans, Britt I. Drögemöller, Kathryn Selby, Mary B. Connolly, Gabriella Horvath, Daniel Metzger, Kirk R. Schultz, John K. Wu, Ian Garber, Linlea Armstrong, Jessie M. Cameron, Ramona Salvarinova, Clara D.M. van Karnebeek, Dimitrios I. Zafeiriou, Jiqiang Ling, Ron A. Wevers, Lin Hua Zhang, Jiang Wu, Oluseye A. Ogunbayo, Graham Sinclair, Sylvia Stockler-Ipsiroglu, Suzanne M E Lewis, Margot I. Van Allen, Jessica J. Y. Lee, Wyeth W. Wasserman, Mena Abdelsayed, Peter C. Ruben, Patricie Burda, Aspasia Michoulas, Sandra Sirrs, Saikat Santra, Xin C. Ye, Tammie Dewan, Amit P. Bhavsar

Publikováno v: The New England Journal of Medicine, 374, 2246-2255
Tarailo-Graovac, M, Shyr, C, Ross, C J, Horvath, G A, Salvarinova, R, Ye, X C, Zhang, L-H, Bhavsar, A P, Lee, J J Y, Drögemöller, B I, Abdelsayed, M, Alfadhel, M, Armstrong, L, Baumgartner, M R, Burda, P, Connolly, M B, Cameron, J, Demos, M, Dewan, T, Dionne, J, Evans, A M, Friedman, J M, Garber, I, Lewis, S, Ling, J, Mandal, R, Mattman, A, McKinnon, M, Michoulas, A, Metzger, D, Ogunbayo, O A, Rakic, B, Rozmus, J, Ruben, P, Sayson, B, Santra, S, Schultz, K R, Selby, K, Skehel, P, Sirrs, S, Skrypnyk, C, Superti-Furga, A, Turvey, S E, Van Allen, M I, Wishart, D, Wu, J, Wu, J, Zafeiriou, D, Kluijtmans, L, Wevers, R A, Eydoux, P, Lehman, A M, Vallance, H, Stockler-Ipsiroglu, S, Sinclair, G, Wasserman, W W & van Karnebeek, C D 2016, ' Exome Sequencing and the Management of Neurometabolic Disorders ', New England Journal of Medicine, vol. 374, no. 23, pp. 2246-2255 . https://doi.org/10.1056/NEJMoa1515792
New England journal of medicine, 374(23), 2246-2255. Massachussetts Medical Society
The New England Journal of Medicine, 374, 23, pp. 2246-2255

BACKGROUND: Whole-exome sequencing has transformed gene discovery and diagnosis in rare diseases. Translation into disease-modifying treatments is challenging, particularly for intellectual developmental disorder. However, the exception is inborn err

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1823805f7dbec3d76416ca8041bb3f3f
https://pubmed.ncbi.nlm.nih.gov/27282444

Endocrine disrupting alkylphenols: Structural requirements for their adverse effects on Ca2+pumps, Ca2+ homeostasis & Sertoli TM4 cell viability

Autor: Fawaz Al-Mousa, Christopher J. Kirk, Pei F. Lai, Francesco Michelangeli, Laura L. Wootton, Oluseye A. Ogunbayo, R.M. Harris, Rosemary H. Waring

Publikováno v: Chemico-Biological Interactions. 176:220-226

Alkylphenols such as nonylphenol are pollutants that are widely dispersed within our environment. They bio-accumulate within man, with levels in the μM concentration range reported in human tissues. These chemicals act as endocrine disruptors, havin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6110f011b81acda34602e1954cf238c9
https://doi.org/10.1016/j.cbi.2008.08.005